Management Strategies Of Palmar Hyperhidrosis: Challenges And Solutions
Stamatios Gregoriou,1 Polytimi Sidiropoulou,1 Georgios Kontochristopoulos,2 Dimitrios Rigopoulos1 11st Department of Dermatology-Venereology, National and Kapodistrian University of Athens, Faculty of Medicine, “A. Sygros” Hospital for Cutaneous & Venereal Diseases, Athen...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2019-10-01
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| Series: | Clinical, Cosmetic and Investigational Dermatology |
| Subjects: | |
| Online Access: | https://www.dovepress.com/management-strategies-of-palmar-hyperhidrosis-challenges-and-solutions-peer-reviewed-article-CCID |
| _version_ | 1819080552525856768 |
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| author | Gregoriou S Sidiropoulou P Kontochristopoulos G Rigopoulos D |
| author_facet | Gregoriou S Sidiropoulou P Kontochristopoulos G Rigopoulos D |
| author_sort | Gregoriou S |
| collection | DOAJ |
| description | Stamatios Gregoriou,1 Polytimi Sidiropoulou,1 Georgios Kontochristopoulos,2 Dimitrios Rigopoulos1 11st Department of Dermatology-Venereology, National and Kapodistrian University of Athens, Faculty of Medicine, “A. Sygros” Hospital for Cutaneous & Venereal Diseases, Athens, Greece; 2State Department of Dermatology-Venereology, “A. Sygros” Hospital for Cutaneous & Venereal Diseases, Athens, GreeceCorrespondence: Stamatios GregoriouDermatology, “A. Sygros” Hospital for Skin Diseases, 5 Ionos Dragoumi str, Athens GR-16121, GreeceTel +30 21 2107265198Fax +30 21 2107211122Email stamgreg@yahoo.grAbstract: Palmar hyperhidrosis is a potentially disabling condition for which management remains a therapeutic challenge. Given the significant impact on quality of life, various treatment options are available, ranging from topical agents and medical devices to systemic therapies and surgical interventions. Nonsurgical approaches, i.e. topical antiperspirants, botulinum toxin injections, iontophoresis, and systemic agents, are all supported by the current literature. Patients with mild-to-moderate disease can often benefit from topical therapies only. As disease severity progresses, systemic oral medication, such as anticholinergic drugs, usually becomes necessary. Last-line surgical approaches (sympathetic denervation) should be reserved for severe refractory cases. Recently, therapeutic strategies have been evolving with several new agents emerging as promising alternatives in clinical trials. In practice, however, each modality comes with its own benefits and risks. An individual therapeutic ladder is generally recommended, taking into account disease severity, benefit-to-risk profile, treatment cost, patient preference, and clinician expertise. This review will provide an update on current and emerging concepts of management for excessive hand sweating to help clinicians optimize therapeutic decision-making.Keywords: iontophoresis, aluminum chloride, botulinum toxin, anticholinergics, oxybutynin, glycopyrrolate, sympathectomy |
| first_indexed | 2024-12-21T19:46:42Z |
| format | Article |
| id | doaj.art-c899bbbf5eb04b66ab6942619d9d9e89 |
| institution | Directory Open Access Journal |
| issn | 1178-7015 |
| language | English |
| last_indexed | 2024-12-21T19:46:42Z |
| publishDate | 2019-10-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical, Cosmetic and Investigational Dermatology |
| spelling | doaj.art-c899bbbf5eb04b66ab6942619d9d9e892022-12-21T18:52:18ZengDove Medical PressClinical, Cosmetic and Investigational Dermatology1178-70152019-10-01Volume 1273374448949Management Strategies Of Palmar Hyperhidrosis: Challenges And SolutionsGregoriou SSidiropoulou PKontochristopoulos GRigopoulos DStamatios Gregoriou,1 Polytimi Sidiropoulou,1 Georgios Kontochristopoulos,2 Dimitrios Rigopoulos1 11st Department of Dermatology-Venereology, National and Kapodistrian University of Athens, Faculty of Medicine, “A. Sygros” Hospital for Cutaneous & Venereal Diseases, Athens, Greece; 2State Department of Dermatology-Venereology, “A. Sygros” Hospital for Cutaneous & Venereal Diseases, Athens, GreeceCorrespondence: Stamatios GregoriouDermatology, “A. Sygros” Hospital for Skin Diseases, 5 Ionos Dragoumi str, Athens GR-16121, GreeceTel +30 21 2107265198Fax +30 21 2107211122Email stamgreg@yahoo.grAbstract: Palmar hyperhidrosis is a potentially disabling condition for which management remains a therapeutic challenge. Given the significant impact on quality of life, various treatment options are available, ranging from topical agents and medical devices to systemic therapies and surgical interventions. Nonsurgical approaches, i.e. topical antiperspirants, botulinum toxin injections, iontophoresis, and systemic agents, are all supported by the current literature. Patients with mild-to-moderate disease can often benefit from topical therapies only. As disease severity progresses, systemic oral medication, such as anticholinergic drugs, usually becomes necessary. Last-line surgical approaches (sympathetic denervation) should be reserved for severe refractory cases. Recently, therapeutic strategies have been evolving with several new agents emerging as promising alternatives in clinical trials. In practice, however, each modality comes with its own benefits and risks. An individual therapeutic ladder is generally recommended, taking into account disease severity, benefit-to-risk profile, treatment cost, patient preference, and clinician expertise. This review will provide an update on current and emerging concepts of management for excessive hand sweating to help clinicians optimize therapeutic decision-making.Keywords: iontophoresis, aluminum chloride, botulinum toxin, anticholinergics, oxybutynin, glycopyrrolate, sympathectomyhttps://www.dovepress.com/management-strategies-of-palmar-hyperhidrosis-challenges-and-solutions-peer-reviewed-article-CCIDiontophoresisaluminum chloridebotulinum toxinanticholinergicsoxybutyninglycopyrrolatesympathectomy. |
| spellingShingle | Gregoriou S Sidiropoulou P Kontochristopoulos G Rigopoulos D Management Strategies Of Palmar Hyperhidrosis: Challenges And Solutions Clinical, Cosmetic and Investigational Dermatology iontophoresis aluminum chloride botulinum toxin anticholinergics oxybutynin glycopyrrolate sympathectomy. |
| title | Management Strategies Of Palmar Hyperhidrosis: Challenges And Solutions |
| title_full | Management Strategies Of Palmar Hyperhidrosis: Challenges And Solutions |
| title_fullStr | Management Strategies Of Palmar Hyperhidrosis: Challenges And Solutions |
| title_full_unstemmed | Management Strategies Of Palmar Hyperhidrosis: Challenges And Solutions |
| title_short | Management Strategies Of Palmar Hyperhidrosis: Challenges And Solutions |
| title_sort | management strategies of palmar hyperhidrosis challenges and solutions |
| topic | iontophoresis aluminum chloride botulinum toxin anticholinergics oxybutynin glycopyrrolate sympathectomy. |
| url | https://www.dovepress.com/management-strategies-of-palmar-hyperhidrosis-challenges-and-solutions-peer-reviewed-article-CCID |
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