Frequent alterations in p16/CDKN2A identified by immunohistochemistry and FISH in chordoma

Frequent alterations in p16/CDKN2A identified by immunohistochemistry and FISH in chordoma

Abstract The expression of p16/CDKN2A, the second most commonly inactivated tumour suppressor gene in cancer, is lost in the majority of chordomas. However, the mechanism(s) leading to its inactivation and contribution to disease progression have only been partially addressed using small patient coh...

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Bibliographic Details
Main Authors: Lucia Cottone, Nadia Eden, Inga Usher, Patrick Lombard, Hongtao Ye, Lorena Ligammari, Daniel Lindsay, Sebastian Brandner, Jože Pižem, Nischalan Pillay, Roberto Tirabosco, Fernanda Amary, Adrienne M Flanagan
Format: Article
Language:English
Published: Wiley 2020-04-01
Series:The Journal of Pathology: Clinical Research
Subjects:
chordoma
copy number
p16
CDKN2A
IHC
FISH
Online Access:https://doi.org/10.1002/cjp2.156

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