New insights into the function of Interleukin-25 in disease pathogenesis
Abstract Interleukin-25 (IL-25), also known as IL-17E, is a cytokine belonging to the IL-17 family. IL-25 is abundantly expressed by Th2 cells and various kinds of epithelial cells. IL-25 is an alarm signal generated upon cell injury or tissue damage to activate immune cells through the interaction...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-04-01
|
| Series: | Biomarker Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40364-023-00474-9 |
| _version_ | 1797853675993956352 |
|---|---|
| author | Qingfang Yuan Na Peng Fan Xiao Xiaofei Shi Bo Zhu Ke Rui Jie Tian Liwei Lu |
| author_facet | Qingfang Yuan Na Peng Fan Xiao Xiaofei Shi Bo Zhu Ke Rui Jie Tian Liwei Lu |
| author_sort | Qingfang Yuan |
| collection | DOAJ |
| description | Abstract Interleukin-25 (IL-25), also known as IL-17E, is a cytokine belonging to the IL-17 family. IL-25 is abundantly expressed by Th2 cells and various kinds of epithelial cells. IL-25 is an alarm signal generated upon cell injury or tissue damage to activate immune cells through the interaction with IL-17RA and IL-17RB receptors. The binding of IL-25 to IL-17RA/IL-17RB complex not only initiates and maintains type 2 immunity but also regulates other immune cells (e.g., macrophages and mast cells) via various signaling pathways. It has been well-documented that IL-25 is critically involved in the development of allergic disorders (e.g., asthma). However, the roles of IL-25 in the pathogenesis of other diseases and the underlying mechanisms are still unclear. This review presents current evidence on the roles of IL-25 in cancers, allergic disorders, and autoimmune diseases. Moreover, we discuss the unanswered key questions underlying IL-25-mediated disease pathology, which will provide new insights into the targeted therapy of this cytokine in clinical treatment. |
| first_indexed | 2024-04-09T19:54:32Z |
| format | Article |
| id | doaj.art-c87cbdbb708c49868273debcecdf2c25 |
| institution | Directory Open Access Journal |
| issn | 2050-7771 |
| language | English |
| last_indexed | 2024-04-09T19:54:32Z |
| publishDate | 2023-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Biomarker Research |
| spelling | doaj.art-c87cbdbb708c49868273debcecdf2c252023-04-03T05:35:01ZengBMCBiomarker Research2050-77712023-04-0111111610.1186/s40364-023-00474-9New insights into the function of Interleukin-25 in disease pathogenesisQingfang Yuan0Na Peng1Fan Xiao2Xiaofei Shi3Bo Zhu4Ke Rui5Jie Tian6Liwei Lu7Institute of Medical Immunology, Affiliated Hospital of Jiangsu UniversityDepartment of Rheumatology, the Second People’s Hospital, Three Gorges UniversityDepartment of Pathology, Shenzhen Institute of Research and Innovation, The University of Hong Kong, Chongqing International Institute for ImmunologyDepartment of Rheumatology and Immunology, The First Affiliated Hospital, School of Medicine, Henan University of Science and TechnologyInstitute of Medical Immunology, Affiliated Hospital of Jiangsu UniversityInstitute of Medical Immunology, Affiliated Hospital of Jiangsu UniversityInstitute of Medical Immunology, Affiliated Hospital of Jiangsu UniversityDepartment of Rheumatology, the Second People’s Hospital, Three Gorges UniversityAbstract Interleukin-25 (IL-25), also known as IL-17E, is a cytokine belonging to the IL-17 family. IL-25 is abundantly expressed by Th2 cells and various kinds of epithelial cells. IL-25 is an alarm signal generated upon cell injury or tissue damage to activate immune cells through the interaction with IL-17RA and IL-17RB receptors. The binding of IL-25 to IL-17RA/IL-17RB complex not only initiates and maintains type 2 immunity but also regulates other immune cells (e.g., macrophages and mast cells) via various signaling pathways. It has been well-documented that IL-25 is critically involved in the development of allergic disorders (e.g., asthma). However, the roles of IL-25 in the pathogenesis of other diseases and the underlying mechanisms are still unclear. This review presents current evidence on the roles of IL-25 in cancers, allergic disorders, and autoimmune diseases. Moreover, we discuss the unanswered key questions underlying IL-25-mediated disease pathology, which will provide new insights into the targeted therapy of this cytokine in clinical treatment.https://doi.org/10.1186/s40364-023-00474-9IL-25(IL-17E)Autoimmune diseasesInflammationCancerClinical treatment |
| spellingShingle | Qingfang Yuan Na Peng Fan Xiao Xiaofei Shi Bo Zhu Ke Rui Jie Tian Liwei Lu New insights into the function of Interleukin-25 in disease pathogenesis Biomarker Research IL-25(IL-17E) Autoimmune diseases Inflammation Cancer Clinical treatment |
| title | New insights into the function of Interleukin-25 in disease pathogenesis |
| title_full | New insights into the function of Interleukin-25 in disease pathogenesis |
| title_fullStr | New insights into the function of Interleukin-25 in disease pathogenesis |
| title_full_unstemmed | New insights into the function of Interleukin-25 in disease pathogenesis |
| title_short | New insights into the function of Interleukin-25 in disease pathogenesis |
| title_sort | new insights into the function of interleukin 25 in disease pathogenesis |
| topic | IL-25(IL-17E) Autoimmune diseases Inflammation Cancer Clinical treatment |
| url | https://doi.org/10.1186/s40364-023-00474-9 |
| work_keys_str_mv | AT qingfangyuan newinsightsintothefunctionofinterleukin25indiseasepathogenesis AT napeng newinsightsintothefunctionofinterleukin25indiseasepathogenesis AT fanxiao newinsightsintothefunctionofinterleukin25indiseasepathogenesis AT xiaofeishi newinsightsintothefunctionofinterleukin25indiseasepathogenesis AT bozhu newinsightsintothefunctionofinterleukin25indiseasepathogenesis AT kerui newinsightsintothefunctionofinterleukin25indiseasepathogenesis AT jietian newinsightsintothefunctionofinterleukin25indiseasepathogenesis AT liweilu newinsightsintothefunctionofinterleukin25indiseasepathogenesis |