Bringing immunofocusing into focus
Abstract Immunofocusing is a strategy to create immunogens that redirect humoral immune responses towards a targeted epitope and away from non-desirable epitopes. Immunofocusing methods often aim to develop “universal” vaccines that provide broad protection against highly variant viruses such as inf...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-01-01
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| Series: | npj Vaccines |
| Online Access: | https://doi.org/10.1038/s41541-023-00792-x |
| _version_ | 1827382432621395968 |
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| author | Sriharshita Musunuri Payton A. B. Weidenbacher Peter S. Kim |
| author_facet | Sriharshita Musunuri Payton A. B. Weidenbacher Peter S. Kim |
| author_sort | Sriharshita Musunuri |
| collection | DOAJ |
| description | Abstract Immunofocusing is a strategy to create immunogens that redirect humoral immune responses towards a targeted epitope and away from non-desirable epitopes. Immunofocusing methods often aim to develop “universal” vaccines that provide broad protection against highly variant viruses such as influenza virus, human immunodeficiency virus (HIV-1), and most recently, severe acute respiratory syndrome coronavirus (SARS-CoV-2). We use existing examples to illustrate five main immunofocusing strategies—cross-strain boosting, mosaic display, protein dissection, epitope scaffolding, and epitope masking. We also discuss obstacles for immunofocusing like immune imprinting. A thorough understanding, advancement, and application of the methods we outline here will enable the design of high-resolution vaccines that protect against future viral outbreaks. |
| first_indexed | 2024-03-08T14:19:33Z |
| format | Article |
| id | doaj.art-c87d0ee24fa64f10967ba524efa55c56 |
| institution | Directory Open Access Journal |
| issn | 2059-0105 |
| language | English |
| last_indexed | 2024-03-08T14:19:33Z |
| publishDate | 2024-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Vaccines |
| spelling | doaj.art-c87d0ee24fa64f10967ba524efa55c562024-01-14T12:11:08ZengNature Portfolionpj Vaccines2059-01052024-01-019111110.1038/s41541-023-00792-xBringing immunofocusing into focusSriharshita Musunuri0Payton A. B. Weidenbacher1Peter S. Kim2Stanford ChEM-H, Stanford UniversityStanford ChEM-H, Stanford UniversityStanford ChEM-H, Stanford UniversityAbstract Immunofocusing is a strategy to create immunogens that redirect humoral immune responses towards a targeted epitope and away from non-desirable epitopes. Immunofocusing methods often aim to develop “universal” vaccines that provide broad protection against highly variant viruses such as influenza virus, human immunodeficiency virus (HIV-1), and most recently, severe acute respiratory syndrome coronavirus (SARS-CoV-2). We use existing examples to illustrate five main immunofocusing strategies—cross-strain boosting, mosaic display, protein dissection, epitope scaffolding, and epitope masking. We also discuss obstacles for immunofocusing like immune imprinting. A thorough understanding, advancement, and application of the methods we outline here will enable the design of high-resolution vaccines that protect against future viral outbreaks.https://doi.org/10.1038/s41541-023-00792-x |
| spellingShingle | Sriharshita Musunuri Payton A. B. Weidenbacher Peter S. Kim Bringing immunofocusing into focus npj Vaccines |
| title | Bringing immunofocusing into focus |
| title_full | Bringing immunofocusing into focus |
| title_fullStr | Bringing immunofocusing into focus |
| title_full_unstemmed | Bringing immunofocusing into focus |
| title_short | Bringing immunofocusing into focus |
| title_sort | bringing immunofocusing into focus |
| url | https://doi.org/10.1038/s41541-023-00792-x |
| work_keys_str_mv | AT sriharshitamusunuri bringingimmunofocusingintofocus AT paytonabweidenbacher bringingimmunofocusingintofocus AT peterskim bringingimmunofocusingintofocus |