Does platelet-rich plasma enhance fusion in transforaminal lumbar interbody fusion? A prospective clinico-radiological comparative study
Background: Several animal studies have shown that platelet-rich plasma (PRP) is effective in enhancing bone fusion. However, the role and efficacy of PRP in spinal fusion surgery remain uncertain. The objective was to evaluate the efficacy of PRP in bone fusion and to compare the clinical and radio...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-01-01
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| Series: | Indian Spine Journal |
| Subjects: | |
| Online Access: | http://www.isjonline.com/article.asp?issn=2589-5079;year=2024;volume=7;issue=1;spage=80;epage=86;aulast=Sudhir |
| _version_ | 1827309498101923840 |
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| author | G Sudhir S Vignesh Jayabalan Gokul Prasath Raghav Ravi Veeraraghavan Karthik Kailash |
| author_facet | G Sudhir S Vignesh Jayabalan Gokul Prasath Raghav Ravi Veeraraghavan Karthik Kailash |
| author_sort | G Sudhir |
| collection | DOAJ |
| description | Background: Several animal studies have shown that platelet-rich plasma (PRP) is effective in enhancing bone fusion. However, the role and efficacy of PRP in spinal fusion surgery remain uncertain. The objective was to evaluate the efficacy of PRP in bone fusion and to compare the clinical and radiological outcomes of transforaminal lumbar interbody fusion (TLIF) with and without PRP. Materials and Methods: This prospective study was done on 50 patients who underwent TLIF surgery for various spinal pathologies. Patients were divided into the control group (underwent TLIF with interbody cage and local bone grafts alone) and the study group (underwent TLIF with interbody cage, local bone grafts, and PRP). Functional outcome was evaluated using visual analog score (VAS) and Oswestry disability index (ODI). Radiological outcome was assessed by Bridwell’s grading system for fusion on computed tomography scan at the end of 2 years. Results: The average bone fusion rate was significantly higher in the PRP group compared to the control group; however, the average duration of fusion was not statistically significant. There was no difference in VAS and ODI at 1 and 2 years. There was also no significant difference in lower back pain, leg pain, and numbness in both groups at the end of 1 year. Conclusion: Although there is no statistically significant difference in functional outcome between both groups, local application of PRP along with autologous bone grafts increases bone fusion rates with good clinical and radiological outcomes. |
| first_indexed | 2024-04-24T19:42:23Z |
| format | Article |
| id | doaj.art-c89b4284c4c74379af31d515ba24adee |
| institution | Directory Open Access Journal |
| issn | 2589-5079 2589-5087 |
| language | English |
| last_indexed | 2024-04-24T19:42:23Z |
| publishDate | 2024-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Spine Journal |
| spelling | doaj.art-c89b4284c4c74379af31d515ba24adee2024-03-25T10:58:51ZengWolters Kluwer Medknow PublicationsIndian Spine Journal2589-50792589-50872024-01-0171808610.4103/isj.isj_36_23Does platelet-rich plasma enhance fusion in transforaminal lumbar interbody fusion? A prospective clinico-radiological comparative studyG SudhirS Vignesh JayabalanGokul PrasathRaghav Ravi VeeraraghavanKarthik KailashBackground: Several animal studies have shown that platelet-rich plasma (PRP) is effective in enhancing bone fusion. However, the role and efficacy of PRP in spinal fusion surgery remain uncertain. The objective was to evaluate the efficacy of PRP in bone fusion and to compare the clinical and radiological outcomes of transforaminal lumbar interbody fusion (TLIF) with and without PRP. Materials and Methods: This prospective study was done on 50 patients who underwent TLIF surgery for various spinal pathologies. Patients were divided into the control group (underwent TLIF with interbody cage and local bone grafts alone) and the study group (underwent TLIF with interbody cage, local bone grafts, and PRP). Functional outcome was evaluated using visual analog score (VAS) and Oswestry disability index (ODI). Radiological outcome was assessed by Bridwell’s grading system for fusion on computed tomography scan at the end of 2 years. Results: The average bone fusion rate was significantly higher in the PRP group compared to the control group; however, the average duration of fusion was not statistically significant. There was no difference in VAS and ODI at 1 and 2 years. There was also no significant difference in lower back pain, leg pain, and numbness in both groups at the end of 1 year. Conclusion: Although there is no statistically significant difference in functional outcome between both groups, local application of PRP along with autologous bone grafts increases bone fusion rates with good clinical and radiological outcomes.http://www.isjonline.com/article.asp?issn=2589-5079;year=2024;volume=7;issue=1;spage=80;epage=86;aulast=Sudhirlumbar fusionplatelet-rich plasmatransforaminal lumbar interbody fusion |
| spellingShingle | G Sudhir S Vignesh Jayabalan Gokul Prasath Raghav Ravi Veeraraghavan Karthik Kailash Does platelet-rich plasma enhance fusion in transforaminal lumbar interbody fusion? A prospective clinico-radiological comparative study Indian Spine Journal lumbar fusion platelet-rich plasma transforaminal lumbar interbody fusion |
| title | Does platelet-rich plasma enhance fusion in transforaminal lumbar interbody fusion? A prospective clinico-radiological comparative study |
| title_full | Does platelet-rich plasma enhance fusion in transforaminal lumbar interbody fusion? A prospective clinico-radiological comparative study |
| title_fullStr | Does platelet-rich plasma enhance fusion in transforaminal lumbar interbody fusion? A prospective clinico-radiological comparative study |
| title_full_unstemmed | Does platelet-rich plasma enhance fusion in transforaminal lumbar interbody fusion? A prospective clinico-radiological comparative study |
| title_short | Does platelet-rich plasma enhance fusion in transforaminal lumbar interbody fusion? A prospective clinico-radiological comparative study |
| title_sort | does platelet rich plasma enhance fusion in transforaminal lumbar interbody fusion a prospective clinico radiological comparative study |
| topic | lumbar fusion platelet-rich plasma transforaminal lumbar interbody fusion |
| url | http://www.isjonline.com/article.asp?issn=2589-5079;year=2024;volume=7;issue=1;spage=80;epage=86;aulast=Sudhir |
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