PERK signaling through C/EBPδ contributes to ER stress-induced expression of immunomodulatory and tumor promoting chemokines by cancer cells

PERK signaling through C/EBPδ contributes to ER stress-induced expression of immunomodulatory and tumor promoting chemokines by cancer cells

Abstract Cancer cells experience endoplasmic reticulum (ER) stress due to activated oncogenes and conditions of nutrient deprivation and hypoxia. The ensuing unfolded protein response (UPR) is executed by ATF6, IRE1 and PERK pathways. Adaptation to mild ER stress promotes tumor cell survival and agg...

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Bibliographic Details
Main Authors: Namratha Sheshadri, Dipak K. Poria, Shikha Sharan, Ying Hu, Chunhua Yan, Vishal N. Koparde, Kuppusamy Balamurugan, Esta Sterneck
Format: Article
Language:English
Published: Nature Publishing Group 2021-11-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-04318-y

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