Germline RET Leu56Met Variant Is Likely Not Causative of Multiple Endocrine Neoplasia Type 2

Germline RET Leu56Met Variant Is Likely Not Causative of Multiple Endocrine Neoplasia Type 2

Activating variants in the receptor tyrosine kinase REarranged during Transfection (RET) cause multiple endocrine neoplasia type 2 (MEN 2), an autosomal dominantly inherited cancer-susceptibility syndrome. The variant c.166C>A, p.Leu56Met in RET was recently reported in two patients with medu...

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Bibliographic Details
Main Authors: Anna Reimer Hansen, Line Borgwardt, Åse Krogh Rasmussen, Christian Godballe, Morten Møller Poulsen, Filipe G. Vieira, Jes Sloth Mathiesen, Maria Rossing
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Endocrinology
Subjects:
multiple endocrine neoplasia type 2
medullary thyroid cancer
RET
Leu56Met
Genetics
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2021.764512/full

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