Quality of Life After Stereotactic Body Radiation Therapy or Surgery for Early-Stage NSCLC: A Systematic ReviewKey Points
Quality of life (QOL) is a key consideration for patients with early-stage NSCLC choosing between treatment options. Currently, it is not well established whether stereotactic body radiation therapy (SBRT) or surgery offers superior QOL in early-stage NSCLC. The objective of this systematic review i...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-11-01
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| Series: | JTO Clinical and Research Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666364322001412 |
| _version_ | 1811212074143973376 |
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| author | Austin J. Iovoli, MD Brian Yu, BSc Sung Jun Ma, MD Mark K. Farrugia, MD, PhD Elizabeth U. Dexter, MD Sai Yendamuri, MD Elizabeth G. Bouchard, PhD Anurag K. Singh, MD |
| author_facet | Austin J. Iovoli, MD Brian Yu, BSc Sung Jun Ma, MD Mark K. Farrugia, MD, PhD Elizabeth U. Dexter, MD Sai Yendamuri, MD Elizabeth G. Bouchard, PhD Anurag K. Singh, MD |
| author_sort | Austin J. Iovoli, MD |
| collection | DOAJ |
| description | Quality of life (QOL) is a key consideration for patients with early-stage NSCLC choosing between treatment options. Currently, it is not well established whether stereotactic body radiation therapy (SBRT) or surgery offers superior QOL in early-stage NSCLC. The objective of this systematic review is to summarize the prospective literature on QOL in patients with early-stage NSCLC after treatment with SBRT or surgery. A comprehensive literature review using PubMed and EMBASE was performed in April 2022. Prospective studies evaluating QOL data across multiple time points in patients with early-stage NSCLC after SBRT or surgery were included. A total of 25 studies involving 1597 SBRT patients and 1652 surgery patients met the inclusion criteria. Across most studies, QOL remained stable after treatment with SBRT. After surgery, QOL initially decreased; however, it often returned to baseline in the next 6 to 12 months. Utilization of video-assisted thoracoscopic surgery and sublobar resection reduced the magnitude of the initial decrease in QOL after surgery and led to faster recovery to baseline. Owing to the heterogeneity of patient populations between studies evaluating SBRT versus surgery, direct comparisons between the two treatments remain difficult to make. Clinicians should appropriately counsel patients with this information to help guide patient-centered discussions on choosing the optimal treatment modality. |
| first_indexed | 2024-04-12T05:22:51Z |
| format | Article |
| id | doaj.art-c878c0d1c5034a83b6bf6d97db1a8127 |
| institution | Directory Open Access Journal |
| issn | 2666-3643 |
| language | English |
| last_indexed | 2024-04-12T05:22:51Z |
| publishDate | 2022-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | JTO Clinical and Research Reports |
| spelling | doaj.art-c878c0d1c5034a83b6bf6d97db1a81272022-12-22T03:46:24ZengElsevierJTO Clinical and Research Reports2666-36432022-11-01311100417Quality of Life After Stereotactic Body Radiation Therapy or Surgery for Early-Stage NSCLC: A Systematic ReviewKey PointsAustin J. Iovoli, MD0Brian Yu, BSc1Sung Jun Ma, MD2Mark K. Farrugia, MD, PhD3Elizabeth U. Dexter, MD4Sai Yendamuri, MD5Elizabeth G. Bouchard, PhD6Anurag K. Singh, MD7Department of Radiation Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, New YorkJacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, New YorkDepartment of Radiation Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, New YorkDepartment of Radiation Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, New YorkDepartment of Thoracic Surgery, Roswell Park Comprehensive Cancer Center, Buffalo, New YorkDepartment of Thoracic Surgery, Roswell Park Comprehensive Cancer Center, Buffalo, New YorkDepartment of Cancer Prevention & Control, Roswell Park Comprehensive Cancer Center, Buffalo, New YorkDepartment of Radiation Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, New York; Corresponding author. Address for correspondence: Anurag K. Singh, MD, Department of Radiation Medicine, Roswell Park Comprehensive Cancer Center, 665 Elm Street, Buffalo, NY 14203.Quality of life (QOL) is a key consideration for patients with early-stage NSCLC choosing between treatment options. Currently, it is not well established whether stereotactic body radiation therapy (SBRT) or surgery offers superior QOL in early-stage NSCLC. The objective of this systematic review is to summarize the prospective literature on QOL in patients with early-stage NSCLC after treatment with SBRT or surgery. A comprehensive literature review using PubMed and EMBASE was performed in April 2022. Prospective studies evaluating QOL data across multiple time points in patients with early-stage NSCLC after SBRT or surgery were included. A total of 25 studies involving 1597 SBRT patients and 1652 surgery patients met the inclusion criteria. Across most studies, QOL remained stable after treatment with SBRT. After surgery, QOL initially decreased; however, it often returned to baseline in the next 6 to 12 months. Utilization of video-assisted thoracoscopic surgery and sublobar resection reduced the magnitude of the initial decrease in QOL after surgery and led to faster recovery to baseline. Owing to the heterogeneity of patient populations between studies evaluating SBRT versus surgery, direct comparisons between the two treatments remain difficult to make. Clinicians should appropriately counsel patients with this information to help guide patient-centered discussions on choosing the optimal treatment modality.http://www.sciencedirect.com/science/article/pii/S2666364322001412Lung cancerSystematic reviewQuality of lifeSBRTNSCLCSurgery |
| spellingShingle | Austin J. Iovoli, MD Brian Yu, BSc Sung Jun Ma, MD Mark K. Farrugia, MD, PhD Elizabeth U. Dexter, MD Sai Yendamuri, MD Elizabeth G. Bouchard, PhD Anurag K. Singh, MD Quality of Life After Stereotactic Body Radiation Therapy or Surgery for Early-Stage NSCLC: A Systematic ReviewKey Points JTO Clinical and Research Reports Lung cancer Systematic review Quality of life SBRT NSCLC Surgery |
| title | Quality of Life After Stereotactic Body Radiation Therapy or Surgery for Early-Stage NSCLC: A Systematic ReviewKey Points |
| title_full | Quality of Life After Stereotactic Body Radiation Therapy or Surgery for Early-Stage NSCLC: A Systematic ReviewKey Points |
| title_fullStr | Quality of Life After Stereotactic Body Radiation Therapy or Surgery for Early-Stage NSCLC: A Systematic ReviewKey Points |
| title_full_unstemmed | Quality of Life After Stereotactic Body Radiation Therapy or Surgery for Early-Stage NSCLC: A Systematic ReviewKey Points |
| title_short | Quality of Life After Stereotactic Body Radiation Therapy or Surgery for Early-Stage NSCLC: A Systematic ReviewKey Points |
| title_sort | quality of life after stereotactic body radiation therapy or surgery for early stage nsclc a systematic reviewkey points |
| topic | Lung cancer Systematic review Quality of life SBRT NSCLC Surgery |
| url | http://www.sciencedirect.com/science/article/pii/S2666364322001412 |
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