EFFECTS OF a-TOCOPHEROL ON LIPID PROFILE IN PRIMARY HYPERLIPIDEMIA
Objective : To determine the antihyperlipidemic effects o f a-tocopherol in primary hyperlipidemia. Design: An analytical cohort studyP atien ts an d Methods: This study was conducted in the Department o f Pharmacology and Therapeutics,Basic Medical Sciences Institute o f Jinnah Postgradua...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Dow University of Health Sciences
2008-09-01
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| Series: | Journal of the Dow University of Health Sciences |
| Subjects: | |
| Online Access: | http://www.jduhs.com/index.php/jduhs/article/view/245 |
| Summary: | Objective :
To determine the antihyperlipidemic effects o f a-tocopherol in primary hyperlipidemia.
Design:
An analytical cohort studyP atien ts an d
Methods:
This study was conducted in the Department o f Pharmacology and Therapeutics,Basic Medical Sciences Institute o f Jinnah Postgraduate Medical Center, Karachi, from February to April2001. Newly diagnosed and un-treated primary hyperlipidemic persons o f either gender between the ages17 to 70 years were initially enrolled in the study for a 12 weeks (90 day) trial with fortnightly follow upvisits. The selected patients were divided into 2 groups. The first group (Group-I) was treated with dietrestriction and exercise only. The second group (Group-II) was treated with diet restriction, exercise anda-tocopherol. Results were compared using paired t-test.
Results:
There were 35 patients in all. After treatment w itha-tocopherol, cholesterol reduction was highlysignificant (p<0.01). Triglyceride reduction was significant (p<0.05). Increase in HDL-c level was highlysignificant (p<0.001). The LDL-c reduction was statistically highly significant (p<0.001). VLDL reductionwas also significant (p<0 .0 1 ).When compared between the Groups I and II, the reduction in cholesterol was moderately significant(p<0.01), LDL-c reduction was found to be markedly significant (p<0.01). HDL and VLDL reduction wasalso found to be significant (p<0.05). In comparison there was no significant change in triglyceride level.
Conclusion:
Diet restriction and exercise had significant beneficial effects on lipid profile. When supplementedwitha-tocopherol, there was a highly significant beneficial effect on lipid profile. |
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| ISSN: | 1995-2198 2410-2180 |