Milk Antiviral Proteins and Derived Peptides against Zoonoses
Milk is renowned for its nutritional richness but also serves as a remarkable reservoir of bioactive compounds, particularly milk proteins and their derived peptides. Recent studies have showcased several robust antiviral activities of these proteins, evidencing promising potential within zoonotic v...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/25/3/1842 |
| _version_ | 1797318624036257792 |
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| author | Isabel Santos Mariana Silva Madalena Grácio Laurentina Pedroso Ana Lima |
| author_facet | Isabel Santos Mariana Silva Madalena Grácio Laurentina Pedroso Ana Lima |
| author_sort | Isabel Santos |
| collection | DOAJ |
| description | Milk is renowned for its nutritional richness but also serves as a remarkable reservoir of bioactive compounds, particularly milk proteins and their derived peptides. Recent studies have showcased several robust antiviral activities of these proteins, evidencing promising potential within zoonotic viral diseases. While several publications focus on milk’s bioactivities, antiviral peptides remain largely neglected in reviews. This knowledge is critical for identifying novel research directions and analyzing potential nutraceuticals within the One Health context. Our review aims to gather the existing scientific information on milk-derived antiviral proteins and peptides against several zoonotic viral diseases, and their possible mechanisms. Overall, in-depth research has increasingly revealed them as a promising and novel strategy against viruses, principally for those constituting a plausible pandemic threat. The underlying mechanisms of the bioactivity of milk’s proteins include inhibiting viral entry and attachment to the host cells, blocking replication, or even viral inactivation via peptide–membrane interactions. Their marked versatility and effectiveness stand out compared to other antiviral peptides and can support future research and development in the post-COVID-19 era. Overall, our review helps to emphasize the importance of potentially effective milk-derived peptides, and their significance for veterinary and human medicines, along with the pharmaceutical, nutraceutical, and dairy industry. |
| first_indexed | 2024-03-08T03:55:01Z |
| format | Article |
| id | doaj.art-c87459d4fd6f4ed89c78a397695eeaba |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-08T03:55:01Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-c87459d4fd6f4ed89c78a397695eeaba2024-02-09T15:14:50ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672024-02-01253184210.3390/ijms25031842Milk Antiviral Proteins and Derived Peptides against ZoonosesIsabel Santos0Mariana Silva1Madalena Grácio2Laurentina Pedroso3Ana Lima4Faculty of Veterinary Medicine, Lusófona University, 376 Campo Grande, 1749-024 Lisbon, PortugalFaculty of Veterinary Medicine, Lusófona University, 376 Campo Grande, 1749-024 Lisbon, PortugalInstituto Superior de Agronomia, Universidade de Lisboa, Tapada da Ajuda, 1349-017 Lisbon, PortugalFaculty of Veterinary Medicine, Lusófona University, 376 Campo Grande, 1749-024 Lisbon, PortugalFaculty of Veterinary Medicine, Lusófona University, 376 Campo Grande, 1749-024 Lisbon, PortugalMilk is renowned for its nutritional richness but also serves as a remarkable reservoir of bioactive compounds, particularly milk proteins and their derived peptides. Recent studies have showcased several robust antiviral activities of these proteins, evidencing promising potential within zoonotic viral diseases. While several publications focus on milk’s bioactivities, antiviral peptides remain largely neglected in reviews. This knowledge is critical for identifying novel research directions and analyzing potential nutraceuticals within the One Health context. Our review aims to gather the existing scientific information on milk-derived antiviral proteins and peptides against several zoonotic viral diseases, and their possible mechanisms. Overall, in-depth research has increasingly revealed them as a promising and novel strategy against viruses, principally for those constituting a plausible pandemic threat. The underlying mechanisms of the bioactivity of milk’s proteins include inhibiting viral entry and attachment to the host cells, blocking replication, or even viral inactivation via peptide–membrane interactions. Their marked versatility and effectiveness stand out compared to other antiviral peptides and can support future research and development in the post-COVID-19 era. Overall, our review helps to emphasize the importance of potentially effective milk-derived peptides, and their significance for veterinary and human medicines, along with the pharmaceutical, nutraceutical, and dairy industry.https://www.mdpi.com/1422-0067/25/3/1842milkpeptideszoonosesantiviralone health |
| spellingShingle | Isabel Santos Mariana Silva Madalena Grácio Laurentina Pedroso Ana Lima Milk Antiviral Proteins and Derived Peptides against Zoonoses International Journal of Molecular Sciences milk peptides zoonoses antiviral one health |
| title | Milk Antiviral Proteins and Derived Peptides against Zoonoses |
| title_full | Milk Antiviral Proteins and Derived Peptides against Zoonoses |
| title_fullStr | Milk Antiviral Proteins and Derived Peptides against Zoonoses |
| title_full_unstemmed | Milk Antiviral Proteins and Derived Peptides against Zoonoses |
| title_short | Milk Antiviral Proteins and Derived Peptides against Zoonoses |
| title_sort | milk antiviral proteins and derived peptides against zoonoses |
| topic | milk peptides zoonoses antiviral one health |
| url | https://www.mdpi.com/1422-0067/25/3/1842 |
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