The Wnt/β-catenin signalling pathway in Haematological Neoplasms
Abstract Leukaemia and lymphoma are common malignancies. The Wnt pathway is a complex network of proteins regulating cell proliferation and differentiation, as well as cancer development, and is divided into the Wnt/β-catenin signalling pathway (the canonical Wnt signalling pathway) and the noncanon...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-10-01
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| Series: | Biomarker Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40364-022-00418-9 |
| _version_ | 1798030011928674304 |
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| author | Siwei Yu Ruyue Han Runliang Gan |
| author_facet | Siwei Yu Ruyue Han Runliang Gan |
| author_sort | Siwei Yu |
| collection | DOAJ |
| description | Abstract Leukaemia and lymphoma are common malignancies. The Wnt pathway is a complex network of proteins regulating cell proliferation and differentiation, as well as cancer development, and is divided into the Wnt/β-catenin signalling pathway (the canonical Wnt signalling pathway) and the noncanonical Wnt signalling pathway. The Wnt/β-catenin signalling pathway is highly conserved evolutionarily, and activation or inhibition of either of the pathways may lead to cancer development and progression. The aim of this review is to analyse the mechanisms of action of related molecules in the Wnt/β-catenin pathway in haematologic malignancies and their feasibility as therapeutic targets. |
| first_indexed | 2024-04-11T19:34:31Z |
| format | Article |
| id | doaj.art-c894943a9a5c49dfa25e7aa478e78308 |
| institution | Directory Open Access Journal |
| issn | 2050-7771 |
| language | English |
| last_indexed | 2024-04-11T19:34:31Z |
| publishDate | 2022-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Biomarker Research |
| spelling | doaj.art-c894943a9a5c49dfa25e7aa478e783082022-12-22T04:06:55ZengBMCBiomarker Research2050-77712022-10-0110111310.1186/s40364-022-00418-9The Wnt/β-catenin signalling pathway in Haematological NeoplasmsSiwei Yu0Ruyue Han1Runliang Gan2Cancer Research Institute, Key Laboratory of Cancer Cellular and Molecular Pathology in Hunan Province, Hengyang Medical School, University of South ChinaCancer Research Institute, Key Laboratory of Cancer Cellular and Molecular Pathology in Hunan Province, Hengyang Medical School, University of South ChinaCancer Research Institute, Key Laboratory of Cancer Cellular and Molecular Pathology in Hunan Province, Hengyang Medical School, University of South ChinaAbstract Leukaemia and lymphoma are common malignancies. The Wnt pathway is a complex network of proteins regulating cell proliferation and differentiation, as well as cancer development, and is divided into the Wnt/β-catenin signalling pathway (the canonical Wnt signalling pathway) and the noncanonical Wnt signalling pathway. The Wnt/β-catenin signalling pathway is highly conserved evolutionarily, and activation or inhibition of either of the pathways may lead to cancer development and progression. The aim of this review is to analyse the mechanisms of action of related molecules in the Wnt/β-catenin pathway in haematologic malignancies and their feasibility as therapeutic targets.https://doi.org/10.1186/s40364-022-00418-9Wnt/β-catenin signalling pathwayHaematologic neoplasmsLeukaemiaLymphomaMultiple myeloma |
| spellingShingle | Siwei Yu Ruyue Han Runliang Gan The Wnt/β-catenin signalling pathway in Haematological Neoplasms Biomarker Research Wnt/β-catenin signalling pathway Haematologic neoplasms Leukaemia Lymphoma Multiple myeloma |
| title | The Wnt/β-catenin signalling pathway in Haematological Neoplasms |
| title_full | The Wnt/β-catenin signalling pathway in Haematological Neoplasms |
| title_fullStr | The Wnt/β-catenin signalling pathway in Haematological Neoplasms |
| title_full_unstemmed | The Wnt/β-catenin signalling pathway in Haematological Neoplasms |
| title_short | The Wnt/β-catenin signalling pathway in Haematological Neoplasms |
| title_sort | wnt β catenin signalling pathway in haematological neoplasms |
| topic | Wnt/β-catenin signalling pathway Haematologic neoplasms Leukaemia Lymphoma Multiple myeloma |
| url | https://doi.org/10.1186/s40364-022-00418-9 |
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