Synergistic cardioprotective effects of melatonin and deferoxamine through the improvement of ferritinophagy in doxorubicin-induced acute cardiotoxicity

Synergistic cardioprotective effects of melatonin and deferoxamine through the improvement of ferritinophagy in doxorubicin-induced acute cardiotoxicity

Ferritinophagy is one of the most recent molecular mechanisms affecting cardiac function. In addition, it is one of the pathways by which doxorubicin, one of the anticancer drugs commonly used, negatively impacts the cardiac muscle, leading to cardiac function impairment. This side effect limits the...

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Bibliographic Details
Main Authors: Mira Hanna, Hanan Seddiek, Basma Emad Aboulhoda, George N. B. Morcos, Ahmed M. A. Akabawy, Marawan Abd Elbaset, Abdelsatar Abdelsatar Ibrahim, Mohamed Mansour Khalifa, Ibtesam Mahmoud Khalifah, Mostafa Said Fadel, Tarek Shoukry
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Physiology
Subjects:
ferritinophagy
ferroptosis
iron chelators
melatonin
DOX-induced cardiotoxicity
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2022.1050598/full

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