Chitosan-(poly)acrylic acid polyelectrolyte complexes: Enhanced mucoadhesion and sustained drug release in vaginal tablets
Polyelectrolyte complexes (PECs) have emerged as promising vehicles for medical applications, attributable to their non-toxicity, non-immunogenicity, and ability for controlled drug release. Notably, their inherent mucoadhesive properties are being leveraged for sustained drug delivery across mucosa...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-06-01
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| Series: | Carbohydrate Polymer Technologies and Applications |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666893924000604 |
| _version_ | 1797262812988309504 |
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| author | Ismin Zainol Abidin Emma J. Murphy Gustavo W. Fehrenbach Noel Gately Ian Major |
| author_facet | Ismin Zainol Abidin Emma J. Murphy Gustavo W. Fehrenbach Noel Gately Ian Major |
| author_sort | Ismin Zainol Abidin |
| collection | DOAJ |
| description | Polyelectrolyte complexes (PECs) have emerged as promising vehicles for medical applications, attributable to their non-toxicity, non-immunogenicity, and ability for controlled drug release. Notably, their inherent mucoadhesive properties are being leveraged for sustained drug delivery across mucosal barriers, including vaginal, ocular, nasal, and buccal membranes. This study delves into the formulation and effects of chitosan-(poly)acrylic acid-based PEC for vaginal tablet applications. A comparative analysis of various polymer combinations was conducted, emphasizing the differential impacts of low versus high-molecular weight chitosan. Results highlighted that PECs augmented the flowability of powder mixtures and bolstered the tablets' physical properties. Moreover, PEC-enhanced formulations exhibited a pronounced increase in swelling efficiency, with swelling index values reaching up to 92.67 % ± 1.90, ensuring structural integrity during dissolution. In ex vivo mucoadhesion tests, tablets from PEC mixes demonstrated extended adhesion, surpassing 48 h for certain formulations. The optimized PEC formulation successfully achieved sustained drug release while retaining tablet adhesion for the duration of the release period. |
| first_indexed | 2024-04-25T00:03:04Z |
| format | Article |
| id | doaj.art-c87127354b05447899da5940d306c166 |
| institution | Directory Open Access Journal |
| issn | 2666-8939 |
| language | English |
| last_indexed | 2024-04-25T00:03:04Z |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Carbohydrate Polymer Technologies and Applications |
| spelling | doaj.art-c87127354b05447899da5940d306c1662024-03-14T06:16:48ZengElsevierCarbohydrate Polymer Technologies and Applications2666-89392024-06-017100480Chitosan-(poly)acrylic acid polyelectrolyte complexes: Enhanced mucoadhesion and sustained drug release in vaginal tabletsIsmin Zainol Abidin0Emma J. Murphy1Gustavo W. Fehrenbach2Noel Gately3Ian Major4PRISM Research Institute, Technological University of the Shannon: Midlands Midwest, Athlone Campus, Westmeath, IrelandPRISM Research Institute, Technological University of the Shannon: Midlands Midwest, Athlone Campus, Westmeath, Ireland; Shannon Applied Biotechnology Centre, Department of Applied Science, Faculty of Applied Sciences and Technology, Technological University of the Shannon: Midlands Midwest, Moylish Campus, Limerick, Ireland; LIFE – Health and Biosciences Research Institute, Technological University of the Shannon, Midwest Campus, Limerick, IrelandPRISM Research Institute, Technological University of the Shannon: Midlands Midwest, Athlone Campus, Westmeath, Ireland; LIFE – Health and Biosciences Research Institute, Technological University of the Shannon, Midwest Campus, Limerick, IrelandPRISM Research Institute, Technological University of the Shannon: Midlands Midwest, Athlone Campus, Westmeath, IrelandPRISM Research Institute, Technological University of the Shannon: Midlands Midwest, Athlone Campus, Westmeath, Ireland; Corresponding author.Polyelectrolyte complexes (PECs) have emerged as promising vehicles for medical applications, attributable to their non-toxicity, non-immunogenicity, and ability for controlled drug release. Notably, their inherent mucoadhesive properties are being leveraged for sustained drug delivery across mucosal barriers, including vaginal, ocular, nasal, and buccal membranes. This study delves into the formulation and effects of chitosan-(poly)acrylic acid-based PEC for vaginal tablet applications. A comparative analysis of various polymer combinations was conducted, emphasizing the differential impacts of low versus high-molecular weight chitosan. Results highlighted that PECs augmented the flowability of powder mixtures and bolstered the tablets' physical properties. Moreover, PEC-enhanced formulations exhibited a pronounced increase in swelling efficiency, with swelling index values reaching up to 92.67 % ± 1.90, ensuring structural integrity during dissolution. In ex vivo mucoadhesion tests, tablets from PEC mixes demonstrated extended adhesion, surpassing 48 h for certain formulations. The optimized PEC formulation successfully achieved sustained drug release while retaining tablet adhesion for the duration of the release period.http://www.sciencedirect.com/science/article/pii/S2666893924000604Polyelectrolyte complexChitosan(Poly)acrylic acidMucoadhesive vaginal tabletSustained releaseSwelling |
| spellingShingle | Ismin Zainol Abidin Emma J. Murphy Gustavo W. Fehrenbach Noel Gately Ian Major Chitosan-(poly)acrylic acid polyelectrolyte complexes: Enhanced mucoadhesion and sustained drug release in vaginal tablets Carbohydrate Polymer Technologies and Applications Polyelectrolyte complex Chitosan (Poly)acrylic acid Mucoadhesive vaginal tablet Sustained release Swelling |
| title | Chitosan-(poly)acrylic acid polyelectrolyte complexes: Enhanced mucoadhesion and sustained drug release in vaginal tablets |
| title_full | Chitosan-(poly)acrylic acid polyelectrolyte complexes: Enhanced mucoadhesion and sustained drug release in vaginal tablets |
| title_fullStr | Chitosan-(poly)acrylic acid polyelectrolyte complexes: Enhanced mucoadhesion and sustained drug release in vaginal tablets |
| title_full_unstemmed | Chitosan-(poly)acrylic acid polyelectrolyte complexes: Enhanced mucoadhesion and sustained drug release in vaginal tablets |
| title_short | Chitosan-(poly)acrylic acid polyelectrolyte complexes: Enhanced mucoadhesion and sustained drug release in vaginal tablets |
| title_sort | chitosan poly acrylic acid polyelectrolyte complexes enhanced mucoadhesion and sustained drug release in vaginal tablets |
| topic | Polyelectrolyte complex Chitosan (Poly)acrylic acid Mucoadhesive vaginal tablet Sustained release Swelling |
| url | http://www.sciencedirect.com/science/article/pii/S2666893924000604 |
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