CPT1a gene expression reverses the inflammatory and anti-phagocytic effect of 7-ketocholesterol in RAW264.7 macrophages

CPT1a gene expression reverses the inflammatory and anti-phagocytic effect of 7-ketocholesterol in RAW264.7 macrophages

Abstract Background Macrophage are specialized cells that contributes to the removal of detrimental contents via phagocytosis. Lipid accumulation in macrophages, whether from phagocytosis of dying cells or from circulating oxidized low-density lipoproteins, alters macrophage biology and functionalit...

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Bibliographic Details
Main Authors: Priscila Calle, Angeles Muñoz, Anna Sola, Georgina Hotter
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Lipids in Health and Disease
Subjects:
Macrophage
7-ketocholesterol
CPT1a
Phagocytosis
Inflammation
Online Access:https://doi.org/10.1186/s12944-019-1156-7

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