Amelioration of Obesity-Related Disorders in High-Fat Diet-Fed Mice following Fecal Microbiota Transplantation from Inulin-Dosed Mice
The role of inulin in alleviating obesity-related disorders has been documented; yet, its underlying mechanisms still need to be further investigated. This study attempted to elucidate the causative link between the gut microbiota and the beneficial effect of inulin on obesity-related disorders via...
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MDPI AG
2023-05-01
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| Online Access: | https://www.mdpi.com/1420-3049/28/10/3997 |
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| author | Yinli Huang Na Ying Qihui Zhao Junli Chen Sin-Yeang Teow Wei Dong Minjie Lin Lingling Jiang Hong Zheng |
| author_facet | Yinli Huang Na Ying Qihui Zhao Junli Chen Sin-Yeang Teow Wei Dong Minjie Lin Lingling Jiang Hong Zheng |
| author_sort | Yinli Huang |
| collection | DOAJ |
| description | The role of inulin in alleviating obesity-related disorders has been documented; yet, its underlying mechanisms still need to be further investigated. This study attempted to elucidate the causative link between the gut microbiota and the beneficial effect of inulin on obesity-related disorders via transferring the fecal microbiota from inulin-dosed mice to high-fat diet (HFD)-induced obese recipient mice. The results show that inulin supplementation can decrease body weight, fat accumulation, and systemic inflammation and can also enhance glucose metabolism in HFD-induced obese mice. Treatment with inulin reshaped the structure and composition of the gut microbiota in HFD-induced obese mice, as characterized by increases in the relative abundances of <i>Bifidobacterium</i> and <i>Muribaculum</i> and decreases in <i>unidentified_Lachnospiraceae</i> and <i>Lachnoclostridium</i>. In addition, we found that these favorable effects of inulin could be partially transferable by fecal microbiota transplantation, and <i>Bifidobacterium</i> and <i>Muribaculum</i> might be the key bacterial genera. Therefore, our results suggest that inulin ameliorates obesity-related disorders by targeting the gut microbiota. |
| first_indexed | 2024-03-11T03:27:44Z |
| format | Article |
| id | doaj.art-c87dba6bc3704cd4b3f4cf9b0fdbd499 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T03:27:44Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
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| series | Molecules |
| spelling | doaj.art-c87dba6bc3704cd4b3f4cf9b0fdbd4992023-11-18T02:37:48ZengMDPI AGMolecules1420-30492023-05-012810399710.3390/molecules28103997Amelioration of Obesity-Related Disorders in High-Fat Diet-Fed Mice following Fecal Microbiota Transplantation from Inulin-Dosed MiceYinli Huang0Na Ying1Qihui Zhao2Junli Chen3Sin-Yeang Teow4Wei Dong5Minjie Lin6Lingling Jiang7Hong Zheng8Department of Endocrinology, Pingyang Affiliated Hospital of Wenzhou Medical University, Wenzhou 325400, ChinaSchool of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, ChinaSchool of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, ChinaSchool of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, ChinaCollege of Science and Technology, Wenzhou-Kean University, Wenzhou 325060, ChinaDepartment of Endocrinology, Pingyang Affiliated Hospital of Wenzhou Medical University, Wenzhou 325400, ChinaDepartment of Endocrinology, Pingyang Affiliated Hospital of Wenzhou Medical University, Wenzhou 325400, ChinaCollege of Science and Technology, Wenzhou-Kean University, Wenzhou 325060, ChinaDepartment of Endocrinology, Pingyang Affiliated Hospital of Wenzhou Medical University, Wenzhou 325400, ChinaThe role of inulin in alleviating obesity-related disorders has been documented; yet, its underlying mechanisms still need to be further investigated. This study attempted to elucidate the causative link between the gut microbiota and the beneficial effect of inulin on obesity-related disorders via transferring the fecal microbiota from inulin-dosed mice to high-fat diet (HFD)-induced obese recipient mice. The results show that inulin supplementation can decrease body weight, fat accumulation, and systemic inflammation and can also enhance glucose metabolism in HFD-induced obese mice. Treatment with inulin reshaped the structure and composition of the gut microbiota in HFD-induced obese mice, as characterized by increases in the relative abundances of <i>Bifidobacterium</i> and <i>Muribaculum</i> and decreases in <i>unidentified_Lachnospiraceae</i> and <i>Lachnoclostridium</i>. In addition, we found that these favorable effects of inulin could be partially transferable by fecal microbiota transplantation, and <i>Bifidobacterium</i> and <i>Muribaculum</i> might be the key bacterial genera. Therefore, our results suggest that inulin ameliorates obesity-related disorders by targeting the gut microbiota.https://www.mdpi.com/1420-3049/28/10/3997obesityinulingut microbiotainflammationliver |
| spellingShingle | Yinli Huang Na Ying Qihui Zhao Junli Chen Sin-Yeang Teow Wei Dong Minjie Lin Lingling Jiang Hong Zheng Amelioration of Obesity-Related Disorders in High-Fat Diet-Fed Mice following Fecal Microbiota Transplantation from Inulin-Dosed Mice Molecules obesity inulin gut microbiota inflammation liver |
| title | Amelioration of Obesity-Related Disorders in High-Fat Diet-Fed Mice following Fecal Microbiota Transplantation from Inulin-Dosed Mice |
| title_full | Amelioration of Obesity-Related Disorders in High-Fat Diet-Fed Mice following Fecal Microbiota Transplantation from Inulin-Dosed Mice |
| title_fullStr | Amelioration of Obesity-Related Disorders in High-Fat Diet-Fed Mice following Fecal Microbiota Transplantation from Inulin-Dosed Mice |
| title_full_unstemmed | Amelioration of Obesity-Related Disorders in High-Fat Diet-Fed Mice following Fecal Microbiota Transplantation from Inulin-Dosed Mice |
| title_short | Amelioration of Obesity-Related Disorders in High-Fat Diet-Fed Mice following Fecal Microbiota Transplantation from Inulin-Dosed Mice |
| title_sort | amelioration of obesity related disorders in high fat diet fed mice following fecal microbiota transplantation from inulin dosed mice |
| topic | obesity inulin gut microbiota inflammation liver |
| url | https://www.mdpi.com/1420-3049/28/10/3997 |
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