Phenotypic and genome-wide studies on dicarbonyls: major associations to glomerular filtration rate and gamma-glutamyltransferase activityResearch in context

Phenotypic and genome-wide studies on dicarbonyls: major associations to glomerular filtration rate and gamma-glutamyltransferase activityResearch in context

Summary: Background: The dicarbonyl compounds methylglyoxal (MG), glyoxal (GO) and 3-deoxyglucosone (3-DG) have been linked to various diseases. However, disease-independent phenotypic and genotypic association studies with phenome-wide and genome-wide reach, respectively, have not been provided. M...

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Bibliographic Details
Main Authors: Philip Harrer, Julica Inderhees, Chen Zhao, Barbara Schormair, Erik Tilch, Christian Gieger, Annette Peters, Olaf Jöhren, Thomas Fleming, Peter P. Nawroth, Klaus Berger, Marco Hermesdorf, Juliane Winkelmann, Markus Schwaninger, Konrad Oexle
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:EBioMedicine
Subjects:
Dicarbonyl compounds
Phenotypic association study
Genome-wide association study
Kidney function
Liver enzymes
Glucose
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396424000422

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http://www.sciencedirect.com/science/article/pii/S2352396424000422

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