Glycemic Control with Thiazolidinedione Is Associated with Fracture of T2DM Patients.
Diabetes is a common diseases and a major problem worldwide. Diabetic osteopathy might be elevated in diabetic patients and is usually caused by bone fracture. Several diabetes medications, such as thiazolidinediones (TZDs), could lead to increased risks of fracture.We used the nationwide database t...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4552881?pdf=render |
| _version_ | 1818515382963535872 |
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| author | Hsin-Hung Chen Ming-Hwarng Horng Su-Yin Yeh I-Ching Lin Chih-Jung Yeh Chih-Hsin Muo Fung-Chang Sung Chia-Hung Kao |
| author_facet | Hsin-Hung Chen Ming-Hwarng Horng Su-Yin Yeh I-Ching Lin Chih-Jung Yeh Chih-Hsin Muo Fung-Chang Sung Chia-Hung Kao |
| author_sort | Hsin-Hung Chen |
| collection | DOAJ |
| description | Diabetes is a common diseases and a major problem worldwide. Diabetic osteopathy might be elevated in diabetic patients and is usually caused by bone fracture. Several diabetes medications, such as thiazolidinediones (TZDs), could lead to increased risks of fracture.We used the nationwide database to identified 32466 patients who had developed type 2 diabetes from 2000 to 2010 as the diabetic cohort and, from that group, we selected 3427 diabetic patients who had developed bone fracture to survey the possible risk factors, includng commonly used diabetes medication.We found that TZDs might present increased risks for fracture in patients who used it for an extended period (7 to 730 days before the index date), especially in female patients younger than 64 years old, for whom the risk was elevated from a 1.74- to a 2.58-fold odds ratio.We recommend that clinics follow up with non-osteoporotic female patients younger than 64 years old who are using TZDs, to avoid the associated risks of fracture. |
| first_indexed | 2024-12-11T00:28:11Z |
| format | Article |
| id | doaj.art-c8858f96828b49429a69b289afd5406a |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-11T00:28:11Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-c8858f96828b49429a69b289afd5406a2022-12-22T01:27:29ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01108e013553010.1371/journal.pone.0135530Glycemic Control with Thiazolidinedione Is Associated with Fracture of T2DM Patients.Hsin-Hung ChenMing-Hwarng HorngSu-Yin YehI-Ching LinChih-Jung YehChih-Hsin MuoFung-Chang SungChia-Hung KaoDiabetes is a common diseases and a major problem worldwide. Diabetic osteopathy might be elevated in diabetic patients and is usually caused by bone fracture. Several diabetes medications, such as thiazolidinediones (TZDs), could lead to increased risks of fracture.We used the nationwide database to identified 32466 patients who had developed type 2 diabetes from 2000 to 2010 as the diabetic cohort and, from that group, we selected 3427 diabetic patients who had developed bone fracture to survey the possible risk factors, includng commonly used diabetes medication.We found that TZDs might present increased risks for fracture in patients who used it for an extended period (7 to 730 days before the index date), especially in female patients younger than 64 years old, for whom the risk was elevated from a 1.74- to a 2.58-fold odds ratio.We recommend that clinics follow up with non-osteoporotic female patients younger than 64 years old who are using TZDs, to avoid the associated risks of fracture.http://europepmc.org/articles/PMC4552881?pdf=render |
| spellingShingle | Hsin-Hung Chen Ming-Hwarng Horng Su-Yin Yeh I-Ching Lin Chih-Jung Yeh Chih-Hsin Muo Fung-Chang Sung Chia-Hung Kao Glycemic Control with Thiazolidinedione Is Associated with Fracture of T2DM Patients. PLoS ONE |
| title | Glycemic Control with Thiazolidinedione Is Associated with Fracture of T2DM Patients. |
| title_full | Glycemic Control with Thiazolidinedione Is Associated with Fracture of T2DM Patients. |
| title_fullStr | Glycemic Control with Thiazolidinedione Is Associated with Fracture of T2DM Patients. |
| title_full_unstemmed | Glycemic Control with Thiazolidinedione Is Associated with Fracture of T2DM Patients. |
| title_short | Glycemic Control with Thiazolidinedione Is Associated with Fracture of T2DM Patients. |
| title_sort | glycemic control with thiazolidinedione is associated with fracture of t2dm patients |
| url | http://europepmc.org/articles/PMC4552881?pdf=render |
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