Adrenocortical cancer: late diagnosis of the disease on the example of a clinical case. Case report
Adrenocortical carcinoma (ACC) is a rare malignant tumor originating in the adrenal cortex and characterized by poor 5-year survival. It occurs with a frequency of 2–4 cases per 2 million in the population. Women are more frequently affected than men and it is mostly detected in the fourth and fifth...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | Russian |
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"Consilium Medicum" Publishing house
2023-12-01
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| Series: | Терапевтический архив |
| Subjects: | |
| Online Access: | https://ter-arkhiv.ru/0040-3660/article/viewFile/626346/142223 |
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| author | Evgenia A. Starostina Natalya V. Molashenko Anna R. Levshina Nano V. Pachuashvili Anastassia Chevais Mariya P. Isaeva Kantemir V. Getazheev Dmitry G. Beltsevich Nadezhda M. Platonova Ekaterina A. Troshina |
| author_facet | Evgenia A. Starostina Natalya V. Molashenko Anna R. Levshina Nano V. Pachuashvili Anastassia Chevais Mariya P. Isaeva Kantemir V. Getazheev Dmitry G. Beltsevich Nadezhda M. Platonova Ekaterina A. Troshina |
| author_sort | Evgenia A. Starostina |
| collection | DOAJ |
| description | Adrenocortical carcinoma (ACC) is a rare malignant tumor originating in the adrenal cortex and characterized by poor 5-year survival. It occurs with a frequency of 2–4 cases per 2 million in the population. Women are more frequently affected than men and it is mostly detected in the fourth and fifth decades. In the most of cases, the cancerogenesis occurs sporadically because of gene driver mutations in somatic adrenocortical cells, in other cases it can be found as part of a genetically determined syndrome such as Li–Fraumeni syndrome or Wermer's syndrome (multiple endocrine adenomatosis type I). ACC most frequently happens occurs without symptoms in the initial stages leading to poor diagnoses. Because of this lack of early detection, the tumor is not considered malignant reducing the benefits of further treatment. Sometimes the fact that the resected tumor is indeed adrenocortical carcinoma becomes clear only after recurrence, or after the appearance of metastases. We present a case of adrenocortical carcinoma in a 46-year-old woman who went to the doctor in 1.5 year after symptoms were manfested. This clinical case illustrates the consequences of late diagnosis of a malignant tumor. We would like to emphasize the importance of timely detection of a neoplasm, using all of the potential of laboratory-instrumental and genomic analysis. Due to low oncological awareness, our patient was slow to seek medical help, which in turn led not only to metastases, but also to complications in the cardiovascular system. |
| first_indexed | 2024-04-24T23:42:41Z |
| format | Article |
| id | doaj.art-c885fcdbe9ef469fb743920ce9c0b8a6 |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2025-03-21T22:41:43Z |
| publishDate | 2023-12-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-c885fcdbe9ef469fb743920ce9c0b8a62024-05-24T08:42:30Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422023-12-0195121179118410.26442/00403660.2023.12.20243078423Adrenocortical cancer: late diagnosis of the disease on the example of a clinical case. Case reportEvgenia A. Starostina0https://orcid.org/0000-0003-2283-8958Natalya V. Molashenko1https://orcid.org/0000-0001-6265-1210Anna R. Levshina2https://orcid.org/0000-0002-9315-3801Nano V. Pachuashvili3https://orcid.org/0000-0002-8136-0117Anastassia Chevais4https://orcid.org/0000-0001-5592-4794Mariya P. Isaeva5https://orcid.org/0000-0002-9963-6783Kantemir V. Getazheev6https://orcid.org/0000-0001-5193-0556Dmitry G. Beltsevich7https://orcid.org/0000-0001-7098-4584Nadezhda M. Platonova8https://orcid.org/0000-0001-6388-1544Ekaterina A. Troshina9https://orcid.org/0000-0002-8520-8702Endocrinology Research CentreEndocrinology Research CentreSechenov First Moscow State Medical University (Sechenov University)Endocrinology Research CentreEndocrinology Research CentreEndocrinology Research CentrePirogov Russian National Research Medical UniversityEndocrinology Research CentreEndocrinology Research CentreEndocrinology Research CentreAdrenocortical carcinoma (ACC) is a rare malignant tumor originating in the adrenal cortex and characterized by poor 5-year survival. It occurs with a frequency of 2–4 cases per 2 million in the population. Women are more frequently affected than men and it is mostly detected in the fourth and fifth decades. In the most of cases, the cancerogenesis occurs sporadically because of gene driver mutations in somatic adrenocortical cells, in other cases it can be found as part of a genetically determined syndrome such as Li–Fraumeni syndrome or Wermer's syndrome (multiple endocrine adenomatosis type I). ACC most frequently happens occurs without symptoms in the initial stages leading to poor diagnoses. Because of this lack of early detection, the tumor is not considered malignant reducing the benefits of further treatment. Sometimes the fact that the resected tumor is indeed adrenocortical carcinoma becomes clear only after recurrence, or after the appearance of metastases. We present a case of adrenocortical carcinoma in a 46-year-old woman who went to the doctor in 1.5 year after symptoms were manfested. This clinical case illustrates the consequences of late diagnosis of a malignant tumor. We would like to emphasize the importance of timely detection of a neoplasm, using all of the potential of laboratory-instrumental and genomic analysis. Due to low oncological awareness, our patient was slow to seek medical help, which in turn led not only to metastases, but also to complications in the cardiovascular system.https://ter-arkhiv.ru/0040-3660/article/viewFile/626346/142223adrenocortical carcinomacushing’s syndromehyperandrogenemiamitotane |
| spellingShingle | Evgenia A. Starostina Natalya V. Molashenko Anna R. Levshina Nano V. Pachuashvili Anastassia Chevais Mariya P. Isaeva Kantemir V. Getazheev Dmitry G. Beltsevich Nadezhda M. Platonova Ekaterina A. Troshina Adrenocortical cancer: late diagnosis of the disease on the example of a clinical case. Case report Терапевтический архив adrenocortical carcinoma cushing’s syndrome hyperandrogenemia mitotane |
| title | Adrenocortical cancer: late diagnosis of the disease on the example of a clinical case. Case report |
| title_full | Adrenocortical cancer: late diagnosis of the disease on the example of a clinical case. Case report |
| title_fullStr | Adrenocortical cancer: late diagnosis of the disease on the example of a clinical case. Case report |
| title_full_unstemmed | Adrenocortical cancer: late diagnosis of the disease on the example of a clinical case. Case report |
| title_short | Adrenocortical cancer: late diagnosis of the disease on the example of a clinical case. Case report |
| title_sort | adrenocortical cancer late diagnosis of the disease on the example of a clinical case case report |
| topic | adrenocortical carcinoma cushing’s syndrome hyperandrogenemia mitotane |
| url | https://ter-arkhiv.ru/0040-3660/article/viewFile/626346/142223 |
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