Biomarkers in Forensic Diagnosis of Sudden Cardiac Death (SCD)
Abstract Diagnosis of sudden cardiac death (SCD) is challenging for medical professionals. For this reason, to make diagnosis easier for forensic pathologists, there is a pressing need for the use of biomarkers. This article highlights biomarkers that can be used in the postmortem diagnosis of SCD....
| Main Authors: | , , |
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| Format: | Article |
| Language: | Arabic |
| Published: |
Naif University Publishing House
2019-05-01
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| Series: | Arab Journal of Forensic Sciences & Forensic Medicine |
| Subjects: | |
| Online Access: | https://journals.nauss.edu.sa/index.php/AJFSFM/article/view/812 |
| _version_ | 1797265140312178688 |
|---|---|
| author | Saikat Das Soumeek Chowdhuri Ritwik Ghosh |
| author_facet | Saikat Das Soumeek Chowdhuri Ritwik Ghosh |
| author_sort | Saikat Das |
| collection | DOAJ |
| description | Abstract
Diagnosis of sudden cardiac death (SCD) is challenging for
medical professionals. For this reason, to make diagnosis easier for
forensic pathologists, there is a pressing need for the use of biomarkers.
This article highlights biomarkers that can be used in the
postmortem diagnosis of SCD.
Cardiac troponins, high-sensitivity C-reactive protein, and creatine
kinase-MB have proven to be very useful for this purpose.
Lactate dehydrogenase, myoglobin and tumor necrosis factor α, although
useful, are not efficient enough to be included in the list of
biomarkers for the diagnosis of SCD.
Previous studies have shown both positive and negative results
for natriuretic peptides as a biomarker, and further studies are required
to confirm its use as a biomarker for diagnosis of SCD in autopsy
cases. In living subjects, a multi-marker strategy is useful in
predicting risk of cardiovascular deaths. It is suggested that for the
diagnosis of SCD, a multi-marker strategy may be more efficient.
However, more studies are required to confirm this. |
| first_indexed | 2024-04-25T00:40:04Z |
| format | Article |
| id | doaj.art-c89679cd52ac47889b30ef7fe04fbb22 |
| institution | Directory Open Access Journal |
| issn | 1658-6786 1658-6794 |
| language | Arabic |
| last_indexed | 2024-04-25T00:40:04Z |
| publishDate | 2019-05-01 |
| publisher | Naif University Publishing House |
| record_format | Article |
| series | Arab Journal of Forensic Sciences & Forensic Medicine |
| spelling | doaj.art-c89679cd52ac47889b30ef7fe04fbb222024-03-12T12:28:08ZaraNaif University Publishing HouseArab Journal of Forensic Sciences & Forensic Medicine1658-67861658-67942019-05-01191255125510.26735/16586794.2019.011335Biomarkers in Forensic Diagnosis of Sudden Cardiac Death (SCD)Saikat DasSoumeek ChowdhuriRitwik GhoshAbstract Diagnosis of sudden cardiac death (SCD) is challenging for medical professionals. For this reason, to make diagnosis easier for forensic pathologists, there is a pressing need for the use of biomarkers. This article highlights biomarkers that can be used in the postmortem diagnosis of SCD. Cardiac troponins, high-sensitivity C-reactive protein, and creatine kinase-MB have proven to be very useful for this purpose. Lactate dehydrogenase, myoglobin and tumor necrosis factor α, although useful, are not efficient enough to be included in the list of biomarkers for the diagnosis of SCD. Previous studies have shown both positive and negative results for natriuretic peptides as a biomarker, and further studies are required to confirm its use as a biomarker for diagnosis of SCD in autopsy cases. In living subjects, a multi-marker strategy is useful in predicting risk of cardiovascular deaths. It is suggested that for the diagnosis of SCD, a multi-marker strategy may be more efficient. However, more studies are required to confirm this.https://journals.nauss.edu.sa/index.php/AJFSFM/article/view/812forensic sciencesudden cardiac deathbiomarkersforensic diagnosis. |
| spellingShingle | Saikat Das Soumeek Chowdhuri Ritwik Ghosh Biomarkers in Forensic Diagnosis of Sudden Cardiac Death (SCD) Arab Journal of Forensic Sciences & Forensic Medicine forensic science sudden cardiac death biomarkers forensic diagnosis. |
| title | Biomarkers in Forensic Diagnosis of Sudden Cardiac Death (SCD) |
| title_full | Biomarkers in Forensic Diagnosis of Sudden Cardiac Death (SCD) |
| title_fullStr | Biomarkers in Forensic Diagnosis of Sudden Cardiac Death (SCD) |
| title_full_unstemmed | Biomarkers in Forensic Diagnosis of Sudden Cardiac Death (SCD) |
| title_short | Biomarkers in Forensic Diagnosis of Sudden Cardiac Death (SCD) |
| title_sort | biomarkers in forensic diagnosis of sudden cardiac death scd |
| topic | forensic science sudden cardiac death biomarkers forensic diagnosis. |
| url | https://journals.nauss.edu.sa/index.php/AJFSFM/article/view/812 |
| work_keys_str_mv | AT saikatdas biomarkersinforensicdiagnosisofsuddencardiacdeathscd AT soumeekchowdhuri biomarkersinforensicdiagnosisofsuddencardiacdeathscd AT ritwikghosh biomarkersinforensicdiagnosisofsuddencardiacdeathscd |