Accelerated Maturation of Human Stem Cell-Derived Pancreatic Progenitor Cells into Insulin-Secreting Cells in Immunodeficient Rats Relative to Mice

Accelerated Maturation of Human Stem Cell-Derived Pancreatic Progenitor Cells into Insulin-Secreting Cells in Immunodeficient Rats Relative to Mice

Pluripotent human embryonic stem cells (hESCs) are a potential source of transplantable cells for treating patients with diabetes. To investigate the impact of the host recipient on hESC-derived pancreatic progenitor cell maturation, cells were transplanted into immunodeficient SCID-beige mice or nu...

Full description

Bibliographic Details
Main Authors:	Jennifer E. Bruin, Ali Asadi, Jessica K. Fox, Suheda Erener, Alireza Rezania, Timothy J. Kieffer
Format:	Article
Language:	English
Published:	Elsevier 2015-12-01
Series:	Stem Cell Reports
Online Access:	http://www.sciencedirect.com/science/article/pii/S2213671115003100

Similar Items

Treating Diet-Induced Diabetes and Obesity with Human Embryonic Stem Cell-Derived Pancreatic Progenitor Cells and Antidiabetic Drugs
by: Jennifer E. Bruin, et al.
Published: (2015-04-01)

Insulin secretion hot spots in pancreatic β cells as secreting adhesions
by: Margret A. Fye, et al.
Published: (2023-05-01)

Metabolic switching, growth kinetics and cell yields in the scalable manufacture of stem cell-derived insulin-producing cells
by: Diepiriye G. Iworima, et al.
Published: (2024-01-01)

Expansion and conversion of human pancreatic ductal cells into insulin-secreting endocrine cells
by: Jonghyeob Lee, et al.
Published: (2013-11-01)

Oscillations, intercellular coupling, and insulin secretion in pancreatic beta cells.
by: MacDonald, P, et al.
Published: (2006)

Insulin secretion: Function and therapy of pancreatic beta-cells in diabetes
by: Rorsman, P
Published: (2005)

Oscillations, intercellular coupling, and insulin secretion in pancreatic beta cells
by: Macdonald, P, et al.
Published: (2006)

MRI tracking of autologous pancreatic progenitor-derived insulin-producing cells in monkeys
by: Chunlin Zou, et al.
Published: (2017-05-01)

Diabetes, infection risk and COVID-19
by: Suheda Erener
Published: (2020-09-01)

Induction of Pancreatic Stem/Progenitor Cells into Insulin-Producing Cells by Adenoviral-Mediated Gene Transfer Technology
by: Hirofumi Noguchi M.D., Ph.D., et al.
Published: (2006-11-01)

Pancreatic β-cell electrical activity and insulin secretion: of mice and men
by: Rorsman, P, et al.
Published: (2017)

Platelet‐derived lipids promote insulin secretion of pancreatic β cells
by: Till Karwen, et al.
Published: (2023-09-01)

Novel metabolic role for BDNF in pancreatic β-cell insulin secretion
by: Gianluca Fulgenzi, et al.
Published: (2020-04-01)

Human Pluripotent Stem Cells: A Unique Tool for Toxicity Testing in Pancreatic Progenitor and Endocrine Cells
by: Erin M. MacFarlane, et al.
Published: (2021-01-01)

PVHL is a regulator of glucose metabolism and insulin secretion in pancreatic beta cells.
by: Zehetner, J, et al.
Published: (2008)

Roles of mTOR in the Regulation of Pancreatic β-Cell Mass and Insulin Secretion
by: Shun-ichiro Asahara, et al.
Published: (2022-04-01)

Loss of ZNF148 enhances insulin secretion in human pancreatic β cells
by: Eleonora de Klerk, et al.
Published: (2023-06-01)

A pathway model of glucose-stimulated insulin secretion in the pancreatic β-cell
by: M. Deepa Maheshvare, et al.
Published: (2023-08-01)

ATP is an essential autocrine factor for pancreatic β‐cell signaling and insulin secretion
by: Sebastian Hauke, et al.
Published: (2022-01-01)

Characterization of Human Pancreatic Progenitor Cells
by: Hirofumi Noguchi M.D., Ph.D., et al.
Published: (2010-06-01)

Induced maturation of hepatic progenitor cells in vitro
by: Y. Bi, et al.
Published: (2013-08-01)

Exosomes secreted by endothelial progenitor cells accelerate bone regeneration during distraction osteogenesis by stimulating angiogenesis
by: Yachao Jia, et al.
Published: (2019-01-01)

Fast insulin secretion reflects exocytosis of docked granules in mouse pancreatic B-cells.
by: Olofsson, C, et al.
Published: (2002)

Ca2+ transport in pancreatic beta-cells during glucose stimulation of insulin secretion.
by: Hellman, B, et al.
Published: (1980)

Lipid-Induced Adaptations of the Pancreatic Beta-Cell to Glucotoxic Conditions Sustain Insulin Secretion
by: Lucie Oberhauser, et al.
Published: (2021-12-01)

Cholesterol Redistribution in Pancreatic β-Cells: A Flexible Path to Regulate Insulin Secretion
by: Alessandra Galli, et al.
Published: (2023-01-01)

In Vivo ZIMIR Imaging of Mouse Pancreatic Islet Cells Shows Oscillatory Insulin Secretion
by: Shiuhwei Chen, et al.
Published: (2021-03-01)

Intracellular serotonin modulates insulin secretion from pancreatic beta-cells by protein serotonylation.
by: Nils Paulmann, et al.
Published: (2009-10-01)

Role of the active zone protein, ELKS, in insulin secretion from pancreatic β-cells
by: Mica Ohara-Imaizumi, et al.
Published: (2019-09-01)

Calcium Channels in Postnatal Development of Rat Pancreatic Beta Cells and Their Role in Insulin Secretion
by: Neivys García-Delgado, et al.
Published: (2018-03-01)

Cholesterol Sulfate Exerts Protective Effect on Pancreatic β-Cells by Regulating β-Cell Mass and Insulin Secretion
by: Xueping Zhang, et al.
Published: (2022-03-01)

Knockdown of ATP citrate lyase in pancreatic beta cells does not inhibit insulin secretion or glucose flux and implicates the acetoacetate pathway in insulin secretion
by: Mahmoud El Azzouny, et al.
Published: (2016-10-01)

Stathmin-2 Mediates Glucagon Secretion From Pancreatic α-Cells
by: Farzad Asadi, et al.
Published: (2020-02-01)

CXCL12 secreted by pancreatic stellate cells accelerates gemcitabine resistance of pancreatic cancer by enhancing glycolytic reprogramming
by: Xiangyu Lu, et al.
Published: (2022-07-01)

Deletion of pancreas-specific miR-216a reduces beta-cell mass and inhibits pancreatic cancer progression in mice
by: Suheda Erener, et al.
Published: (2021-11-01)

The Cell Physiology of Biphasic Insulin Secretion.
by: Rorsman, P, et al.
Published: (2000)

Protocol development to further differentiate and transition stem cell-derived pancreatic progenitors from a monolayer into endocrine cells in suspension culture
by: Mitchell J. S. Braam, et al.
Published: (2023-06-01)

Process parameter development for the scaled generation of stem cell‐derived pancreatic endocrine cells
by: Diepiriye G. Iworima, et al.
Published: (2021-11-01)

Fast exocytosis with few Ca(2+) channels in insulin-secreting mouse pancreatic B cells.
by: Barg, S, et al.
Published: (2001)

LDHB contributes to the regulation of lactate levels and basal insulin secretion in human pancreatic β cells
by: Federica Cuozzo, et al.
Published: (2024-04-01)