Reduced Plasma Kallistatin Is Associated With the Severity of Coronary Artery Disease, and Kallistatin Treatment Attenuates Atherosclerotic Plaque Formation in Mice

Reduced Plasma Kallistatin Is Associated With the Severity of Coronary Artery Disease, and Kallistatin Treatment Attenuates Atherosclerotic Plaque Formation in Mice

Background Kallistatin exerts beneficial effects on organ injury by inhibiting oxidative stress and inflammation. However, the role of kallistatin in atherosclerosis is largely unknown. Here, we investigated the role and mechanisms of kallistatin in patients with coronary artery disease (CAD), ather...

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Bibliographic Details
Main Authors: Yuyu Yao, Bing Li, Chang Liu, Cong Fu, Pengfei Li, Youming Guo, Genshan Ma, Naifeng Liu, Lee Chao, Julie Chao
Format: Article
Language:English
Published: Wiley 2018-11-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
atherosclerosis
coronary artery disease
kallistatin
oxidative stress
sirtuin 1
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.118.009562

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