Reduced Global-Brain Functional Connectivity and Its Relationship With Symptomatic Severity in Cervical Dystonia
Background: Altered functional connectivity (FC) is related to pathophysiology of patients with cervical dystonia (CD). However, inconsistent results may be obtained due to different selected regions of interest. We explored voxel-wise brain-wide FC changes in patients with CD at rest in an unbiased...
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Frontiers Media S.A.
2020-01-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2019.01358/full |
| _version_ | 1819095215843049472 |
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| author | Pan Pan Pan Pan Shubao Wei Yangpan Ou Yangpan Ou Wenyan Jiang Wenmei Li Yiwu Lei Feng Liu Wenbin Guo Wenbin Guo Shuguang Luo |
| author_facet | Pan Pan Pan Pan Shubao Wei Yangpan Ou Yangpan Ou Wenyan Jiang Wenmei Li Yiwu Lei Feng Liu Wenbin Guo Wenbin Guo Shuguang Luo |
| author_sort | Pan Pan |
| collection | DOAJ |
| description | Background: Altered functional connectivity (FC) is related to pathophysiology of patients with cervical dystonia (CD). However, inconsistent results may be obtained due to different selected regions of interest. We explored voxel-wise brain-wide FC changes in patients with CD at rest in an unbiased manner and analyzed their correlations with symptomatic severity using the Tsui scale.Method: A total of 19 patients with CD and 21 sex- and age-matched healthy controls underwent resting-state functional magnetic resonance imaging scans. Global-brain FC (GFC) was applied to analyze the images. Support vector machine was used to distinguish the patients from the controls.Results: Patients with CD exhibited decreased GFC in the right precentral gyrus and right supplementary motor area (SMA) that belonged to the M1-SMA motor network. Significantly negative correlation was observed between GFC values in the right precentral gyrus and symptomatic severity in the patients (r = −0.476, p = 0.039, uncorrected). Decreased GFC values in these two brain regions could be utilized to differentiate the patients from the controls with good accuracies, sensitivities and specificities (83.33, 85.71, and 80.95% in the right precentral gyrus; and 87.59, 89.49, and 85.71% in the right SMA).Conclusions: Our investigation suggests that patients with CD show reduced GFC in brain regions of the M1-SMA motor network and provides further insights into the pathophysiology of CD. GFC values in the right precentral gyrus and right SMA may be used as potential biomarkers to recognize the patients from the controls. |
| first_indexed | 2024-12-21T23:39:46Z |
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| language | English |
| last_indexed | 2024-12-21T23:39:46Z |
| publishDate | 2020-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-c899eae958c74247b0995db40ef72e1b2022-12-21T18:46:16ZengFrontiers Media S.A.Frontiers in Neurology1664-22952020-01-011010.3389/fneur.2019.01358484639Reduced Global-Brain Functional Connectivity and Its Relationship With Symptomatic Severity in Cervical DystoniaPan Pan0Pan Pan1Shubao Wei2Yangpan Ou3Yangpan Ou4Wenyan Jiang5Wenmei Li6Yiwu Lei7Feng Liu8Wenbin Guo9Wenbin Guo10Shuguang Luo11Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, ChinaNational Clinical Research Center on Mental Disorders, Changsha, ChinaDepartment of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning, ChinaDepartment of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, ChinaNational Clinical Research Center on Mental Disorders, Changsha, ChinaDepartment of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning, ChinaDepartment of Radiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, ChinaDepartment of Radiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, ChinaDepartment of Radiology, Tianjin Medical University General Hospital, Tianjin, ChinaDepartment of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, ChinaNational Clinical Research Center on Mental Disorders, Changsha, ChinaDepartment of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning, ChinaBackground: Altered functional connectivity (FC) is related to pathophysiology of patients with cervical dystonia (CD). However, inconsistent results may be obtained due to different selected regions of interest. We explored voxel-wise brain-wide FC changes in patients with CD at rest in an unbiased manner and analyzed their correlations with symptomatic severity using the Tsui scale.Method: A total of 19 patients with CD and 21 sex- and age-matched healthy controls underwent resting-state functional magnetic resonance imaging scans. Global-brain FC (GFC) was applied to analyze the images. Support vector machine was used to distinguish the patients from the controls.Results: Patients with CD exhibited decreased GFC in the right precentral gyrus and right supplementary motor area (SMA) that belonged to the M1-SMA motor network. Significantly negative correlation was observed between GFC values in the right precentral gyrus and symptomatic severity in the patients (r = −0.476, p = 0.039, uncorrected). Decreased GFC values in these two brain regions could be utilized to differentiate the patients from the controls with good accuracies, sensitivities and specificities (83.33, 85.71, and 80.95% in the right precentral gyrus; and 87.59, 89.49, and 85.71% in the right SMA).Conclusions: Our investigation suggests that patients with CD show reduced GFC in brain regions of the M1-SMA motor network and provides further insights into the pathophysiology of CD. GFC values in the right precentral gyrus and right SMA may be used as potential biomarkers to recognize the patients from the controls.https://www.frontiersin.org/article/10.3389/fneur.2019.01358/fullcervical dystoniaglobal-brain functional connectivityprecentral gyrussupplementary motor areanetwork |
| spellingShingle | Pan Pan Pan Pan Shubao Wei Yangpan Ou Yangpan Ou Wenyan Jiang Wenmei Li Yiwu Lei Feng Liu Wenbin Guo Wenbin Guo Shuguang Luo Reduced Global-Brain Functional Connectivity and Its Relationship With Symptomatic Severity in Cervical Dystonia Frontiers in Neurology cervical dystonia global-brain functional connectivity precentral gyrus supplementary motor area network |
| title | Reduced Global-Brain Functional Connectivity and Its Relationship With Symptomatic Severity in Cervical Dystonia |
| title_full | Reduced Global-Brain Functional Connectivity and Its Relationship With Symptomatic Severity in Cervical Dystonia |
| title_fullStr | Reduced Global-Brain Functional Connectivity and Its Relationship With Symptomatic Severity in Cervical Dystonia |
| title_full_unstemmed | Reduced Global-Brain Functional Connectivity and Its Relationship With Symptomatic Severity in Cervical Dystonia |
| title_short | Reduced Global-Brain Functional Connectivity and Its Relationship With Symptomatic Severity in Cervical Dystonia |
| title_sort | reduced global brain functional connectivity and its relationship with symptomatic severity in cervical dystonia |
| topic | cervical dystonia global-brain functional connectivity precentral gyrus supplementary motor area network |
| url | https://www.frontiersin.org/article/10.3389/fneur.2019.01358/full |
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