Association Between Patients’ Immunoglobulin E Levels and Difficulty Eradicating Helicobacter pylori
Kayoko Ozeki,1,2 Takahisa Furuta,3 Toshiyuki Ojima1 1Department of Community Health and Preventive Medicine, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan; 2Department of Pharmaceutical Health Care and Science, Aichi Gakuin University, Nagoya, Aichi, Japan; 3Center for Clinical...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2021-07-01
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| Series: | Clinical and Experimental Gastroenterology |
| Subjects: | |
| Online Access: | https://www.dovepress.com/association-between-patients-immunoglobulin-e-levels-and-difficulty-er-peer-reviewed-fulltext-article-CEG |
| _version_ | 1818923965178970112 |
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| author | Ozeki K Furuta T Ojima T |
| author_facet | Ozeki K Furuta T Ojima T |
| author_sort | Ozeki K |
| collection | DOAJ |
| description | Kayoko Ozeki,1,2 Takahisa Furuta,3 Toshiyuki Ojima1 1Department of Community Health and Preventive Medicine, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan; 2Department of Pharmaceutical Health Care and Science, Aichi Gakuin University, Nagoya, Aichi, Japan; 3Center for Clinical Research, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, JapanCorrespondence: Kayoko OzekiDepartment of Community Health and Preventive Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashiku, Hamamatsu, Shizuoka, 431-3192, JapanTel +81 53 435 2333Fax +81 53 435 2341Email kozeki@dpc.agu.ac.jpBackground: Helicobacter pylori is a cause of gastric cancer, and thus the eradication of this bacterium is very important. The success rate of primary eradication has been dramatically increased by the introduction of potassium-competitive acid blockers. However, H. pylori cannot be eradicated in all patients, and the contributing factors need to be clarified.Aim: Because allergy status may be a factor and considering research linking hay fever with eradication failure, the purpose of this study was to examine blood immunoglobulin E levels as a contributing factor in patients who were unable to eradicate H. pylori in a single eradication treatment and who underwent multiple eradication attempts.Methods: Questionnaire data were collected from 250 patients who visited the Department of Gastroenterology, Hamamatsu University School of Medicine, for H. pylori eradication. In addition, non-specific IgE levels in the blood were measured and analyzed with one-way analysis of variance. Multinomial logistic regression analysis was performed to examine the association between the number of eradication attempts and the IgE level (< 500 vs ≥ 500 IU/mL).Results: The mean IgE values were 188.4, 211.9, and 744.0 IU/mL in patients with one, two, and three or more eradication attempts, respectively (P < 0.05). The results of multinomial logistic regression analysis showed that attempting eradication three or more times was significantly associated with high levels of IgE, even after consideration of antibiotic sensitivity.Conclusion: H. pylori eradication was less likely in patients with high IgE. It is thus necessary to study the appropriate regimen for patients with high IgE levels.Keywords: Helicobacter pylori, multiple eradication, antibiotic sensitivity |
| first_indexed | 2024-12-20T02:17:49Z |
| format | Article |
| id | doaj.art-c87781ce5ca5474290cdffc1bc227690 |
| institution | Directory Open Access Journal |
| issn | 1178-7023 |
| language | English |
| last_indexed | 2024-12-20T02:17:49Z |
| publishDate | 2021-07-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical and Experimental Gastroenterology |
| spelling | doaj.art-c87781ce5ca5474290cdffc1bc2276902022-12-21T19:56:54ZengDove Medical PressClinical and Experimental Gastroenterology1178-70232021-07-01Volume 1431131667351Association Between Patients’ Immunoglobulin E Levels and Difficulty Eradicating Helicobacter pyloriOzeki KFuruta TOjima TKayoko Ozeki,1,2 Takahisa Furuta,3 Toshiyuki Ojima1 1Department of Community Health and Preventive Medicine, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan; 2Department of Pharmaceutical Health Care and Science, Aichi Gakuin University, Nagoya, Aichi, Japan; 3Center for Clinical Research, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, JapanCorrespondence: Kayoko OzekiDepartment of Community Health and Preventive Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashiku, Hamamatsu, Shizuoka, 431-3192, JapanTel +81 53 435 2333Fax +81 53 435 2341Email kozeki@dpc.agu.ac.jpBackground: Helicobacter pylori is a cause of gastric cancer, and thus the eradication of this bacterium is very important. The success rate of primary eradication has been dramatically increased by the introduction of potassium-competitive acid blockers. However, H. pylori cannot be eradicated in all patients, and the contributing factors need to be clarified.Aim: Because allergy status may be a factor and considering research linking hay fever with eradication failure, the purpose of this study was to examine blood immunoglobulin E levels as a contributing factor in patients who were unable to eradicate H. pylori in a single eradication treatment and who underwent multiple eradication attempts.Methods: Questionnaire data were collected from 250 patients who visited the Department of Gastroenterology, Hamamatsu University School of Medicine, for H. pylori eradication. In addition, non-specific IgE levels in the blood were measured and analyzed with one-way analysis of variance. Multinomial logistic regression analysis was performed to examine the association between the number of eradication attempts and the IgE level (< 500 vs ≥ 500 IU/mL).Results: The mean IgE values were 188.4, 211.9, and 744.0 IU/mL in patients with one, two, and three or more eradication attempts, respectively (P < 0.05). The results of multinomial logistic regression analysis showed that attempting eradication three or more times was significantly associated with high levels of IgE, even after consideration of antibiotic sensitivity.Conclusion: H. pylori eradication was less likely in patients with high IgE. It is thus necessary to study the appropriate regimen for patients with high IgE levels.Keywords: Helicobacter pylori, multiple eradication, antibiotic sensitivityhttps://www.dovepress.com/association-between-patients-immunoglobulin-e-levels-and-difficulty-er-peer-reviewed-fulltext-article-CEGhelicobacter pylorimultiple eradicationantibiotic sensitivity |
| spellingShingle | Ozeki K Furuta T Ojima T Association Between Patients’ Immunoglobulin E Levels and Difficulty Eradicating Helicobacter pylori Clinical and Experimental Gastroenterology helicobacter pylori multiple eradication antibiotic sensitivity |
| title | Association Between Patients’ Immunoglobulin E Levels and Difficulty Eradicating Helicobacter pylori |
| title_full | Association Between Patients’ Immunoglobulin E Levels and Difficulty Eradicating Helicobacter pylori |
| title_fullStr | Association Between Patients’ Immunoglobulin E Levels and Difficulty Eradicating Helicobacter pylori |
| title_full_unstemmed | Association Between Patients’ Immunoglobulin E Levels and Difficulty Eradicating Helicobacter pylori |
| title_short | Association Between Patients’ Immunoglobulin E Levels and Difficulty Eradicating Helicobacter pylori |
| title_sort | association between patients rsquo immunoglobulin e levels and difficulty eradicating helicobacter pylori |
| topic | helicobacter pylori multiple eradication antibiotic sensitivity |
| url | https://www.dovepress.com/association-between-patients-immunoglobulin-e-levels-and-difficulty-er-peer-reviewed-fulltext-article-CEG |
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