Metachronous Carcinomas of the Biliary Tract in a Patient Treated Three Times with Curative Surgery
We here report on a case of metachronous multicentric carcinomas of the biliary tract treated 3 times with curative surgery over 23 years. A 28-year-old woman underwent cholecystectomy because of papillary carcinoma of the gallbladder. After 17 years, 3 carcinomas developed in the biliary tract: int...
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| Format: | Article |
| Language: | English |
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Karger Publishers
2009-04-01
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| Series: | Case Reports in Gastroenterology |
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| Online Access: | http://www.karger.com/Article/FullText/208376 |
| _version_ | 1818144227156033536 |
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| author | Masanao Kurata Atsutake Okamoto Tomoyoshi Suzuki Gaku Matsumoto Koji Tsuruta Goro Honda Tetsuo Nemoto |
| author_facet | Masanao Kurata Atsutake Okamoto Tomoyoshi Suzuki Gaku Matsumoto Koji Tsuruta Goro Honda Tetsuo Nemoto |
| author_sort | Masanao Kurata |
| collection | DOAJ |
| description | We here report on a case of metachronous multicentric carcinomas of the biliary tract treated 3 times with curative surgery over 23 years. A 28-year-old woman underwent cholecystectomy because of papillary carcinoma of the gallbladder. After 17 years, 3 carcinomas developed in the biliary tract: intrahepatic cholangiocarcinoma of the left liver, common bile duct carcinoma, and remnant cystic duct carcinoma. They were successfully removed via left hepatectomy combined with pylorus-preserving pancreatoduodenectomy. Furthermore, another intrahepatic cholangiocarcinoma developed 6 years after the second surgery, which was removed again via partial resection of the posterior segment of the liver. Histological findings of carcinomas represented various grades of cell differentiation. No predisposition toward carcinogenesis was found, since neither pancreaticobiliary maljunction nor primary sclerosing cholangitis was present, and the overexpression of cyclooxygenase-2 was negative in all resected specimens. Close monitoring for recurrence is warranted for early detection of metachronous carcinoma that might be effectively treated with repeated resection. |
| first_indexed | 2024-12-11T11:44:12Z |
| format | Article |
| id | doaj.art-c87a998ed4614052828e0fa325c3d4f2 |
| institution | Directory Open Access Journal |
| issn | 1662-0631 |
| language | English |
| last_indexed | 2024-12-11T11:44:12Z |
| publishDate | 2009-04-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Gastroenterology |
| spelling | doaj.art-c87a998ed4614052828e0fa325c3d4f22022-12-22T01:08:31ZengKarger PublishersCase Reports in Gastroenterology1662-06312009-04-0131849110.1159/000208376208376Metachronous Carcinomas of the Biliary Tract in a Patient Treated Three Times with Curative SurgeryMasanao KurataAtsutake OkamotoTomoyoshi SuzukiGaku MatsumotoKoji TsurutaGoro HondaTetsuo NemotoWe here report on a case of metachronous multicentric carcinomas of the biliary tract treated 3 times with curative surgery over 23 years. A 28-year-old woman underwent cholecystectomy because of papillary carcinoma of the gallbladder. After 17 years, 3 carcinomas developed in the biliary tract: intrahepatic cholangiocarcinoma of the left liver, common bile duct carcinoma, and remnant cystic duct carcinoma. They were successfully removed via left hepatectomy combined with pylorus-preserving pancreatoduodenectomy. Furthermore, another intrahepatic cholangiocarcinoma developed 6 years after the second surgery, which was removed again via partial resection of the posterior segment of the liver. Histological findings of carcinomas represented various grades of cell differentiation. No predisposition toward carcinogenesis was found, since neither pancreaticobiliary maljunction nor primary sclerosing cholangitis was present, and the overexpression of cyclooxygenase-2 was negative in all resected specimens. Close monitoring for recurrence is warranted for early detection of metachronous carcinoma that might be effectively treated with repeated resection.http://www.karger.com/Article/FullText/208376Metachronous carcinomaCarcinoma of the biliary tractCOX-2 protein expressionRepeated resection |
| spellingShingle | Masanao Kurata Atsutake Okamoto Tomoyoshi Suzuki Gaku Matsumoto Koji Tsuruta Goro Honda Tetsuo Nemoto Metachronous Carcinomas of the Biliary Tract in a Patient Treated Three Times with Curative Surgery Case Reports in Gastroenterology Metachronous carcinoma Carcinoma of the biliary tract COX-2 protein expression Repeated resection |
| title | Metachronous Carcinomas of the Biliary Tract in a Patient Treated Three Times with Curative Surgery |
| title_full | Metachronous Carcinomas of the Biliary Tract in a Patient Treated Three Times with Curative Surgery |
| title_fullStr | Metachronous Carcinomas of the Biliary Tract in a Patient Treated Three Times with Curative Surgery |
| title_full_unstemmed | Metachronous Carcinomas of the Biliary Tract in a Patient Treated Three Times with Curative Surgery |
| title_short | Metachronous Carcinomas of the Biliary Tract in a Patient Treated Three Times with Curative Surgery |
| title_sort | metachronous carcinomas of the biliary tract in a patient treated three times with curative surgery |
| topic | Metachronous carcinoma Carcinoma of the biliary tract COX-2 protein expression Repeated resection |
| url | http://www.karger.com/Article/FullText/208376 |
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