Emerging role of tumor-related functional peptides encoded by lncRNA and circRNA
Abstract Non-coding RNAs do not encode proteins and regulate various oncological processes. They are also important potential cancer diagnostic and prognostic biomarkers. Bioinformatics and translation omics have begun to elucidate the roles and modes of action of the functional peptides encoded by...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-02-01
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| Series: | Molecular Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12943-020-1147-3 |
| _version_ | 1819275400682930176 |
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| author | Pan Wu Yongzhen Mo Miao Peng Ting Tang Yu Zhong Xiangying Deng Fang Xiong Can Guo Xu Wu Yong Li Xiaoling Li Guiyuan Li Zhaoyang Zeng Wei Xiong |
| author_facet | Pan Wu Yongzhen Mo Miao Peng Ting Tang Yu Zhong Xiangying Deng Fang Xiong Can Guo Xu Wu Yong Li Xiaoling Li Guiyuan Li Zhaoyang Zeng Wei Xiong |
| author_sort | Pan Wu |
| collection | DOAJ |
| description | Abstract Non-coding RNAs do not encode proteins and regulate various oncological processes. They are also important potential cancer diagnostic and prognostic biomarkers. Bioinformatics and translation omics have begun to elucidate the roles and modes of action of the functional peptides encoded by ncRNA. Here, recent advances in long non-coding RNA (lncRNA) and circular RNA (circRNA)-encoded small peptides are compiled and synthesized. We introduce both the computational and analytical methods used to forecast prospective ncRNAs encoding oncologically functional oligopeptides. We also present numerous specific lncRNA and circRNA-encoded proteins and their cancer-promoting or cancer-inhibiting molecular mechanisms. This information may expedite the discovery, development, and optimization of novel and efficacious cancer diagnostic, therapeutic, and prognostic protein-based tools derived from non-coding RNAs. The role of ncRNA-encoding functional peptides has promising application perspectives and potential challenges in cancer research. The aim of this review is to provide a theoretical basis and relevant references, which may promote the discovery of more functional peptides encoded by ncRNAs, and further develop novel anticancer therapeutic targets, as well as diagnostic and prognostic cancer markers. |
| first_indexed | 2024-12-23T23:23:44Z |
| format | Article |
| id | doaj.art-c8912c66ba0247a8a2bceb6d5df583e8 |
| institution | Directory Open Access Journal |
| issn | 1476-4598 |
| language | English |
| last_indexed | 2024-12-23T23:23:44Z |
| publishDate | 2020-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Cancer |
| spelling | doaj.art-c8912c66ba0247a8a2bceb6d5df583e82022-12-21T17:26:17ZengBMCMolecular Cancer1476-45982020-02-0119111410.1186/s12943-020-1147-3Emerging role of tumor-related functional peptides encoded by lncRNA and circRNAPan Wu0Yongzhen Mo1Miao Peng2Ting Tang3Yu Zhong4Xiangying Deng5Fang Xiong6Can Guo7Xu Wu8Yong Li9Xiaoling Li10Guiyuan Li11Zhaoyang Zeng12Wei Xiong13NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Translational Radiation Oncology, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South UniversityKey Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South UniversityKey Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South UniversityKey Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South UniversityKey Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South UniversityKey Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South UniversityKey Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South UniversityKey Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South UniversityNHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Translational Radiation Oncology, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South UniversityDepartment of Medicine, Dan L Duncan Comprehensive Cancer Center, Baylor College of MedicineKey Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South UniversityNHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Translational Radiation Oncology, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South UniversityNHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Translational Radiation Oncology, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South UniversityNHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Translational Radiation Oncology, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South UniversityAbstract Non-coding RNAs do not encode proteins and regulate various oncological processes. They are also important potential cancer diagnostic and prognostic biomarkers. Bioinformatics and translation omics have begun to elucidate the roles and modes of action of the functional peptides encoded by ncRNA. Here, recent advances in long non-coding RNA (lncRNA) and circular RNA (circRNA)-encoded small peptides are compiled and synthesized. We introduce both the computational and analytical methods used to forecast prospective ncRNAs encoding oncologically functional oligopeptides. We also present numerous specific lncRNA and circRNA-encoded proteins and their cancer-promoting or cancer-inhibiting molecular mechanisms. This information may expedite the discovery, development, and optimization of novel and efficacious cancer diagnostic, therapeutic, and prognostic protein-based tools derived from non-coding RNAs. The role of ncRNA-encoding functional peptides has promising application perspectives and potential challenges in cancer research. The aim of this review is to provide a theoretical basis and relevant references, which may promote the discovery of more functional peptides encoded by ncRNAs, and further develop novel anticancer therapeutic targets, as well as diagnostic and prognostic cancer markers.https://doi.org/10.1186/s12943-020-1147-3cancercircRNAlncRNApeptide |
| spellingShingle | Pan Wu Yongzhen Mo Miao Peng Ting Tang Yu Zhong Xiangying Deng Fang Xiong Can Guo Xu Wu Yong Li Xiaoling Li Guiyuan Li Zhaoyang Zeng Wei Xiong Emerging role of tumor-related functional peptides encoded by lncRNA and circRNA Molecular Cancer cancer circRNA lncRNA peptide |
| title | Emerging role of tumor-related functional peptides encoded by lncRNA and circRNA |
| title_full | Emerging role of tumor-related functional peptides encoded by lncRNA and circRNA |
| title_fullStr | Emerging role of tumor-related functional peptides encoded by lncRNA and circRNA |
| title_full_unstemmed | Emerging role of tumor-related functional peptides encoded by lncRNA and circRNA |
| title_short | Emerging role of tumor-related functional peptides encoded by lncRNA and circRNA |
| title_sort | emerging role of tumor related functional peptides encoded by lncrna and circrna |
| topic | cancer circRNA lncRNA peptide |
| url | https://doi.org/10.1186/s12943-020-1147-3 |
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