ALTERATIONS IN SOME COAGULATION BIOMARKERS OF PULMONARY TUBERCULOSIS SUBJECTS IN THE SETTINGS OF HUMAN IMMUNODEFICIENCY VIRUS INFECTION: AS SEEN IN MAIDUGURI NORTH EASTERN NIGERIA
Background: Synergistic association between Human Immunodeficiency virus (HIV) and pulmonary tuberculosis (PTB) infection has resulted in variable haematological manifestations including coagulopathies; these accelerated the morbidity and mortality burden of HIV/PTB coinfection. Objectives: Based on...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Ntec Specialist
2016-01-01
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| Series: | Kanem Journal of Medical Sciences |
| Subjects: | |
| Online Access: | https://kjmsmedicaljournal.com/wp-content/uploads/2019/09/3_-Obi-SO_et-al_KJMSvol10no1.pdf |
| Summary: | Background: Synergistic association between Human Immunodeficiency virus (HIV) and pulmonary tuberculosis (PTB) infection has resulted in variable haematological manifestations including coagulopathies; these accelerated the morbidity and mortality burden of HIV/PTB coinfection.
Objectives: Based on this preposition, we prospectively evaluated some coagulation biomarkers in a case-controlled study of 102 HIV sero-positive subjects consistent with WHO clinical stages I and II, 56 HIV/PTB co-infected subjects; both groups were therapy naive. Also 104 HIV seronegative healthy blood donors were recruited as control subjects.
Method: All participants were tested for platelet count (PLT), Plasma fibrinogen concentration (PFC), Protein C (PC), prothrombin time (PT) and Activated partial thromboplastin time (APTT). Results: In HIV/PTB co-morbidity PT, APTT were prolonged (P less than 0.001); PLT and PFC were also elevated (P less than 0.001), while PC % activity was down-regulated (P less than 0.01) all in comparison to the HIV group and the controls.
Conclusion: We asserted that alterations occur in some coagulation indices of PTB/HIV coinfected individuals found in our environment. Clinical findings are however, needed to shed more light on these findings to aid patient's management |
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| ISSN: | 2006-4772 2714-2426 |