Serum cold-inducible RNA-binding protein levels as a potential biomarker for systemic sclerosis-associated interstitial lung disease
Abstract Systemic sclerosis (SSc) is a complex autoimmune disease characterized by fibrotic, inflammatory, and vascular dysfunction. Danger-associated molecular patterns (DAMPs)-mediated inflammasome activation has been reported to be involved in the pathogenesis of SSc. Cold-inducible RNA-binding p...
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| Format: | Article |
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Nature Portfolio
2023-03-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-32231-1 |
| _version_ | 1797853878304112640 |
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| author | Issei Omori Hayakazu Sumida Ayaka Sugimori Moe Sakakibara Mariko Urano-Takaoka Okuto Iwasawa Hinako Saito Ai Matsuno Shinichi Sato |
| author_facet | Issei Omori Hayakazu Sumida Ayaka Sugimori Moe Sakakibara Mariko Urano-Takaoka Okuto Iwasawa Hinako Saito Ai Matsuno Shinichi Sato |
| author_sort | Issei Omori |
| collection | DOAJ |
| description | Abstract Systemic sclerosis (SSc) is a complex autoimmune disease characterized by fibrotic, inflammatory, and vascular dysfunction. Danger-associated molecular patterns (DAMPs)-mediated inflammasome activation has been reported to be involved in the pathogenesis of SSc. Cold-inducible RNA-binding protein (CIRP) is newly identified as a DAMP. Here we examined the clinical significance of serum levels of CIRP in 60 patients with SSc and 20 healthy control patients (HCs) using an enzyme-linked immunosorbent assay. Serum CIRP levels in diffuse cutaneous SSc (dcSSc) patients were significantly increased compared with limited cutaneous SSc (lcSSc) patients or HCs. When examining the relationship with SSc-specific parameters, serum CIRP levels with the presence of interstitial lung disease (ILD) were higher than those without ILD. In detail, serum CIRP levels correlated negatively with the percent predicted diffusing capacity for carbon monoxide and positively with levels of Krebs von den Lungen-6. In addition, elevated serum CIRP levels declined along with decreased SSc-ILD activity in patients who received immunosuppressive therapy. These results suggest that CIRP may play a role in the development of ILD in SSc. Moreover, CIRP could serve as a useful serological marker of SSc-ILD in terms of disease activity and therapeutic effects. |
| first_indexed | 2024-04-09T19:56:51Z |
| format | Article |
| id | doaj.art-c893dbff6d7345c7b79652ab8cf152ab |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-09T19:56:51Z |
| publishDate | 2023-03-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj.art-c893dbff6d7345c7b79652ab8cf152ab2023-04-03T05:25:09ZengNature PortfolioScientific Reports2045-23222023-03-011311710.1038/s41598-023-32231-1Serum cold-inducible RNA-binding protein levels as a potential biomarker for systemic sclerosis-associated interstitial lung diseaseIssei Omori0Hayakazu Sumida1Ayaka Sugimori2Moe Sakakibara3Mariko Urano-Takaoka4Okuto Iwasawa5Hinako Saito6Ai Matsuno7Shinichi Sato8Department of Dermatology, Faculty of Medicine, The University of TokyoDepartment of Dermatology, Faculty of Medicine, The University of TokyoDepartment of Dermatology, Faculty of Medicine, The University of TokyoDepartment of Dermatology, Faculty of Medicine, The University of TokyoDepartment of Dermatology, Faculty of Medicine, The University of TokyoDepartment of Dermatology, Faculty of Medicine, The University of TokyoDepartment of Dermatology, Faculty of Medicine, The University of TokyoDepartment of Dermatology, Faculty of Medicine, The University of TokyoDepartment of Dermatology, Faculty of Medicine, The University of TokyoAbstract Systemic sclerosis (SSc) is a complex autoimmune disease characterized by fibrotic, inflammatory, and vascular dysfunction. Danger-associated molecular patterns (DAMPs)-mediated inflammasome activation has been reported to be involved in the pathogenesis of SSc. Cold-inducible RNA-binding protein (CIRP) is newly identified as a DAMP. Here we examined the clinical significance of serum levels of CIRP in 60 patients with SSc and 20 healthy control patients (HCs) using an enzyme-linked immunosorbent assay. Serum CIRP levels in diffuse cutaneous SSc (dcSSc) patients were significantly increased compared with limited cutaneous SSc (lcSSc) patients or HCs. When examining the relationship with SSc-specific parameters, serum CIRP levels with the presence of interstitial lung disease (ILD) were higher than those without ILD. In detail, serum CIRP levels correlated negatively with the percent predicted diffusing capacity for carbon monoxide and positively with levels of Krebs von den Lungen-6. In addition, elevated serum CIRP levels declined along with decreased SSc-ILD activity in patients who received immunosuppressive therapy. These results suggest that CIRP may play a role in the development of ILD in SSc. Moreover, CIRP could serve as a useful serological marker of SSc-ILD in terms of disease activity and therapeutic effects.https://doi.org/10.1038/s41598-023-32231-1 |
| spellingShingle | Issei Omori Hayakazu Sumida Ayaka Sugimori Moe Sakakibara Mariko Urano-Takaoka Okuto Iwasawa Hinako Saito Ai Matsuno Shinichi Sato Serum cold-inducible RNA-binding protein levels as a potential biomarker for systemic sclerosis-associated interstitial lung disease Scientific Reports |
| title | Serum cold-inducible RNA-binding protein levels as a potential biomarker for systemic sclerosis-associated interstitial lung disease |
| title_full | Serum cold-inducible RNA-binding protein levels as a potential biomarker for systemic sclerosis-associated interstitial lung disease |
| title_fullStr | Serum cold-inducible RNA-binding protein levels as a potential biomarker for systemic sclerosis-associated interstitial lung disease |
| title_full_unstemmed | Serum cold-inducible RNA-binding protein levels as a potential biomarker for systemic sclerosis-associated interstitial lung disease |
| title_short | Serum cold-inducible RNA-binding protein levels as a potential biomarker for systemic sclerosis-associated interstitial lung disease |
| title_sort | serum cold inducible rna binding protein levels as a potential biomarker for systemic sclerosis associated interstitial lung disease |
| url | https://doi.org/10.1038/s41598-023-32231-1 |
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