A Markerless CRISPR-Mediated System for Genome Editing in Candida auris Reveals a Conserved Role for Cas5 in the Caspofungin Response

A Markerless CRISPR-Mediated System for Genome Editing in Candida auris Reveals a Conserved Role for Cas5 in the Caspofungin Response

ABSTRACT Candida auris is a multidrug-resistant human fungal pathogen that has recently emerged worldwide. It can cause life-threatening disseminated infections in humans, with mortality rates upwards of 50%. The molecular mechanisms underlying its multidrug resistance and pathogenic properties are...

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Bibliographic Details
Main Authors: Craig L. Ennis, Aaron D. Hernday, Clarissa J. Nobile
Format: Article
Language:English
Published: American Society for Microbiology 2021-12-01
Series:Microbiology Spectrum
Subjects:
CRISPR
Candida auris
Cas5
Cas9
caspofungin
drug resistance mechanisms
Online Access:https://journals.asm.org/doi/10.1128/Spectrum.01820-21

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