Prevalence of Self-Reported Anosmia and Ageusia in Elderly Patients Who Had Been Previously Hospitalized by SARS-CoV-2: The LONG-COVID-EXP Multicenter Study

We explored two different graph methods for visualizing the prevalence of self-reported post-COVID anosmia and ageusia in a large sample of individuals who had been previously hospitalized in five different hospitals. A cohort of 1266 previously hospitalized COVID-19 survivors participated. Particip...

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Bibliographic Details
Main Authors: César Fernández-de-las-Peñas, Ricardo Ortega-Santiago, Ignacio Cancela-Cilleruelo, Jorge Rodríguez-Jiménez, Stella Fuensalida-Novo, José D. Martín-Guerrero, Óscar J. Pellicer-Valero, Margarita Cigarán-Méndez
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Journal of Clinical Medicine
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Online Access:https://www.mdpi.com/2077-0383/12/13/4391
Description
Summary:We explored two different graph methods for visualizing the prevalence of self-reported post-COVID anosmia and ageusia in a large sample of individuals who had been previously hospitalized in five different hospitals. A cohort of 1266 previously hospitalized COVID-19 survivors participated. Participants were assessed at hospitalization (T0) and at three different follow-up periods: 8.4 (T1), 13.2 (T2), and 18.3 (T3) months after hospital discharge. They were asked about the presence of self-reported anosmia and ageusia that they attributed to infection. Anosmia was defined as a self-perceived feeling of complete loss of smell. Ageusia was defined as a self-perceived feeling of complete loss of taste. Data about hospitalization were recorded from medical records. The results revealed that the prevalence of anosmia decreased from 8.29% (<i>n</i> = 105) at hospitalization (T0), to 4.47% (<i>n</i> = 56) at T1, to 3.27% (<i>n</i> = 41) at T2, and 3.35% (<i>n</i> = 42) at T3. Similarly, the prevalence of ageusia was 7.10% (<i>n</i> = 89) at the onset of SARS-CoV-2 infection (T0), but decreased to 3.03% (<i>n</i> = 38) at T1, to 1.99% (<i>n</i> = 25) at T2, and 1.36% (<i>n</i> = 17) at T3. The Sankey plots showed that only 10 (0.8%) and 11 (0.88%) patients exhibited anosmia and ageusia throughout all the follow-ups. The exponential curves revealed a progressive decrease in prevalence, demonstrating that self-reported anosmia and ageusia improved in the years following hospitalization. The female sex (OR4.254, 95% CI 1.184–15.294) and sufferers of asthma (OR7.086, 95% CI 1.359–36.936) were factors associated with the development of anosmia at T2, whereas internal care unit admission was a protective factor (OR0.891, 95% CI 0.819–0.970) for developing anosmia at T2. The use of a graphical method, such as a Sankey plot, shows that post-COVID self-reported anosmia and ageusia exhibit fluctuations during the first years after SARS-CoV-2 infection. Additionally, self-reported anosmia and ageusia also show a decrease in prevalence during the first years after infection, as expressed by exponential bar plots. The female sex was associated with the development of post-COVID anosmia, but not ageusia, in our cohort of elderly patients previously hospitalized due to COVID-19.
ISSN:2077-0383