Insights into the Conserved Regulatory Mechanisms of Human and Yeast Aging
Aging represents a significant biological process having strong associations with cancer, diabetes, and neurodegenerative and cardiovascular disorders, which leads to progressive loss of cellular functions and viability. Astonishingly, age-related disorders share several genetic and molecular mechan...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-06-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/10/6/882 |
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| author | Rashmi Dahiya Taj Mohammad Mohamed F. Alajmi Md. Tabish Rehman Gulam Mustafa Hasan Afzal Hussain Md. Imtaiyaz Hassan |
| author_facet | Rashmi Dahiya Taj Mohammad Mohamed F. Alajmi Md. Tabish Rehman Gulam Mustafa Hasan Afzal Hussain Md. Imtaiyaz Hassan |
| author_sort | Rashmi Dahiya |
| collection | DOAJ |
| description | Aging represents a significant biological process having strong associations with cancer, diabetes, and neurodegenerative and cardiovascular disorders, which leads to progressive loss of cellular functions and viability. Astonishingly, age-related disorders share several genetic and molecular mechanisms with the normal aging process. Over the last three decades, budding yeast <i>Saccharomyces cerevisiae</i> has emerged as a powerful yet simple model organism for aging research. Genetic approaches using yeast RLS have led to the identification of hundreds of genes impacting lifespan in higher eukaryotes. Numerous interventions to extend yeast lifespan showed an analogous outcome in multi-cellular eukaryotes like fruit flies, nematodes, rodents, and humans. We collected and analyzed a multitude of observations from published literature and provide the contribution of yeast in the understanding of aging hallmarks most applicable to humans. Here, we discuss key pathways and molecular mechanisms that underpin the evolutionarily conserved aging process and summarize the current understanding and clinical applicability of its trajectories. Gathering critical information on aging biology would pave the way for future investigation targeted at the discovery of aging interventions. |
| first_indexed | 2024-03-10T19:18:17Z |
| format | Article |
| id | doaj.art-c88533db078a4acab7204bc7e28f9c9e |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T19:18:17Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-c88533db078a4acab7204bc7e28f9c9e2023-11-20T03:15:16ZengMDPI AGBiomolecules2218-273X2020-06-0110688210.3390/biom10060882Insights into the Conserved Regulatory Mechanisms of Human and Yeast AgingRashmi Dahiya0Taj Mohammad1Mohamed F. Alajmi2Md. Tabish Rehman3Gulam Mustafa Hasan4Afzal Hussain5Md. Imtaiyaz Hassan6Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi 110025, IndiaCentre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi 110025, IndiaDepartment of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Biochemistry, College of Medicine, Prince Sattam Bin Abdulaziz University, P.O. Box 173, Al-Kharj 11942, Saudi ArabiaDepartment of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi ArabiaCentre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi 110025, IndiaAging represents a significant biological process having strong associations with cancer, diabetes, and neurodegenerative and cardiovascular disorders, which leads to progressive loss of cellular functions and viability. Astonishingly, age-related disorders share several genetic and molecular mechanisms with the normal aging process. Over the last three decades, budding yeast <i>Saccharomyces cerevisiae</i> has emerged as a powerful yet simple model organism for aging research. Genetic approaches using yeast RLS have led to the identification of hundreds of genes impacting lifespan in higher eukaryotes. Numerous interventions to extend yeast lifespan showed an analogous outcome in multi-cellular eukaryotes like fruit flies, nematodes, rodents, and humans. We collected and analyzed a multitude of observations from published literature and provide the contribution of yeast in the understanding of aging hallmarks most applicable to humans. Here, we discuss key pathways and molecular mechanisms that underpin the evolutionarily conserved aging process and summarize the current understanding and clinical applicability of its trajectories. Gathering critical information on aging biology would pave the way for future investigation targeted at the discovery of aging interventions.https://www.mdpi.com/2218-273X/10/6/882agingevolutionary conservationsbudding yeastlongevitygenomic instabilitycalorie restriction |
| spellingShingle | Rashmi Dahiya Taj Mohammad Mohamed F. Alajmi Md. Tabish Rehman Gulam Mustafa Hasan Afzal Hussain Md. Imtaiyaz Hassan Insights into the Conserved Regulatory Mechanisms of Human and Yeast Aging Biomolecules aging evolutionary conservations budding yeast longevity genomic instability calorie restriction |
| title | Insights into the Conserved Regulatory Mechanisms of Human and Yeast Aging |
| title_full | Insights into the Conserved Regulatory Mechanisms of Human and Yeast Aging |
| title_fullStr | Insights into the Conserved Regulatory Mechanisms of Human and Yeast Aging |
| title_full_unstemmed | Insights into the Conserved Regulatory Mechanisms of Human and Yeast Aging |
| title_short | Insights into the Conserved Regulatory Mechanisms of Human and Yeast Aging |
| title_sort | insights into the conserved regulatory mechanisms of human and yeast aging |
| topic | aging evolutionary conservations budding yeast longevity genomic instability calorie restriction |
| url | https://www.mdpi.com/2218-273X/10/6/882 |
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