Diffusion and Controlled Release in Physically Crosslinked Poly (Vinyl Alcohol)/Iota-Carrageenan Hydrogel Blends
This paper reports the obtaining of poly (vinyl alcohol) and ι-carrageenan blend hydrogels by physical crosslinking (consecutive freeze–thaw cycles). The two polymers were completely miscible in the weight ratio interval used in this study, as determined by solution viscometry data. Strong interacti...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-07-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/12/7/1544 |
| _version_ | 1797562560784891904 |
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| author | Catalin Croitoru Ionut Claudiu Roata Alexandru Pascu Elena Manuela Stanciu |
| author_facet | Catalin Croitoru Ionut Claudiu Roata Alexandru Pascu Elena Manuela Stanciu |
| author_sort | Catalin Croitoru |
| collection | DOAJ |
| description | This paper reports the obtaining of poly (vinyl alcohol) and ι-carrageenan blend hydrogels by physical crosslinking (consecutive freeze–thaw cycles). The two polymers were completely miscible in the weight ratio interval used in this study, as determined by solution viscometry data. Strong interactions through hydrogen bonding and forming of mixed interpolymer crystalline domains were observed, which are responsible for the formation of stable drug release-tunable matrices. The release profiles of three model antibiotic drugs (amoxicillin, tetracycline hydrochloride, and gentamicin sulfate) were assessed in a pH interval between 3 and 7.3. They were found to be strongly dependent on the drug chemistry, mesh size of the hydrogels, swelling mechanism, and pH of the release medium. A decrease of up to 40% in the release rates and up to 10% in the diffusion coefficients of the model drugs was registered with the increase in ι-carrageenan content. |
| first_indexed | 2024-03-10T18:30:57Z |
| format | Article |
| id | doaj.art-c87ecb6642404ec89743ad651bfa190d |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-10T18:30:57Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-c87ecb6642404ec89743ad651bfa190d2023-11-20T06:38:17ZengMDPI AGPolymers2073-43602020-07-01127154410.3390/polym12071544Diffusion and Controlled Release in Physically Crosslinked Poly (Vinyl Alcohol)/Iota-Carrageenan Hydrogel BlendsCatalin Croitoru0Ionut Claudiu Roata1Alexandru Pascu2Elena Manuela Stanciu3Materials Engineering and Welding Department, Transilvania University of Brasov, Eroilor 29 Str, 500036 Brasov, RomaniaMaterials Engineering and Welding Department, Transilvania University of Brasov, Eroilor 29 Str, 500036 Brasov, RomaniaMaterials Engineering and Welding Department, Transilvania University of Brasov, Eroilor 29 Str, 500036 Brasov, RomaniaMaterials Engineering and Welding Department, Transilvania University of Brasov, Eroilor 29 Str, 500036 Brasov, RomaniaThis paper reports the obtaining of poly (vinyl alcohol) and ι-carrageenan blend hydrogels by physical crosslinking (consecutive freeze–thaw cycles). The two polymers were completely miscible in the weight ratio interval used in this study, as determined by solution viscometry data. Strong interactions through hydrogen bonding and forming of mixed interpolymer crystalline domains were observed, which are responsible for the formation of stable drug release-tunable matrices. The release profiles of three model antibiotic drugs (amoxicillin, tetracycline hydrochloride, and gentamicin sulfate) were assessed in a pH interval between 3 and 7.3. They were found to be strongly dependent on the drug chemistry, mesh size of the hydrogels, swelling mechanism, and pH of the release medium. A decrease of up to 40% in the release rates and up to 10% in the diffusion coefficients of the model drugs was registered with the increase in ι-carrageenan content.https://www.mdpi.com/2073-4360/12/7/1544poly (vinyl alcohol)iota-carrageenanpolymer blendspolysaccharidehydrogelsswelling |
| spellingShingle | Catalin Croitoru Ionut Claudiu Roata Alexandru Pascu Elena Manuela Stanciu Diffusion and Controlled Release in Physically Crosslinked Poly (Vinyl Alcohol)/Iota-Carrageenan Hydrogel Blends Polymers poly (vinyl alcohol) iota-carrageenan polymer blends polysaccharide hydrogels swelling |
| title | Diffusion and Controlled Release in Physically Crosslinked Poly (Vinyl Alcohol)/Iota-Carrageenan Hydrogel Blends |
| title_full | Diffusion and Controlled Release in Physically Crosslinked Poly (Vinyl Alcohol)/Iota-Carrageenan Hydrogel Blends |
| title_fullStr | Diffusion and Controlled Release in Physically Crosslinked Poly (Vinyl Alcohol)/Iota-Carrageenan Hydrogel Blends |
| title_full_unstemmed | Diffusion and Controlled Release in Physically Crosslinked Poly (Vinyl Alcohol)/Iota-Carrageenan Hydrogel Blends |
| title_short | Diffusion and Controlled Release in Physically Crosslinked Poly (Vinyl Alcohol)/Iota-Carrageenan Hydrogel Blends |
| title_sort | diffusion and controlled release in physically crosslinked poly vinyl alcohol iota carrageenan hydrogel blends |
| topic | poly (vinyl alcohol) iota-carrageenan polymer blends polysaccharide hydrogels swelling |
| url | https://www.mdpi.com/2073-4360/12/7/1544 |
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