Potential pre-activation strategies for improving therapeutic efficacy of mesenchymal stem cells: current status and future prospects
Abstract Mesenchymal stem cell (MSC)-based therapy has been considered as a promising approach targeting a variety of intractable diseases due to remarkable multiple effect of MSCs, such as multilineage differentiation, immunomodulatory property, and pro-regenerative capacity. However, poor engraftm...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-04-01
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| Series: | Stem Cell Research & Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13287-022-02822-2 |
| _version_ | 1811290492943466496 |
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| author | Meirong Li Yufeng Jiang Qian Hou Yali Zhao Lingzhi Zhong Xiaobing Fu |
| author_facet | Meirong Li Yufeng Jiang Qian Hou Yali Zhao Lingzhi Zhong Xiaobing Fu |
| author_sort | Meirong Li |
| collection | DOAJ |
| description | Abstract Mesenchymal stem cell (MSC)-based therapy has been considered as a promising approach targeting a variety of intractable diseases due to remarkable multiple effect of MSCs, such as multilineage differentiation, immunomodulatory property, and pro-regenerative capacity. However, poor engraftment, low survival rate of transplanted MSC, and impaired donor-MSC potency under host age/disease result in unsatisfactory therapeutic outcomes. Enhancement strategies, including genetic manipulation, pre-activation, and modification of culture method, have been investigated to generate highly functional MSC, and approaches for MSC pre-activation are highlighted. In this review, we summarized the current approaches of MSC pre-activation and further classified, analysed the scientific principles and main characteristics of these manipulations, and described the pros and cons of individual pre-activation strategies. We also discuss the specialized tactics to solve the challenges in this promising field so that it improves MSC therapeutic functions to serve patients better. |
| first_indexed | 2024-04-13T04:13:39Z |
| format | Article |
| id | doaj.art-c89b0ab9ca0f45c49ba72bc41274b8cd |
| institution | Directory Open Access Journal |
| issn | 1757-6512 |
| language | English |
| last_indexed | 2024-04-13T04:13:39Z |
| publishDate | 2022-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Stem Cell Research & Therapy |
| spelling | doaj.art-c89b0ab9ca0f45c49ba72bc41274b8cd2022-12-22T03:03:03ZengBMCStem Cell Research & Therapy1757-65122022-04-0113112110.1186/s13287-022-02822-2Potential pre-activation strategies for improving therapeutic efficacy of mesenchymal stem cells: current status and future prospectsMeirong Li0Yufeng Jiang1Qian Hou2Yali Zhao3Lingzhi Zhong4Xiaobing Fu5Research Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Division and 4th Medical Center, PLA General Hospital and PLA Medical CollegeWound Repairing Department, PLA Strategic Support Force Characteristic Medical CenterResearch Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Division and 4th Medical Center, PLA General Hospital and PLA Medical CollegeCentral Laboratory, Trauma Treatment Center, Chinese PLA General Hospital, Hainan HospitalResearch Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Division and 4th Medical Center, PLA General Hospital and PLA Medical CollegeResearch Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Division and 4th Medical Center, PLA General Hospital and PLA Medical CollegeAbstract Mesenchymal stem cell (MSC)-based therapy has been considered as a promising approach targeting a variety of intractable diseases due to remarkable multiple effect of MSCs, such as multilineage differentiation, immunomodulatory property, and pro-regenerative capacity. However, poor engraftment, low survival rate of transplanted MSC, and impaired donor-MSC potency under host age/disease result in unsatisfactory therapeutic outcomes. Enhancement strategies, including genetic manipulation, pre-activation, and modification of culture method, have been investigated to generate highly functional MSC, and approaches for MSC pre-activation are highlighted. In this review, we summarized the current approaches of MSC pre-activation and further classified, analysed the scientific principles and main characteristics of these manipulations, and described the pros and cons of individual pre-activation strategies. We also discuss the specialized tactics to solve the challenges in this promising field so that it improves MSC therapeutic functions to serve patients better.https://doi.org/10.1186/s13287-022-02822-2Mesenchymal stem cellPre-activationTherapeutic potentialIndividualized MSCs therapy |
| spellingShingle | Meirong Li Yufeng Jiang Qian Hou Yali Zhao Lingzhi Zhong Xiaobing Fu Potential pre-activation strategies for improving therapeutic efficacy of mesenchymal stem cells: current status and future prospects Stem Cell Research & Therapy Mesenchymal stem cell Pre-activation Therapeutic potential Individualized MSCs therapy |
| title | Potential pre-activation strategies for improving therapeutic efficacy of mesenchymal stem cells: current status and future prospects |
| title_full | Potential pre-activation strategies for improving therapeutic efficacy of mesenchymal stem cells: current status and future prospects |
| title_fullStr | Potential pre-activation strategies for improving therapeutic efficacy of mesenchymal stem cells: current status and future prospects |
| title_full_unstemmed | Potential pre-activation strategies for improving therapeutic efficacy of mesenchymal stem cells: current status and future prospects |
| title_short | Potential pre-activation strategies for improving therapeutic efficacy of mesenchymal stem cells: current status and future prospects |
| title_sort | potential pre activation strategies for improving therapeutic efficacy of mesenchymal stem cells current status and future prospects |
| topic | Mesenchymal stem cell Pre-activation Therapeutic potential Individualized MSCs therapy |
| url | https://doi.org/10.1186/s13287-022-02822-2 |
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