Fully implantable and battery-free wireless optoelectronic system for modulable cancer therapy and real-time monitoring

Abstract Photodynamic therapy (PDT) is attracting attention as a next-generation cancer treatment that can selectively destroy malignant tissues, exhibit fewer side effects, and lack pain during treatments. Implantable PDT systems have recently been developed to resolve the issues of bulky and expen...

Full description

Bibliographic Details
Main Authors: Kiho Kim, In Sik Min, Tae Hee Kim, Do Hyeon Kim, Seungwon Hwang, Kyowon Kang, Kyubeen Kim, Sangun Park, Jongmin Lee, Young Uk Cho, Jung Woo Lee, Woon-Hong Yeo, Young Min Song, Youngmee Jung, Ki Jun Yu
Format: Article
Language:English
Published: Nature Portfolio 2023-08-01
Series:npj Flexible Electronics
Online Access:https://doi.org/10.1038/s41528-023-00276-x
_version_ 1797555764289601536
author Kiho Kim
In Sik Min
Tae Hee Kim
Do Hyeon Kim
Seungwon Hwang
Kyowon Kang
Kyubeen Kim
Sangun Park
Jongmin Lee
Young Uk Cho
Jung Woo Lee
Woon-Hong Yeo
Young Min Song
Youngmee Jung
Ki Jun Yu
author_facet Kiho Kim
In Sik Min
Tae Hee Kim
Do Hyeon Kim
Seungwon Hwang
Kyowon Kang
Kyubeen Kim
Sangun Park
Jongmin Lee
Young Uk Cho
Jung Woo Lee
Woon-Hong Yeo
Young Min Song
Youngmee Jung
Ki Jun Yu
author_sort Kiho Kim
collection DOAJ
description Abstract Photodynamic therapy (PDT) is attracting attention as a next-generation cancer treatment that can selectively destroy malignant tissues, exhibit fewer side effects, and lack pain during treatments. Implantable PDT systems have recently been developed to resolve the issues of bulky and expensive conventional PDT systems and to implement continuous and repetitive treatment. Existing implantable PDT systems, however, are not able to perform multiple functions simultaneously, such as modulating light intensity, measuring, and transmitting tumor-related data, resulting in the complexity of cancer treatment. Here, we introduce a flexible and fully implantable wireless optoelectronic system capable of continuous and effective cancer treatment by fusing PDT and hyperthermia and enabling tumor size monitoring in real-time. This system exploits micro inorganic light-emitting diodes (μ-LED) that emit light with a wavelength of 624 nm, designed not to affect surrounding normal tissues by utilizing a fully programmable light intensity of μ-LED and precisely monitoring the tumor size by Si phototransistor during a long-term implantation (2–3 weeks). The superiority of simultaneous cancer treatment and tumor size monitoring capabilities of our system operated by wireless power and data transmissions with a cell phone was confirmed through in vitro experiments, ray-tracing simulation results, and a tumor xenograft mouse model in vivo. This all-in-one single system for cancer treatment offers opportunities to not only enable effective treatment of tumors located deep in the tissue but also enable precise and continuous monitoring of tumor size in real-time.
first_indexed 2024-03-10T16:52:14Z
format Article
id doaj.art-c89cb367344740a7b23737735c334d01
institution Directory Open Access Journal
issn 2397-4621
language English
last_indexed 2024-03-10T16:52:14Z
publishDate 2023-08-01
publisher Nature Portfolio
record_format Article
series npj Flexible Electronics
spelling doaj.art-c89cb367344740a7b23737735c334d012023-11-20T11:16:22ZengNature Portfolionpj Flexible Electronics2397-46212023-08-017111210.1038/s41528-023-00276-xFully implantable and battery-free wireless optoelectronic system for modulable cancer therapy and real-time monitoringKiho Kim0In Sik Min1Tae Hee Kim2Do Hyeon Kim3Seungwon Hwang4Kyowon Kang5Kyubeen Kim6Sangun Park7Jongmin Lee8Young Uk Cho9Jung Woo Lee10Woon-Hong Yeo11Young Min Song12Youngmee Jung13Ki Jun Yu14Functional Bio-integrated Electronics and Energy Management Lab, School of Electrical and Electronic Engineering, Yonsei UniversityFunctional Bio-integrated Electronics and Energy Management Lab, School of Electrical and Electronic Engineering, Yonsei UniversityCenter for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology (KIST)School of Electrical Engineering and Computer Science (EECS), Gwangju Institute of Science and Technology (GIST)PA1, Foundry Business, Samsung ElectronicsFunctional Bio-integrated Electronics and Energy Management Lab, School of Electrical and Electronic Engineering, Yonsei UniversityFunctional Bio-integrated Electronics and Energy Management Lab, School of Electrical and Electronic Engineering, Yonsei UniversityCenter for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology (KIST)KU-KIST Graduate School of Converging Science and Technology, Korea UniversityFunctional Bio-integrated Electronics and Energy Management Lab, School of Electrical and Electronic Engineering, Yonsei UniversitySchool of Materials Science and Engineering, Energy Materials for Soft Electronics Laboratory, Pusan National UniversityIEN Center for Human-Centric Interfaces and Engineering and George W. Woodruff School of Mechanical Engineering, Georgia Institute of TechnologySchool of Electrical Engineering and Computer Science (EECS), Gwangju Institute of Science and Technology (GIST)Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology (KIST)Functional Bio-integrated Electronics and Energy Management Lab, School of Electrical and Electronic Engineering, Yonsei UniversityAbstract Photodynamic therapy (PDT) is attracting attention as a next-generation cancer treatment that can selectively destroy malignant tissues, exhibit fewer side effects, and lack pain during treatments. Implantable PDT systems have recently been developed to resolve the issues of bulky and expensive conventional PDT systems and to implement continuous and repetitive treatment. Existing implantable PDT systems, however, are not able to perform multiple functions simultaneously, such as modulating light intensity, measuring, and transmitting tumor-related data, resulting in the complexity of cancer treatment. Here, we introduce a flexible and fully implantable wireless optoelectronic system capable of continuous and effective cancer treatment by fusing PDT and hyperthermia and enabling tumor size monitoring in real-time. This system exploits micro inorganic light-emitting diodes (μ-LED) that emit light with a wavelength of 624 nm, designed not to affect surrounding normal tissues by utilizing a fully programmable light intensity of μ-LED and precisely monitoring the tumor size by Si phototransistor during a long-term implantation (2–3 weeks). The superiority of simultaneous cancer treatment and tumor size monitoring capabilities of our system operated by wireless power and data transmissions with a cell phone was confirmed through in vitro experiments, ray-tracing simulation results, and a tumor xenograft mouse model in vivo. This all-in-one single system for cancer treatment offers opportunities to not only enable effective treatment of tumors located deep in the tissue but also enable precise and continuous monitoring of tumor size in real-time.https://doi.org/10.1038/s41528-023-00276-x
spellingShingle Kiho Kim
In Sik Min
Tae Hee Kim
Do Hyeon Kim
Seungwon Hwang
Kyowon Kang
Kyubeen Kim
Sangun Park
Jongmin Lee
Young Uk Cho
Jung Woo Lee
Woon-Hong Yeo
Young Min Song
Youngmee Jung
Ki Jun Yu
Fully implantable and battery-free wireless optoelectronic system for modulable cancer therapy and real-time monitoring
npj Flexible Electronics
title Fully implantable and battery-free wireless optoelectronic system for modulable cancer therapy and real-time monitoring
title_full Fully implantable and battery-free wireless optoelectronic system for modulable cancer therapy and real-time monitoring
title_fullStr Fully implantable and battery-free wireless optoelectronic system for modulable cancer therapy and real-time monitoring
title_full_unstemmed Fully implantable and battery-free wireless optoelectronic system for modulable cancer therapy and real-time monitoring
title_short Fully implantable and battery-free wireless optoelectronic system for modulable cancer therapy and real-time monitoring
title_sort fully implantable and battery free wireless optoelectronic system for modulable cancer therapy and real time monitoring
url https://doi.org/10.1038/s41528-023-00276-x
work_keys_str_mv AT kihokim fullyimplantableandbatteryfreewirelessoptoelectronicsystemformodulablecancertherapyandrealtimemonitoring
AT insikmin fullyimplantableandbatteryfreewirelessoptoelectronicsystemformodulablecancertherapyandrealtimemonitoring
AT taeheekim fullyimplantableandbatteryfreewirelessoptoelectronicsystemformodulablecancertherapyandrealtimemonitoring
AT dohyeonkim fullyimplantableandbatteryfreewirelessoptoelectronicsystemformodulablecancertherapyandrealtimemonitoring
AT seungwonhwang fullyimplantableandbatteryfreewirelessoptoelectronicsystemformodulablecancertherapyandrealtimemonitoring
AT kyowonkang fullyimplantableandbatteryfreewirelessoptoelectronicsystemformodulablecancertherapyandrealtimemonitoring
AT kyubeenkim fullyimplantableandbatteryfreewirelessoptoelectronicsystemformodulablecancertherapyandrealtimemonitoring
AT sangunpark fullyimplantableandbatteryfreewirelessoptoelectronicsystemformodulablecancertherapyandrealtimemonitoring
AT jongminlee fullyimplantableandbatteryfreewirelessoptoelectronicsystemformodulablecancertherapyandrealtimemonitoring
AT youngukcho fullyimplantableandbatteryfreewirelessoptoelectronicsystemformodulablecancertherapyandrealtimemonitoring
AT jungwoolee fullyimplantableandbatteryfreewirelessoptoelectronicsystemformodulablecancertherapyandrealtimemonitoring
AT woonhongyeo fullyimplantableandbatteryfreewirelessoptoelectronicsystemformodulablecancertherapyandrealtimemonitoring
AT youngminsong fullyimplantableandbatteryfreewirelessoptoelectronicsystemformodulablecancertherapyandrealtimemonitoring
AT youngmeejung fullyimplantableandbatteryfreewirelessoptoelectronicsystemformodulablecancertherapyandrealtimemonitoring
AT kijunyu fullyimplantableandbatteryfreewirelessoptoelectronicsystemformodulablecancertherapyandrealtimemonitoring