EFFECT OF NOVEL OINTMENT COMPOSITION AG/TAGA: CHITOSAN-GEL ON HEALING OF EXPERIMENTAL WOUNDS WITH DIFFERENT ORIGINS
The purpose of the study – evaluation of the regenerating activity of two-component paste, consisting of silver containing finely particulate sorbent: chitosan gel.Material and methodologies. For the study we used novel excipient, consisting of two components: silver containing finely particulate so...
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| Format: | Article |
| Language: | English |
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Siberian State Medical University (Tomsk)
2016-03-01
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| Series: | Бюллетень сибирской медицины |
| Subjects: | |
| Online Access: | https://bulletin.ssmu.ru/jour/article/view/486 |
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| author | T. V. Popova T. G. Tolstikova A. Yu. Letyagin N. A. Zhukova N. P. Bgatova L. N. Rachkovskaya A. A. Kotlyrova V. A. Burmistrov |
| author_facet | T. V. Popova T. G. Tolstikova A. Yu. Letyagin N. A. Zhukova N. P. Bgatova L. N. Rachkovskaya A. A. Kotlyrova V. A. Burmistrov |
| author_sort | T. V. Popova |
| collection | DOAJ |
| description | The purpose of the study – evaluation of the regenerating activity of two-component paste, consisting of silver containing finely particulate sorbent: chitosan gel.Material and methodologies. For the study we used novel excipient, consisting of two components: silver containing finely particulate sorbent: chitosan gel in ratio one-to-one. Novel sorbent agent, taken for study, consists of thermally activated silica containing aluminum hydroxide in the form of its modification silver. Experiment was conducted on 48 Wistar models in case of scalp (degloving) wound (abscission of skin area 30–40 mm2 in size on depilated side surface) and chemical burn (applying 1–2 drops of 70% sulfuric acid on the depilated surface side. Regenerating activity was evaluated based on morphometry area of the wound surface, fixing the rate of scarring. Evaluation was made histologically on 4th - micrometers paraffin sections, stained with hematoxylin and eosin, and semithin sections, stained with toluidine blue.The results of study. Composition (paste) developed from silver containing finely particulate sorbent: chitosan gel sped up (for 3 days) the process of reparative regeneration of tissue on the model of chemical burns, helped to structuring formations in skin by the type of granuloma, at the same time there were no signs of perifocal inflammation. In case of scalp wound ointment composition wasn’t conducive to raising the rate of regeneration.Conclusion. Developed excipient (paste) is effective at the first phase of wound healing process, which was showed on scalped and burn wounds, as hydrophilic base had a large sorption capacity. Traumatic effect of dry sorbent powder (powder) on the surface of the wound was offset by connecting the sorption component and a hydrophilic ointment base. |
| first_indexed | 2024-04-10T01:07:53Z |
| format | Article |
| id | doaj.art-c89d2ef86caa431f9c40a9b7c34522da |
| institution | Directory Open Access Journal |
| issn | 1682-0363 1819-3684 |
| language | English |
| last_indexed | 2024-04-10T01:07:53Z |
| publishDate | 2016-03-01 |
| publisher | Siberian State Medical University (Tomsk) |
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| series | Бюллетень сибирской медицины |
| spelling | doaj.art-c89d2ef86caa431f9c40a9b7c34522da2023-03-13T09:58:22ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842016-03-01151475410.20538/1682-0363-2016-1-47-54459EFFECT OF NOVEL OINTMENT COMPOSITION AG/TAGA: CHITOSAN-GEL ON HEALING OF EXPERIMENTAL WOUNDS WITH DIFFERENT ORIGINST. V. Popova0T. G. Tolstikova1A. Yu. Letyagin2N. A. Zhukova3N. P. Bgatova4L. N. Rachkovskaya5A. A. Kotlyrova6V. A. Burmistrov7Научно-исследовательский институт клинической и экспериментальной лимфологии (НИИКЭЛ), г. Новосибирск, 630117, ул. Тимакова, 2Новосибирский институт органической химии им. Н.Н. Ворожцова (НИОХ) СО РАН, г. Новосибирск 630090, пр. Академика Лаврентьева, д. 9Научно-исследовательский институт клинической и экспериментальной лимфологии (НИИКЭЛ), г. Новосибирск, 630117, ул. Тимакова, 2Новосибирский институт органической химии им. Н.Н. Ворожцова (НИОХ) СО РАН, г. Новосибирск 630090, пр. Академика Лаврентьева, д. 9Научно-исследовательский институт клинической и экспериментальной лимфологии (НИИКЭЛ), г. Новосибирск, 630117, ул. Тимакова, 2Научно-исследовательский институт клинической и экспериментальной лимфологии (НИИКЭЛ), г. Новосибирск, 630117, ул. Тимакова, 2Научно-исследовательский институт клинической и экспериментальной лимфологии (НИИКЭЛ), г. Новосибирск, 630117, ул. Тимакова, 2Научно-исследовательский институт клинической и экспериментальной лимфологии (НИИКЭЛ), г. Новосибирск, 630117, ул. Тимакова, 2The purpose of the study – evaluation of the regenerating activity of two-component paste, consisting of silver containing finely particulate sorbent: chitosan gel.Material and methodologies. For the study we used novel excipient, consisting of two components: silver containing finely particulate sorbent: chitosan gel in ratio one-to-one. Novel sorbent agent, taken for study, consists of thermally activated silica containing aluminum hydroxide in the form of its modification silver. Experiment was conducted on 48 Wistar models in case of scalp (degloving) wound (abscission of skin area 30–40 mm2 in size on depilated side surface) and chemical burn (applying 1–2 drops of 70% sulfuric acid on the depilated surface side. Regenerating activity was evaluated based on morphometry area of the wound surface, fixing the rate of scarring. Evaluation was made histologically on 4th - micrometers paraffin sections, stained with hematoxylin and eosin, and semithin sections, stained with toluidine blue.The results of study. Composition (paste) developed from silver containing finely particulate sorbent: chitosan gel sped up (for 3 days) the process of reparative regeneration of tissue on the model of chemical burns, helped to structuring formations in skin by the type of granuloma, at the same time there were no signs of perifocal inflammation. In case of scalp wound ointment composition wasn’t conducive to raising the rate of regeneration.Conclusion. Developed excipient (paste) is effective at the first phase of wound healing process, which was showed on scalped and burn wounds, as hydrophilic base had a large sorption capacity. Traumatic effect of dry sorbent powder (powder) on the surface of the wound was offset by connecting the sorption component and a hydrophilic ointment base.https://bulletin.ssmu.ru/jour/article/view/486регенерацияраныхимический ожогсеребросодержащие сорбенты |
| spellingShingle | T. V. Popova T. G. Tolstikova A. Yu. Letyagin N. A. Zhukova N. P. Bgatova L. N. Rachkovskaya A. A. Kotlyrova V. A. Burmistrov EFFECT OF NOVEL OINTMENT COMPOSITION AG/TAGA: CHITOSAN-GEL ON HEALING OF EXPERIMENTAL WOUNDS WITH DIFFERENT ORIGINS Бюллетень сибирской медицины регенерация раны химический ожог серебросодержащие сорбенты |
| title | EFFECT OF NOVEL OINTMENT COMPOSITION AG/TAGA: CHITOSAN-GEL ON HEALING OF EXPERIMENTAL WOUNDS WITH DIFFERENT ORIGINS |
| title_full | EFFECT OF NOVEL OINTMENT COMPOSITION AG/TAGA: CHITOSAN-GEL ON HEALING OF EXPERIMENTAL WOUNDS WITH DIFFERENT ORIGINS |
| title_fullStr | EFFECT OF NOVEL OINTMENT COMPOSITION AG/TAGA: CHITOSAN-GEL ON HEALING OF EXPERIMENTAL WOUNDS WITH DIFFERENT ORIGINS |
| title_full_unstemmed | EFFECT OF NOVEL OINTMENT COMPOSITION AG/TAGA: CHITOSAN-GEL ON HEALING OF EXPERIMENTAL WOUNDS WITH DIFFERENT ORIGINS |
| title_short | EFFECT OF NOVEL OINTMENT COMPOSITION AG/TAGA: CHITOSAN-GEL ON HEALING OF EXPERIMENTAL WOUNDS WITH DIFFERENT ORIGINS |
| title_sort | effect of novel ointment composition ag taga chitosan gel on healing of experimental wounds with different origins |
| topic | регенерация раны химический ожог серебросодержащие сорбенты |
| url | https://bulletin.ssmu.ru/jour/article/view/486 |
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