A Scoping Review of Mathematical Models Used to Investigate the Role of Dogs in Chagas Disease Transmission
Chagas disease is a zoonotic vector-borne disease caused by the parasite <i>Trypanosoma cruzi</i>, which affects a variety of mammalian species across the Americas, including humans and dogs. Mathematical modeling has been widely used to investigate the transmission dynamics and control...
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MDPI AG
2023-02-01
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| Series: | Animals |
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| Online Access: | https://www.mdpi.com/2076-2615/13/4/555 |
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| author | Edem Fiatsonu Rachel E. Busselman Martial L. Ndeffo-Mbah |
| author_facet | Edem Fiatsonu Rachel E. Busselman Martial L. Ndeffo-Mbah |
| author_sort | Edem Fiatsonu |
| collection | DOAJ |
| description | Chagas disease is a zoonotic vector-borne disease caused by the parasite <i>Trypanosoma cruzi</i>, which affects a variety of mammalian species across the Americas, including humans and dogs. Mathematical modeling has been widely used to investigate the transmission dynamics and control of vector-borne diseases. We performed a scoping review of mathematical models that investigated the role of dogs in <i>T. cruzi</i> transmission. We identified ten peer-reviewed papers that have explicitly modeled the role of dogs in Chagas transmission dynamics. We discuss the different methods employed in these studies, the different transmission metrics, disease transmission routes, and disease control strategies that have been considered and evaluated. In general, mathematical modeling studies have shown that dogs are not only at high risk of <i>T. cruzi</i> infection but are also major contributors to <i>T. cruzi</i> transmission to humans. Moreover, eliminating infected dogs from households or frequent use of insecticide was shown to be effective for curtailing <i>T. cruzi</i> transmission in both humans and dogs. However, when insecticide spraying is discontinued, <i>T. cruzi</i> infections in dogs were shown to return to their pre-spraying levels. We discuss the challenges and opportunities for future modeling studies to improve our understanding of Chagas disease transmission dynamics and control. |
| first_indexed | 2024-03-11T09:16:20Z |
| format | Article |
| id | doaj.art-c8845c5828e54c52bc75c9e80de4d7f4 |
| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-11T09:16:20Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj.art-c8845c5828e54c52bc75c9e80de4d7f42023-11-16T18:38:13ZengMDPI AGAnimals2076-26152023-02-0113455510.3390/ani13040555A Scoping Review of Mathematical Models Used to Investigate the Role of Dogs in Chagas Disease TransmissionEdem Fiatsonu0Rachel E. Busselman1Martial L. Ndeffo-Mbah2Department of Veterinary Integrative Biosciences, School of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843, USADepartment of Veterinary Integrative Biosciences, School of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843, USADepartment of Veterinary Integrative Biosciences, School of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843, USAChagas disease is a zoonotic vector-borne disease caused by the parasite <i>Trypanosoma cruzi</i>, which affects a variety of mammalian species across the Americas, including humans and dogs. Mathematical modeling has been widely used to investigate the transmission dynamics and control of vector-borne diseases. We performed a scoping review of mathematical models that investigated the role of dogs in <i>T. cruzi</i> transmission. We identified ten peer-reviewed papers that have explicitly modeled the role of dogs in Chagas transmission dynamics. We discuss the different methods employed in these studies, the different transmission metrics, disease transmission routes, and disease control strategies that have been considered and evaluated. In general, mathematical modeling studies have shown that dogs are not only at high risk of <i>T. cruzi</i> infection but are also major contributors to <i>T. cruzi</i> transmission to humans. Moreover, eliminating infected dogs from households or frequent use of insecticide was shown to be effective for curtailing <i>T. cruzi</i> transmission in both humans and dogs. However, when insecticide spraying is discontinued, <i>T. cruzi</i> infections in dogs were shown to return to their pre-spraying levels. We discuss the challenges and opportunities for future modeling studies to improve our understanding of Chagas disease transmission dynamics and control.https://www.mdpi.com/2076-2615/13/4/555Canine Chagas diseasedynamic transmission model<i>Trypanosoma cruzi</i> |
| spellingShingle | Edem Fiatsonu Rachel E. Busselman Martial L. Ndeffo-Mbah A Scoping Review of Mathematical Models Used to Investigate the Role of Dogs in Chagas Disease Transmission Animals Canine Chagas disease dynamic transmission model <i>Trypanosoma cruzi</i> |
| title | A Scoping Review of Mathematical Models Used to Investigate the Role of Dogs in Chagas Disease Transmission |
| title_full | A Scoping Review of Mathematical Models Used to Investigate the Role of Dogs in Chagas Disease Transmission |
| title_fullStr | A Scoping Review of Mathematical Models Used to Investigate the Role of Dogs in Chagas Disease Transmission |
| title_full_unstemmed | A Scoping Review of Mathematical Models Used to Investigate the Role of Dogs in Chagas Disease Transmission |
| title_short | A Scoping Review of Mathematical Models Used to Investigate the Role of Dogs in Chagas Disease Transmission |
| title_sort | scoping review of mathematical models used to investigate the role of dogs in chagas disease transmission |
| topic | Canine Chagas disease dynamic transmission model <i>Trypanosoma cruzi</i> |
| url | https://www.mdpi.com/2076-2615/13/4/555 |
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