Dysphagia in Perry Syndrome: Pharyngeal Pressure in Two Cases
Background: To investigate the impact of dysphagia in Perry syndrome (PS), an autosomal dominant parkinsonism caused by mutation of DCTN1, which is associated with hypoventilation, depression, and weight loss. Case Presentation: We used tongue pressure measurements and manofluorography to investigat...
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| Format: | Article |
| Language: | English |
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Karger Publishers
2017-06-01
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| Series: | Case Reports in Neurology |
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| Online Access: | http://prod.karger.com/Article/FullText/457900 |
| _version_ | 1818607938655223808 |
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| author | George Umemoto Yoshio Tsuboi Hirokazu Furuya Takayasu Mishima Shinsuke Fujioka Naoki Fujii Hajime Arahata Miwa Sugahara Mitsuaki Sakai |
| author_facet | George Umemoto Yoshio Tsuboi Hirokazu Furuya Takayasu Mishima Shinsuke Fujioka Naoki Fujii Hajime Arahata Miwa Sugahara Mitsuaki Sakai |
| author_sort | George Umemoto |
| collection | DOAJ |
| description | Background: To investigate the impact of dysphagia in Perry syndrome (PS), an autosomal dominant parkinsonism caused by mutation of DCTN1, which is associated with hypoventilation, depression, and weight loss. Case Presentation: We used tongue pressure measurements and manofluorography to investigate swallowing function in 2 patients with PS. Case 1, a 60-year-old male showing parkinsonism, and case 2, a 49-year-old male admitted with pneumonia, were diagnosed as having PS based on the DCTN1 gene analysis. Case 1 showed a pharyngeal retention of the bolus on videofluorography (VF) and a few swallows were required for its passage into the esophagus. However, tongue pressure and manometry were within the normal range. This patient could eat a normal diet under supervision. Case 2 required artificial ventilation and tube feeding on admission. The VF image showed a slow transfer of the bolus, delayed swallow reflex, and pharyngeal retention of the bolus that required several swallows for its passage into the esophagus. The tongue pressure was within the normal range, but manometry showed a significant decrease in pressure at the hypopharynx and upper esophageal sphincter. The oral intake of the patients was limited to 2 cups of jelly per day. Conclusions: The investigation of swallowing dysfunction of 2 cases of PS showed that maintaining pharyngeal pressure within the normal range was very important for oral feeding success and prognosis. |
| first_indexed | 2024-12-16T14:34:42Z |
| format | Article |
| id | doaj.art-c89d4104d4e44de08c5caab8474ffee3 |
| institution | Directory Open Access Journal |
| issn | 1662-680X |
| language | English |
| last_indexed | 2024-12-16T14:34:42Z |
| publishDate | 2017-06-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Neurology |
| spelling | doaj.art-c89d4104d4e44de08c5caab8474ffee32022-12-21T22:28:08ZengKarger PublishersCase Reports in Neurology1662-680X2017-06-019216116710.1159/000457900457900Dysphagia in Perry Syndrome: Pharyngeal Pressure in Two CasesGeorge UmemotoYoshio TsuboiHirokazu FuruyaTakayasu MishimaShinsuke FujiokaNaoki FujiiHajime ArahataMiwa SugaharaMitsuaki SakaiBackground: To investigate the impact of dysphagia in Perry syndrome (PS), an autosomal dominant parkinsonism caused by mutation of DCTN1, which is associated with hypoventilation, depression, and weight loss. Case Presentation: We used tongue pressure measurements and manofluorography to investigate swallowing function in 2 patients with PS. Case 1, a 60-year-old male showing parkinsonism, and case 2, a 49-year-old male admitted with pneumonia, were diagnosed as having PS based on the DCTN1 gene analysis. Case 1 showed a pharyngeal retention of the bolus on videofluorography (VF) and a few swallows were required for its passage into the esophagus. However, tongue pressure and manometry were within the normal range. This patient could eat a normal diet under supervision. Case 2 required artificial ventilation and tube feeding on admission. The VF image showed a slow transfer of the bolus, delayed swallow reflex, and pharyngeal retention of the bolus that required several swallows for its passage into the esophagus. The tongue pressure was within the normal range, but manometry showed a significant decrease in pressure at the hypopharynx and upper esophageal sphincter. The oral intake of the patients was limited to 2 cups of jelly per day. Conclusions: The investigation of swallowing dysfunction of 2 cases of PS showed that maintaining pharyngeal pressure within the normal range was very important for oral feeding success and prognosis.http://prod.karger.com/Article/FullText/457900Perry syndromeDysphagiaVideofluorographyManometryTongue pressure |
| spellingShingle | George Umemoto Yoshio Tsuboi Hirokazu Furuya Takayasu Mishima Shinsuke Fujioka Naoki Fujii Hajime Arahata Miwa Sugahara Mitsuaki Sakai Dysphagia in Perry Syndrome: Pharyngeal Pressure in Two Cases Case Reports in Neurology Perry syndrome Dysphagia Videofluorography Manometry Tongue pressure |
| title | Dysphagia in Perry Syndrome: Pharyngeal Pressure in Two Cases |
| title_full | Dysphagia in Perry Syndrome: Pharyngeal Pressure in Two Cases |
| title_fullStr | Dysphagia in Perry Syndrome: Pharyngeal Pressure in Two Cases |
| title_full_unstemmed | Dysphagia in Perry Syndrome: Pharyngeal Pressure in Two Cases |
| title_short | Dysphagia in Perry Syndrome: Pharyngeal Pressure in Two Cases |
| title_sort | dysphagia in perry syndrome pharyngeal pressure in two cases |
| topic | Perry syndrome Dysphagia Videofluorography Manometry Tongue pressure |
| url | http://prod.karger.com/Article/FullText/457900 |
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