Composition of the bacterial community in the gastrointestinal tract of Kunming mice
Background: The intestinal bacterial community has an important role in maintaining human health. Dysbiosis is a key inducer of many chronic diseases including obesity and diabetes. Kunming mice are frequently used as a model of human disease and yet little is known about the bacterial microbiome re...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-01-01
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| Series: | Electronic Journal of Biotechnology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0717345819300508 |
| _version_ | 1828239252419248128 |
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| author | Xufeng Han Haiyan Shao Yi Wang Ankang Hu Renjin Chen Quangang Chen |
| author_facet | Xufeng Han Haiyan Shao Yi Wang Ankang Hu Renjin Chen Quangang Chen |
| author_sort | Xufeng Han |
| collection | DOAJ |
| description | Background: The intestinal bacterial community has an important role in maintaining human health. Dysbiosis is a key inducer of many chronic diseases including obesity and diabetes. Kunming mice are frequently used as a model of human disease and yet little is known about the bacterial microbiome resident to the gastrointestinal tract. Results: We undertook metagenomic sequencing of the luminal contents of the stomach, duodenum, jejunum, ileum, cecum, colon, and rectum of Kunming mice. Firmicutes was the dominant bacterial phylum of each intestinal tract and Lactobacillus the dominant genus. However, the bacterial composition differed among the seven intestinal tracts of Kunming mice. Compared with the small intestine, the large intestine bacterial community of Kunming mice is more stable and diverse. Conclusions: To our knowledge, ours is the first study to systematically describe the gastrointestinal bacterial composition of Kunming mice. Our findings provide a better understanding of the bacterial composition of Kunming mice and serves as a foundation for the study of precision medicine.How to cite: Han X, Shao H, Wang Y, et al. Composition of the bacterial community in the gastrointestinal tract of Kunming mice. Electron J Biotechnol 2020;43. https://doi.org/10.1016/j.ejbt.2019.11.003 Keywords: 16S rRNA, Bacterial community, Firmicutes, Gastrointestinal tract, Gut ecology, High-throughput sequencing, Intestinal bacterial, Kunming mice, Lactobacillus, Metageno mic sequencing, Microbiome |
| first_indexed | 2024-04-12T21:19:38Z |
| format | Article |
| id | doaj.art-c883ab4c48db46c18fa5ef96962ebaeb |
| institution | Directory Open Access Journal |
| issn | 0717-3458 |
| language | English |
| last_indexed | 2024-04-12T21:19:38Z |
| publishDate | 2020-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Electronic Journal of Biotechnology |
| spelling | doaj.art-c883ab4c48db46c18fa5ef96962ebaeb2022-12-22T03:16:21ZengElsevierElectronic Journal of Biotechnology0717-34582020-01-01431622Composition of the bacterial community in the gastrointestinal tract of Kunming miceXufeng Han0Haiyan Shao1Yi Wang2Ankang Hu3Renjin Chen4Quangang Chen5Laboratory Animal Center, Xuzhou Medical University, Xuzhou, Jiangsu, PR ChinaPsychological Counseling and Treatment Center, Xuzhou Oriental People's Hospital, Xuzhou, Jiangsu, PR ChinaLaboratory Animal Center, Xuzhou Medical University, Xuzhou, Jiangsu, PR ChinaLaboratory Animal Center, Xuzhou Medical University, Xuzhou, Jiangsu, PR ChinaLaboratory Animal Center, Xuzhou Medical University, Xuzhou, Jiangsu, PR ChinaLaboratory Animal Center, Xuzhou Medical University, Xuzhou, Jiangsu, PR China; Corresponding author.Background: The intestinal bacterial community has an important role in maintaining human health. Dysbiosis is a key inducer of many chronic diseases including obesity and diabetes. Kunming mice are frequently used as a model of human disease and yet little is known about the bacterial microbiome resident to the gastrointestinal tract. Results: We undertook metagenomic sequencing of the luminal contents of the stomach, duodenum, jejunum, ileum, cecum, colon, and rectum of Kunming mice. Firmicutes was the dominant bacterial phylum of each intestinal tract and Lactobacillus the dominant genus. However, the bacterial composition differed among the seven intestinal tracts of Kunming mice. Compared with the small intestine, the large intestine bacterial community of Kunming mice is more stable and diverse. Conclusions: To our knowledge, ours is the first study to systematically describe the gastrointestinal bacterial composition of Kunming mice. Our findings provide a better understanding of the bacterial composition of Kunming mice and serves as a foundation for the study of precision medicine.How to cite: Han X, Shao H, Wang Y, et al. Composition of the bacterial community in the gastrointestinal tract of Kunming mice. Electron J Biotechnol 2020;43. https://doi.org/10.1016/j.ejbt.2019.11.003 Keywords: 16S rRNA, Bacterial community, Firmicutes, Gastrointestinal tract, Gut ecology, High-throughput sequencing, Intestinal bacterial, Kunming mice, Lactobacillus, Metageno mic sequencing, Microbiomehttp://www.sciencedirect.com/science/article/pii/S0717345819300508 |
| spellingShingle | Xufeng Han Haiyan Shao Yi Wang Ankang Hu Renjin Chen Quangang Chen Composition of the bacterial community in the gastrointestinal tract of Kunming mice Electronic Journal of Biotechnology |
| title | Composition of the bacterial community in the gastrointestinal tract of Kunming mice |
| title_full | Composition of the bacterial community in the gastrointestinal tract of Kunming mice |
| title_fullStr | Composition of the bacterial community in the gastrointestinal tract of Kunming mice |
| title_full_unstemmed | Composition of the bacterial community in the gastrointestinal tract of Kunming mice |
| title_short | Composition of the bacterial community in the gastrointestinal tract of Kunming mice |
| title_sort | composition of the bacterial community in the gastrointestinal tract of kunming mice |
| url | http://www.sciencedirect.com/science/article/pii/S0717345819300508 |
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