FKBP51 mediates resilience to inflammation-induced anxiety through regulation of glutamic acid decarboxylase 65 expression in mouse hippocampus

FKBP51 mediates resilience to inflammation-induced anxiety through regulation of glutamic acid decarboxylase 65 expression in mouse hippocampus

Abstract Background Inflammation is a potential risk factor of mental disturbance. FKBP5 that encodes FK506-binding protein 51 (FKBP51), a negative cochaperone of glucocorticoid receptor (GR), is a stress-inducible gene and has been linked to psychiatric disorders. Yet, the role of FKBP51 in the inf...

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Main Authors: Yu-Ling Gan, Chen-Yu Wang, Rong-Heng He, Pei-Chien Hsu, Hsin-Hsien Yeh, Tsung-Han Hsieh, Hui-Ching Lin, Ming-Yen Cheng, Chung-Jiuan Jeng, Ming-Chyi Huang, Yi-Hsuan Lee
Format: Article
Language:English
Published: BMC 2022-06-01
Series:Journal of Neuroinflammation
Subjects:
FK506-binding protein 51 (FKBP51)
Inflammation
Anxiety
Resilience
Glucocorticoid receptor
Glutamic acid decarboxylase 65 (GAD65)
Online Access:https://doi.org/10.1186/s12974-022-02517-8

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