Acute macular neuroretinopathy following Moderna COVID-19 vaccination
Abstract Purpose To describe the occurrence of an acute macular neuroretinopathy (AMN) after administration of a Moderna COVID-19 Vaccine. Methods Case report. Results A 23-year-old female presented bilateral visual loss one week after the first dose of COVID-19 vaccine. Fundus examination revealed...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2023-06-01
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| Series: | Journal of Ophthalmic Inflammation and Infection |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12348-023-00354-1 |
| _version_ | 1797789660875849728 |
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| author | Olena Protsyk Roberto Gallego-Pinazo Rosa Dolz-Marco |
| author_facet | Olena Protsyk Roberto Gallego-Pinazo Rosa Dolz-Marco |
| author_sort | Olena Protsyk |
| collection | DOAJ |
| description | Abstract Purpose To describe the occurrence of an acute macular neuroretinopathy (AMN) after administration of a Moderna COVID-19 Vaccine. Methods Case report. Results A 23-year-old female presented bilateral visual loss one week after the first dose of COVID-19 vaccine. Fundus examination revealed the classic wedge-shaped lesions with petaloid configuration around both foveas. Hypo-reflective macular lesions are evident in the near-infrared reflectance image. The spectral-domain optical coherence tomography reveled hyperreflectivity of the outer nuclear and plexiform layers, attenuation of the ellipsoid zone and disruption of interdigitation zone corresponding to the lesions. Conclusions Despite the large number of doses of COVID-19 vaccines administered worldwide, there are not many reported cases of AMN. Most of them occurred after viral vector vaccines. Described here is one of the few cases that observed a time period of several days after receiving the Moderna messenger RNA vaccine. It is not possible to establish causality although this suggests an inflammatory or autoimmune response to the vaccine. |
| first_indexed | 2024-03-13T01:53:50Z |
| format | Article |
| id | doaj.art-c8893c19391a4b9097b9f84a6cd27c39 |
| institution | Directory Open Access Journal |
| issn | 1869-5760 |
| language | English |
| last_indexed | 2024-03-13T01:53:50Z |
| publishDate | 2023-06-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Journal of Ophthalmic Inflammation and Infection |
| spelling | doaj.art-c8893c19391a4b9097b9f84a6cd27c392023-07-02T11:23:01ZengSpringerOpenJournal of Ophthalmic Inflammation and Infection1869-57602023-06-011311410.1186/s12348-023-00354-1Acute macular neuroretinopathy following Moderna COVID-19 vaccinationOlena Protsyk0Roberto Gallego-Pinazo1Rosa Dolz-Marco2Department of Ophthalmology, Jaen University HospitalUnit of Macula, Oftalvist ClinicUnit of Macula, Oftalvist ClinicAbstract Purpose To describe the occurrence of an acute macular neuroretinopathy (AMN) after administration of a Moderna COVID-19 Vaccine. Methods Case report. Results A 23-year-old female presented bilateral visual loss one week after the first dose of COVID-19 vaccine. Fundus examination revealed the classic wedge-shaped lesions with petaloid configuration around both foveas. Hypo-reflective macular lesions are evident in the near-infrared reflectance image. The spectral-domain optical coherence tomography reveled hyperreflectivity of the outer nuclear and plexiform layers, attenuation of the ellipsoid zone and disruption of interdigitation zone corresponding to the lesions. Conclusions Despite the large number of doses of COVID-19 vaccines administered worldwide, there are not many reported cases of AMN. Most of them occurred after viral vector vaccines. Described here is one of the few cases that observed a time period of several days after receiving the Moderna messenger RNA vaccine. It is not possible to establish causality although this suggests an inflammatory or autoimmune response to the vaccine.https://doi.org/10.1186/s12348-023-00354-1Acute macular neuroretinopathyCOVID-19Moderna mRNA vaccine |
| spellingShingle | Olena Protsyk Roberto Gallego-Pinazo Rosa Dolz-Marco Acute macular neuroretinopathy following Moderna COVID-19 vaccination Journal of Ophthalmic Inflammation and Infection Acute macular neuroretinopathy COVID-19 Moderna mRNA vaccine |
| title | Acute macular neuroretinopathy following Moderna COVID-19 vaccination |
| title_full | Acute macular neuroretinopathy following Moderna COVID-19 vaccination |
| title_fullStr | Acute macular neuroretinopathy following Moderna COVID-19 vaccination |
| title_full_unstemmed | Acute macular neuroretinopathy following Moderna COVID-19 vaccination |
| title_short | Acute macular neuroretinopathy following Moderna COVID-19 vaccination |
| title_sort | acute macular neuroretinopathy following moderna covid 19 vaccination |
| topic | Acute macular neuroretinopathy COVID-19 Moderna mRNA vaccine |
| url | https://doi.org/10.1186/s12348-023-00354-1 |
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