Remarkable response to third-generation EGFR-TKI plus crizotinib in a patient with pulmonary adenocarcinoma harboring EGFR and ROS1 co-mutation: a case report

Remarkable response to third-generation EGFR-TKI plus crizotinib in a patient with pulmonary adenocarcinoma harboring EGFR and ROS1 co-mutation: a case report

BackgroundDriver oncogene mutations, such as c-ros oncogene 1 (ROS1) and epidermal growth factor receptor (EGFR) were previously believed to be mutually exclusive in non-small cell lung cancer (NSCLC). Only sporadic cases of ROS1 and EGFR co-mutations have been reported. Hence, appropriate treatment...

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Bibliographic Details
Main Authors:	Zhiming Wu, Zelin Zhang, Dongdong Zhang, Zengyan Li
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-02-01
Series:	Frontiers in Oncology
Subjects:	non-small cell lung cancer EGFR ROS1 tyrosine kinase inhibitors co-mutation
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2024.1357230/full

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