Diagnostic challenges of lung biopsies in setting of metastatic female genital tract tumors; report of 2 cases
Introduction: Lungs are one of the most common sites for metastatic tumors in the body. In addition, primary lung tumors are the most common cause of death due to neoplasms in both genders. Treatment strategies are completely different for primary and metastatic lung tumors making accurate diagnosis...
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| Format: | Article |
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Ilam University of Medical Sciences
2023-09-01
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| Series: | Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām |
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| Online Access: | http://sjimu.medilam.ac.ir/article-1-7950-en.pdf |
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| author | Fazaneh Fazli Khalaf Vahid Soleimani Tahere Yousefi Shahab Rafieian Behnaz Jahanbin Sara Rokn |
| author_facet | Fazaneh Fazli Khalaf Vahid Soleimani Tahere Yousefi Shahab Rafieian Behnaz Jahanbin Sara Rokn |
| author_sort | Fazaneh Fazli Khalaf |
| collection | DOAJ |
| description | Introduction: Lungs are one of the most common sites for metastatic tumors in the body. In addition, primary lung tumors are the most common cause of death due to neoplasms in both genders. Treatment strategies are completely different for primary and metastatic lung tumors making accurate diagnosis of lung tumors an effective factor in planning the correct treatment. The development of personalized medicine and targeted therapy, especially in the treatment of primary lung tumors, has highlighted the importance of correct diagnosis of these tumors.
Case report: The Pathology Center of Imam Khomeini Hospital Cancer Institute in Tehran, Iran, as a referral center for cancer across the country, is faced with a large number of lung biopsies, and therefore, there will be numerous diagnostic challenges. In this article, we presented two cases of primary female genital tract (cervical) tumors that during follow up lung masses were detected. Diagnosis on lung biopsy assigned as primary lung adenocarcinoma. Both cases referred to our lab for second opinion accompanied with related resected sample and implementation of further supplementary markers documented metastatic origin of tumors.
Discussion & conclusion: In both cases, similarity in immunohistochemical characteristics of metastatic tumors with primary lung adenocarcinoma, especially positive nuclear TTF1 staining led to misdiagnosis of lung tumor origin. This finding emphasizes on the use of other specific markers related to primary site of tumor to decrease possibility of incorrect diagnosis of the origin of the tumor in metastatic setting. Due to remarkable influence of primary versus metastatic origin of lung tumor on selection of treatment, pathologists should be considered correct diagnosis and notice to similarity of immunohistochemical markers of primary lung tumors to other organs and implementation of more specific markers are necessary. |
| first_indexed | 2024-03-11T23:34:11Z |
| format | Article |
| id | doaj.art-c879fd64ab634a7695a637f81c028d5c |
| institution | Directory Open Access Journal |
| issn | 1563-4728 2588-3135 |
| language | fas |
| last_indexed | 2024-03-11T23:34:11Z |
| publishDate | 2023-09-01 |
| publisher | Ilam University of Medical Sciences |
| record_format | Article |
| series | Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām |
| spelling | doaj.art-c879fd64ab634a7695a637f81c028d5c2023-09-20T05:53:44ZfasIlam University of Medical SciencesMajallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām1563-47282588-31352023-09-0131318Diagnostic challenges of lung biopsies in setting of metastatic female genital tract tumors; report of 2 casesFazaneh Fazli Khalaf0Vahid Soleimani1Tahere Yousefi2Shahab Rafieian3Behnaz Jahanbin4Sara Rokn5 Dept of Pathology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran Dept of Pathology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran Dept of Pathology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran Dept of Thoracic Surgery, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran Dept of Pathology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran Dept of Chemistry and Biochemistry, University of Windsor, Ontario, Canada Introduction: Lungs are one of the most common sites for metastatic tumors in the body. In addition, primary lung tumors are the most common cause of death due to neoplasms in both genders. Treatment strategies are completely different for primary and metastatic lung tumors making accurate diagnosis of lung tumors an effective factor in planning the correct treatment. The development of personalized medicine and targeted therapy, especially in the treatment of primary lung tumors, has highlighted the importance of correct diagnosis of these tumors. Case report: The Pathology Center of Imam Khomeini Hospital Cancer Institute in Tehran, Iran, as a referral center for cancer across the country, is faced with a large number of lung biopsies, and therefore, there will be numerous diagnostic challenges. In this article, we presented two cases of primary female genital tract (cervical) tumors that during follow up lung masses were detected. Diagnosis on lung biopsy assigned as primary lung adenocarcinoma. Both cases referred to our lab for second opinion accompanied with related resected sample and implementation of further supplementary markers documented metastatic origin of tumors. Discussion & conclusion: In both cases, similarity in immunohistochemical characteristics of metastatic tumors with primary lung adenocarcinoma, especially positive nuclear TTF1 staining led to misdiagnosis of lung tumor origin. This finding emphasizes on the use of other specific markers related to primary site of tumor to decrease possibility of incorrect diagnosis of the origin of the tumor in metastatic setting. Due to remarkable influence of primary versus metastatic origin of lung tumor on selection of treatment, pathologists should be considered correct diagnosis and notice to similarity of immunohistochemical markers of primary lung tumors to other organs and implementation of more specific markers are necessary.http://sjimu.medilam.ac.ir/article-1-7950-en.pdflung tumorsmetastatic tumorsimmunohistochemistryttf1 |
| spellingShingle | Fazaneh Fazli Khalaf Vahid Soleimani Tahere Yousefi Shahab Rafieian Behnaz Jahanbin Sara Rokn Diagnostic challenges of lung biopsies in setting of metastatic female genital tract tumors; report of 2 cases Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām lung tumors metastatic tumors immunohistochemistry ttf1 |
| title | Diagnostic challenges of lung biopsies in setting of metastatic female genital tract tumors; report of 2 cases |
| title_full | Diagnostic challenges of lung biopsies in setting of metastatic female genital tract tumors; report of 2 cases |
| title_fullStr | Diagnostic challenges of lung biopsies in setting of metastatic female genital tract tumors; report of 2 cases |
| title_full_unstemmed | Diagnostic challenges of lung biopsies in setting of metastatic female genital tract tumors; report of 2 cases |
| title_short | Diagnostic challenges of lung biopsies in setting of metastatic female genital tract tumors; report of 2 cases |
| title_sort | diagnostic challenges of lung biopsies in setting of metastatic female genital tract tumors report of 2 cases |
| topic | lung tumors metastatic tumors immunohistochemistry ttf1 |
| url | http://sjimu.medilam.ac.ir/article-1-7950-en.pdf |
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