THE EFFECT OF PRAZOSIN ON COMBAT RELATED POSTTRAUMATIC STRESS DISORDER NIGHTMARES
Introduction: Several studies have shown noradrenergic system hyperactivity in posttraumatic stress disorder. Four Vietnam combat veterans with chronic PTSD, prescribed prazosin ?1 adrenergic receptor antagonist reported reduction or completely elimination of combat trauma nightmares. This study pro...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2003-12-01
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| Series: | Journal of Research in Medical Sciences |
| Subjects: | |
| Online Access: | http://journals.mui.ac.ir/jrms/article/view/2891 |
| _version_ | 1818789218794602496 |
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| author | G ASSADOUAHI GH AHMADZADEH J MAHMOUDI GHARAEI N BASHARDOOST T FAGHIHI |
| author_facet | G ASSADOUAHI GH AHMADZADEH J MAHMOUDI GHARAEI N BASHARDOOST T FAGHIHI |
| author_sort | G ASSADOUAHI |
| collection | DOAJ |
| description | Introduction: Several studies have shown noradrenergic system hyperactivity in posttraumatic stress disorder. Four Vietnam combat veterans with chronic PTSD, prescribed prazosin ?1 adrenergic receptor antagonist reported reduction or completely elimination of combat trauma nightmares. This study prompted an open trial of prazosin for Iran & Iraq combat PTSD patients nightmares. Method: Twenty two male and married patients with chronic DSM N PTSD and combat trauma related nightmares participated in an 8-week Before - After open trial. The exclusion criteria included current substance abuse or dependency, psychotic disorders and any medical condition that contraindicated the use of prazosin. Results: Six patients were withdrown from the study because of Prazosin side effects. In reminders average of nightmare severity reduced from 6.75 to 3.56 which was statistically significant (p<0.001). Dicussion & Conclusion: The association between prazosin administration and reduction of PTSD nightmare severity suggested possible efficacy of ?1- adrenergic recptor blockade for this PTSD symptom. |
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| id | doaj.art-c87ef7b4f84c4037be3b5214c50515cb |
| institution | Directory Open Access Journal |
| issn | 1735-1995 1735-7136 |
| language | English |
| last_indexed | 2024-12-18T14:36:04Z |
| publishDate | 2003-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
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| series | Journal of Research in Medical Sciences |
| spelling | doaj.art-c87ef7b4f84c4037be3b5214c50515cb2022-12-21T21:04:30ZengWolters Kluwer Medknow PublicationsJournal of Research in Medical Sciences1735-19951735-71362003-12-0184THE EFFECT OF PRAZOSIN ON COMBAT RELATED POSTTRAUMATIC STRESS DISORDER NIGHTMARESG ASSADOUAHIGH AHMADZADEHJ MAHMOUDI GHARAEIN BASHARDOOSTT FAGHIHIIntroduction: Several studies have shown noradrenergic system hyperactivity in posttraumatic stress disorder. Four Vietnam combat veterans with chronic PTSD, prescribed prazosin ?1 adrenergic receptor antagonist reported reduction or completely elimination of combat trauma nightmares. This study prompted an open trial of prazosin for Iran & Iraq combat PTSD patients nightmares. Method: Twenty two male and married patients with chronic DSM N PTSD and combat trauma related nightmares participated in an 8-week Before - After open trial. The exclusion criteria included current substance abuse or dependency, psychotic disorders and any medical condition that contraindicated the use of prazosin. Results: Six patients were withdrown from the study because of Prazosin side effects. In reminders average of nightmare severity reduced from 6.75 to 3.56 which was statistically significant (p<0.001). Dicussion & Conclusion: The association between prazosin administration and reduction of PTSD nightmare severity suggested possible efficacy of ?1- adrenergic recptor blockade for this PTSD symptom.http://journals.mui.ac.ir/jrms/article/view/2891Posttraumatic Stress Disorder - Nightmare - Prazosin- ?1 - adrenergic receptor antagonist |
| spellingShingle | G ASSADOUAHI GH AHMADZADEH J MAHMOUDI GHARAEI N BASHARDOOST T FAGHIHI THE EFFECT OF PRAZOSIN ON COMBAT RELATED POSTTRAUMATIC STRESS DISORDER NIGHTMARES Journal of Research in Medical Sciences Posttraumatic Stress Disorder - Nightmare - Prazosin- ?1 - adrenergic receptor antagonist |
| title | THE EFFECT OF PRAZOSIN ON COMBAT RELATED POSTTRAUMATIC STRESS DISORDER NIGHTMARES |
| title_full | THE EFFECT OF PRAZOSIN ON COMBAT RELATED POSTTRAUMATIC STRESS DISORDER NIGHTMARES |
| title_fullStr | THE EFFECT OF PRAZOSIN ON COMBAT RELATED POSTTRAUMATIC STRESS DISORDER NIGHTMARES |
| title_full_unstemmed | THE EFFECT OF PRAZOSIN ON COMBAT RELATED POSTTRAUMATIC STRESS DISORDER NIGHTMARES |
| title_short | THE EFFECT OF PRAZOSIN ON COMBAT RELATED POSTTRAUMATIC STRESS DISORDER NIGHTMARES |
| title_sort | effect of prazosin on combat related posttraumatic stress disorder nightmares |
| topic | Posttraumatic Stress Disorder - Nightmare - Prazosin- ?1 - adrenergic receptor antagonist |
| url | http://journals.mui.ac.ir/jrms/article/view/2891 |
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