Genetic copy number variants in myocardial infarction patients with hyperlipidemia
<p>Abstract</p> <p>Background</p> <p>Cardiovascular disease is the chief cause of death in Taiwan and many countries, of which myocardial infarction (MI) is the most serious condition. Hyperlipidemia appears to be a significant cause of myocardial infarction, because it...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2011-11-01
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| Series: | BMC Genomics |
| _version_ | 1818426197923594240 |
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| author | Shia Wei-Chung Ku Tien-Hsiung Tsao Yu-Ming Hsia Chien-Hsun Chang Yung-Ming Huang Ching-Hui Chung Yeh-Ching Hsu Shih-Lan Liang Kae-Woei Hsu Fang-Rong |
| author_facet | Shia Wei-Chung Ku Tien-Hsiung Tsao Yu-Ming Hsia Chien-Hsun Chang Yung-Ming Huang Ching-Hui Chung Yeh-Ching Hsu Shih-Lan Liang Kae-Woei Hsu Fang-Rong |
| author_sort | Shia Wei-Chung |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Cardiovascular disease is the chief cause of death in Taiwan and many countries, of which myocardial infarction (MI) is the most serious condition. Hyperlipidemia appears to be a significant cause of myocardial infarction, because it causes atherosclerosis directly. In recent years, copy number variation (CNV) has been analyzed in genomewide association studies of complex diseases. In this study, CNV was analyzed in blood samples and SNP arrays from 31 myocardial infarction patients with hyperlipidemia.</p> <p>Results</p> <p>We identified seven CNV regions that were associated significantly with hyperlipidemia and myocardial infarction in our patients through multistage analysis (P<0.001), at 1p21.3, 1q31.2 (<it>CDC73</it>), 1q42.2 (<it>DISC1</it>), 3p21.31 (<it>CDCP1</it>), 10q11.21 (<it>RET</it>) 12p12.3 (<it>PIK3C2G</it>) and 16q23.3 (<it>CDH13</it>), respectively. In particular, the CNV region at 10q11.21 was examined by quantitative real-time PCR, the results of which were consistent with microarray findings.</p> <p>Conclusions</p> <p>Our preliminary results constitute an alternative method of evaluating the relationship between CNV regions and cardiovascular disease. These susceptibility CNV regions may be used as biomarkers for early-stage diagnosis of hyperlipidemia and myocardial infarction, rendering them valuable for further research and discussion.</p> |
| first_indexed | 2024-12-14T14:26:01Z |
| format | Article |
| id | doaj.art-c890cf5d645c4d3a862b36252a8ced30 |
| institution | Directory Open Access Journal |
| issn | 1471-2164 |
| language | English |
| last_indexed | 2024-12-14T14:26:01Z |
| publishDate | 2011-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Genomics |
| spelling | doaj.art-c890cf5d645c4d3a862b36252a8ced302022-12-21T22:57:58ZengBMCBMC Genomics1471-21642011-11-0112Suppl 3S2310.1186/1471-2164-12-S3-S23Genetic copy number variants in myocardial infarction patients with hyperlipidemiaShia Wei-ChungKu Tien-HsiungTsao Yu-MingHsia Chien-HsunChang Yung-MingHuang Ching-HuiChung Yeh-ChingHsu Shih-LanLiang Kae-WoeiHsu Fang-Rong<p>Abstract</p> <p>Background</p> <p>Cardiovascular disease is the chief cause of death in Taiwan and many countries, of which myocardial infarction (MI) is the most serious condition. Hyperlipidemia appears to be a significant cause of myocardial infarction, because it causes atherosclerosis directly. In recent years, copy number variation (CNV) has been analyzed in genomewide association studies of complex diseases. In this study, CNV was analyzed in blood samples and SNP arrays from 31 myocardial infarction patients with hyperlipidemia.</p> <p>Results</p> <p>We identified seven CNV regions that were associated significantly with hyperlipidemia and myocardial infarction in our patients through multistage analysis (P<0.001), at 1p21.3, 1q31.2 (<it>CDC73</it>), 1q42.2 (<it>DISC1</it>), 3p21.31 (<it>CDCP1</it>), 10q11.21 (<it>RET</it>) 12p12.3 (<it>PIK3C2G</it>) and 16q23.3 (<it>CDH13</it>), respectively. In particular, the CNV region at 10q11.21 was examined by quantitative real-time PCR, the results of which were consistent with microarray findings.</p> <p>Conclusions</p> <p>Our preliminary results constitute an alternative method of evaluating the relationship between CNV regions and cardiovascular disease. These susceptibility CNV regions may be used as biomarkers for early-stage diagnosis of hyperlipidemia and myocardial infarction, rendering them valuable for further research and discussion.</p> |
| spellingShingle | Shia Wei-Chung Ku Tien-Hsiung Tsao Yu-Ming Hsia Chien-Hsun Chang Yung-Ming Huang Ching-Hui Chung Yeh-Ching Hsu Shih-Lan Liang Kae-Woei Hsu Fang-Rong Genetic copy number variants in myocardial infarction patients with hyperlipidemia BMC Genomics |
| title | Genetic copy number variants in myocardial infarction patients with hyperlipidemia |
| title_full | Genetic copy number variants in myocardial infarction patients with hyperlipidemia |
| title_fullStr | Genetic copy number variants in myocardial infarction patients with hyperlipidemia |
| title_full_unstemmed | Genetic copy number variants in myocardial infarction patients with hyperlipidemia |
| title_short | Genetic copy number variants in myocardial infarction patients with hyperlipidemia |
| title_sort | genetic copy number variants in myocardial infarction patients with hyperlipidemia |
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