Prognosis of resected non-small cell lung cancer with pleural plaques on intrathoracic findings
Abstract Background The prognosis of patients with lung cancer who demonstrate pleural plaques intraoperatively, which may be associated with exposure to asbestos, is unclear. Here, we compared the clinicopathological characteristics and prognosis of these patients to those of patients without pleur...
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| Format: | Article |
| Language: | English |
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BMC
2022-04-01
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| Series: | BMC Cancer |
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| Online Access: | https://doi.org/10.1186/s12885-022-09600-6 |
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| author | Atsushi Kagimoto Takeshi Mimura Atsushi Kamigaichi Yoshinori Yamashita |
| author_facet | Atsushi Kagimoto Takeshi Mimura Atsushi Kamigaichi Yoshinori Yamashita |
| author_sort | Atsushi Kagimoto |
| collection | DOAJ |
| description | Abstract Background The prognosis of patients with lung cancer who demonstrate pleural plaques intraoperatively, which may be associated with exposure to asbestos, is unclear. Here, we compared the clinicopathological characteristics and prognosis of these patients to those of patients without pleural plaques. Methods We included patients who underwent curative-intent resection for non-small cell lung cancer. We retrospectively investigated the relationship of intrathoracic findings of pleural plaques with clinicopathological features and prognosis. Results Pleural plaques were found in 121/701 patients (17.3%) during surgery. The incidence of squamous cell carcinoma (P < 0.001) and the pathological stage (P = 0.021) were higher in patients with pleural plaques. Overall survival was significantly worse in patients with pleural plaques (5-year rate; 64.5% vs. 79.3%; P < 0.001), and the same finding was noted in clinical stage I patients (5-year rate; 64.8% vs. 83.4%; P < 0.001). In multivariable analysis, the presence of pleural plaques was a significant predictor of overall survival in patients with clinical stage I (hazard ratio, 1.643; P = 0.036). In the analysis among patients with emphysema more severe than Goddard score 5 points or interstitial pneumonia, overall survival was significantly worse in those with pleural plaques than in those without pleural plaques (5-year rate; 66.3% vs. 49.5%; P < 0.001). Conclusions Patients with non-small cell lung cancer who underwent resection and demonstrated pleural plaques intraoperatively had a significantly worse prognosis. It is important to recognize the presence of pleural plaques intraoperatively, and our findings will be useful in determining the treatment and follow-up strategy for such patients with lung cancer and pleural plaques on intrathoracic examination. |
| first_indexed | 2024-04-13T23:18:51Z |
| format | Article |
| id | doaj.art-c87026dd8d92435384cb4071d8eecc42 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-04-13T23:18:51Z |
| publishDate | 2022-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-c87026dd8d92435384cb4071d8eecc422022-12-22T02:25:18ZengBMCBMC Cancer1471-24072022-04-0122111110.1186/s12885-022-09600-6Prognosis of resected non-small cell lung cancer with pleural plaques on intrathoracic findingsAtsushi Kagimoto0Takeshi Mimura1Atsushi Kamigaichi2Yoshinori Yamashita3Department of General Thoracic Surgery, National Hospital Organization, Kure Medical Center and Chugoku Cancer CenterDepartment of General Thoracic Surgery, National Hospital Organization, Kure Medical Center and Chugoku Cancer CenterDepartment of General Thoracic Surgery, National Hospital Organization, Kure Medical Center and Chugoku Cancer CenterDepartment of General Thoracic Surgery, National Hospital Organization, Kure Medical Center and Chugoku Cancer CenterAbstract Background The prognosis of patients with lung cancer who demonstrate pleural plaques intraoperatively, which may be associated with exposure to asbestos, is unclear. Here, we compared the clinicopathological characteristics and prognosis of these patients to those of patients without pleural plaques. Methods We included patients who underwent curative-intent resection for non-small cell lung cancer. We retrospectively investigated the relationship of intrathoracic findings of pleural plaques with clinicopathological features and prognosis. Results Pleural plaques were found in 121/701 patients (17.3%) during surgery. The incidence of squamous cell carcinoma (P < 0.001) and the pathological stage (P = 0.021) were higher in patients with pleural plaques. Overall survival was significantly worse in patients with pleural plaques (5-year rate; 64.5% vs. 79.3%; P < 0.001), and the same finding was noted in clinical stage I patients (5-year rate; 64.8% vs. 83.4%; P < 0.001). In multivariable analysis, the presence of pleural plaques was a significant predictor of overall survival in patients with clinical stage I (hazard ratio, 1.643; P = 0.036). In the analysis among patients with emphysema more severe than Goddard score 5 points or interstitial pneumonia, overall survival was significantly worse in those with pleural plaques than in those without pleural plaques (5-year rate; 66.3% vs. 49.5%; P < 0.001). Conclusions Patients with non-small cell lung cancer who underwent resection and demonstrated pleural plaques intraoperatively had a significantly worse prognosis. It is important to recognize the presence of pleural plaques intraoperatively, and our findings will be useful in determining the treatment and follow-up strategy for such patients with lung cancer and pleural plaques on intrathoracic examination.https://doi.org/10.1186/s12885-022-09600-6Pleural plaquesNon-small cell lung cancerAsbestosLung cancer |
| spellingShingle | Atsushi Kagimoto Takeshi Mimura Atsushi Kamigaichi Yoshinori Yamashita Prognosis of resected non-small cell lung cancer with pleural plaques on intrathoracic findings BMC Cancer Pleural plaques Non-small cell lung cancer Asbestos Lung cancer |
| title | Prognosis of resected non-small cell lung cancer with pleural plaques on intrathoracic findings |
| title_full | Prognosis of resected non-small cell lung cancer with pleural plaques on intrathoracic findings |
| title_fullStr | Prognosis of resected non-small cell lung cancer with pleural plaques on intrathoracic findings |
| title_full_unstemmed | Prognosis of resected non-small cell lung cancer with pleural plaques on intrathoracic findings |
| title_short | Prognosis of resected non-small cell lung cancer with pleural plaques on intrathoracic findings |
| title_sort | prognosis of resected non small cell lung cancer with pleural plaques on intrathoracic findings |
| topic | Pleural plaques Non-small cell lung cancer Asbestos Lung cancer |
| url | https://doi.org/10.1186/s12885-022-09600-6 |
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