Chemotherapeutic drug screening in 3D-Bioengineered human myobundles provides insight into taxane-induced myotoxicities

Chemotherapeutic drug screening in 3D-Bioengineered human myobundles provides insight into taxane-induced myotoxicities

Summary: Two prominent frontline breast cancer (BC) chemotherapies commonly used in combination, doxorubicin (DOX) and docetaxel (TAX), are associated with long-lasting cardiometabolic and musculoskeletal side effects. Whereas DOX has been linked to mitochondrial dysfunction, mechanisms underlying T...

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Bibliographic Details
Main Authors: Maria J. Torres, Xu Zhang, Dorothy H. Slentz, Timothy R. Koves, Hailee Patel, George A. Truskey, Deborah M. Muoio
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:iScience
Subjects:
Pharmacology
Biological sciences
Cancer
Bioengineering
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222014614

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