Antibiotic Administration within Two Days after Successful Endoscopic Retrograde Cholangiopancreatography Is Sufficient for Mild and Moderate Acute Cholangitis
To prevent the increase of resistant bacteria, it is important to minimize the use of antimicrobial agents. Studies have found that administration for ≤3 days after successful endoscopic retrograde cholangiopancreatography (ERCP) is appropriate. Therefore, the present study aimed to verify if admini...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/10/2697 |
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| author | Sakue Masuda Kazuya Koizumi Makomo Makazu Haruki Uojima Jun Kubota Karen Kimura Takashi Nishino Chihiro Sumida Chikamasa Ichita Akiko Sasaki Kento Shionoya |
| author_facet | Sakue Masuda Kazuya Koizumi Makomo Makazu Haruki Uojima Jun Kubota Karen Kimura Takashi Nishino Chihiro Sumida Chikamasa Ichita Akiko Sasaki Kento Shionoya |
| author_sort | Sakue Masuda |
| collection | DOAJ |
| description | To prevent the increase of resistant bacteria, it is important to minimize the use of antimicrobial agents. Studies have found that administration for ≤3 days after successful endoscopic retrograde cholangiopancreatography (ERCP) is appropriate. Therefore, the present study aimed to verify if administration of antimicrobial agents can be further shortened to ≤2 days after ERCP. We divided 390 patients with mild and moderate cholangitis who underwent technically successful ERCP from January 2018 to June 2020 and had positive blood or bile cultures into two groups: antibiotic therapy within two days of ERCP (short-course therapy, SCT; <i>n</i> = 59, 15.1%), and for >3 days (long-course therapy, LCT; <i>n</i> = 331, 84.9%). The increased severity after admission and other outcomes were compared between the two groups, and the risk factors for increased severity were verified. There were no between-group differences in patient characteristics. Total length of hospital stay was shorter in SCT than in LCT, and other outcomes in SCT were not significantly different from those in LCT. Being 80 or older was a risk factor for increased severity; however, SCT was not associated with increased severity. Antimicrobial therapy for ≤2 days after successful ERCP is adequate in patients with mild and moderate acute cholangitis. |
| first_indexed | 2024-03-10T03:40:53Z |
| format | Article |
| id | doaj.art-c87498fb58de4d8698d4265e18140fae |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T03:40:53Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-c87498fb58de4d8698d4265e18140fae2023-11-23T11:33:24ZengMDPI AGJournal of Clinical Medicine2077-03832022-05-011110269710.3390/jcm11102697Antibiotic Administration within Two Days after Successful Endoscopic Retrograde Cholangiopancreatography Is Sufficient for Mild and Moderate Acute CholangitisSakue Masuda0Kazuya Koizumi1Makomo Makazu2Haruki Uojima3Jun Kubota4Karen Kimura5Takashi Nishino6Chihiro Sumida7Chikamasa Ichita8Akiko Sasaki9Kento Shionoya10Department of Gastroenterology Medicine Center, Shonan Kamakura General Hospital, 1370-1 Okamoto, Kamakura 247-8533, JapanDepartment of Gastroenterology Medicine Center, Shonan Kamakura General Hospital, 1370-1 Okamoto, Kamakura 247-8533, JapanDepartment of Gastroenterology Medicine Center, Shonan Kamakura General Hospital, 1370-1 Okamoto, Kamakura 247-8533, JapanDepartment of Gastroenterology, Internal Medicine, School of Medicine, Kitasato University, Sagamihara 252-0375, JapanDepartment of Gastroenterology Medicine Center, Shonan Kamakura General Hospital, 1370-1 Okamoto, Kamakura 247-8533, JapanDepartment of Gastroenterology Medicine Center, Shonan Kamakura General Hospital, 1370-1 Okamoto, Kamakura 247-8533, JapanDepartment of Gastroenterology Medicine Center, Shonan Kamakura General Hospital, 1370-1 Okamoto, Kamakura 247-8533, JapanDepartment of Gastroenterology Medicine Center, Shonan Kamakura General Hospital, 1370-1 Okamoto, Kamakura 247-8533, JapanDepartment of Gastroenterology Medicine Center, Shonan Kamakura General Hospital, 1370-1 Okamoto, Kamakura 247-8533, JapanDepartment of Gastroenterology Medicine Center, Shonan Kamakura General Hospital, 1370-1 Okamoto, Kamakura 247-8533, JapanDepartment of Gastroenterology Medicine Center, Shonan Kamakura General Hospital, 1370-1 Okamoto, Kamakura 247-8533, JapanTo prevent the increase of resistant bacteria, it is important to minimize the use of antimicrobial agents. Studies have found that administration for ≤3 days after successful endoscopic retrograde cholangiopancreatography (ERCP) is appropriate. Therefore, the present study aimed to verify if administration of antimicrobial agents can be further shortened to ≤2 days after ERCP. We divided 390 patients with mild and moderate cholangitis who underwent technically successful ERCP from January 2018 to June 2020 and had positive blood or bile cultures into two groups: antibiotic therapy within two days of ERCP (short-course therapy, SCT; <i>n</i> = 59, 15.1%), and for >3 days (long-course therapy, LCT; <i>n</i> = 331, 84.9%). The increased severity after admission and other outcomes were compared between the two groups, and the risk factors for increased severity were verified. There were no between-group differences in patient characteristics. Total length of hospital stay was shorter in SCT than in LCT, and other outcomes in SCT were not significantly different from those in LCT. Being 80 or older was a risk factor for increased severity; however, SCT was not associated with increased severity. Antimicrobial therapy for ≤2 days after successful ERCP is adequate in patients with mild and moderate acute cholangitis.https://www.mdpi.com/2077-0383/11/10/2697antibioticsantimicrobial stewardshipshort-course antimicrobialscholangitisendoscopic retrograde cholangiopancreatography |
| spellingShingle | Sakue Masuda Kazuya Koizumi Makomo Makazu Haruki Uojima Jun Kubota Karen Kimura Takashi Nishino Chihiro Sumida Chikamasa Ichita Akiko Sasaki Kento Shionoya Antibiotic Administration within Two Days after Successful Endoscopic Retrograde Cholangiopancreatography Is Sufficient for Mild and Moderate Acute Cholangitis Journal of Clinical Medicine antibiotics antimicrobial stewardship short-course antimicrobials cholangitis endoscopic retrograde cholangiopancreatography |
| title | Antibiotic Administration within Two Days after Successful Endoscopic Retrograde Cholangiopancreatography Is Sufficient for Mild and Moderate Acute Cholangitis |
| title_full | Antibiotic Administration within Two Days after Successful Endoscopic Retrograde Cholangiopancreatography Is Sufficient for Mild and Moderate Acute Cholangitis |
| title_fullStr | Antibiotic Administration within Two Days after Successful Endoscopic Retrograde Cholangiopancreatography Is Sufficient for Mild and Moderate Acute Cholangitis |
| title_full_unstemmed | Antibiotic Administration within Two Days after Successful Endoscopic Retrograde Cholangiopancreatography Is Sufficient for Mild and Moderate Acute Cholangitis |
| title_short | Antibiotic Administration within Two Days after Successful Endoscopic Retrograde Cholangiopancreatography Is Sufficient for Mild and Moderate Acute Cholangitis |
| title_sort | antibiotic administration within two days after successful endoscopic retrograde cholangiopancreatography is sufficient for mild and moderate acute cholangitis |
| topic | antibiotics antimicrobial stewardship short-course antimicrobials cholangitis endoscopic retrograde cholangiopancreatography |
| url | https://www.mdpi.com/2077-0383/11/10/2697 |
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