Inflammatory Cytokines Associated with Obesity, Type-2 Diabetes, and Hypertension Exacerbate Breast Cancer Risk in Underserved African American and Latin American Women
<b>Background:</b> Comorbid chronic diseases, such as obesity, Type-2 Diabetes (T2D), and hypertension (HTN), are major public health issues and highly prevalent among underserved African Americans (AA) and Latin Americans (LA). Elevated inflammatory cytokines are underlying processes in...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-03-01
|
| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/13/6/1687 |
| _version_ | 1797240572811935744 |
|---|---|
| author | Yanyuan Wu Eduard Karapetyan Pranabananda Dutta Magda Shaheen Jaydutt V. Vadgama |
| author_facet | Yanyuan Wu Eduard Karapetyan Pranabananda Dutta Magda Shaheen Jaydutt V. Vadgama |
| author_sort | Yanyuan Wu |
| collection | DOAJ |
| description | <b>Background:</b> Comorbid chronic diseases, such as obesity, Type-2 Diabetes (T2D), and hypertension (HTN), are major public health issues and highly prevalent among underserved African Americans (AA) and Latin Americans (LA). Elevated inflammatory cytokines are underlying processes in comorbidities (obesity, T2D, and HTN) that could contribute to tumorigenesis and adverse cancer outcomes. <b>Methods:</b> A panel of 19 cytokines was measured by Luminex assay from 570 AA and LA women’s serum samples. The comorbidities and breast cancer information were extracted from our existing clinical database. Comorbidity-associated cytokines were identified by linear regression analysis, and the odds ratios of increasing cytokines for breast cancer were evaluated by Logistic regression. <b>Results:</b> Women with obesity, T2D, and HTN elevated specific groups of cytokines. EGF, MCP1, MDC, MIP-1b, and Groα were independent of T2D and HTN significantly associated with obesity. TGFβ1 and TGFβ2 were T2D-associated cytokines, and MIB-1b, TNFα, and VEGFα were HTN-associated cytokines. Among those comorbidity-associated cytokines, CXCL1, CCL4, CXCL10, TNFα, TGFβ1, and TGFβ2 were also significantly associated with breast cancer diagnosed at age < 50. Two or more comorbidities further increased the levels of Groα, MIP-1b, TNFα, and TGFβs. <b>Conclusions:</b> Comorbidity-associate cytokines could augment the risk of breast cancer for AA and LA women. |
| first_indexed | 2024-04-24T18:09:34Z |
| format | Article |
| id | doaj.art-c89d84877ad846e6a6abfe1a0aefa208 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-04-24T18:09:34Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-c89d84877ad846e6a6abfe1a0aefa2082024-03-27T13:48:02ZengMDPI AGJournal of Clinical Medicine2077-03832024-03-01136168710.3390/jcm13061687Inflammatory Cytokines Associated with Obesity, Type-2 Diabetes, and Hypertension Exacerbate Breast Cancer Risk in Underserved African American and Latin American WomenYanyuan Wu0Eduard Karapetyan1Pranabananda Dutta2Magda Shaheen3Jaydutt V. Vadgama4Division of Cancer Research and Training, Department of Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, CA 90059, USADivision of Cancer Research and Training, Department of Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, CA 90059, USADivision of Cancer Research and Training, Department of Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, CA 90059, USADivision of Cancer Research and Training, Department of Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, CA 90059, USADivision of Cancer Research and Training, Department of Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, CA 90059, USA<b>Background:</b> Comorbid chronic diseases, such as obesity, Type-2 Diabetes (T2D), and hypertension (HTN), are major public health issues and highly prevalent among underserved African Americans (AA) and Latin Americans (LA). Elevated inflammatory cytokines are underlying processes in comorbidities (obesity, T2D, and HTN) that could contribute to tumorigenesis and adverse cancer outcomes. <b>Methods:</b> A panel of 19 cytokines was measured by Luminex assay from 570 AA and LA women’s serum samples. The comorbidities and breast cancer information were extracted from our existing clinical database. Comorbidity-associated cytokines were identified by linear regression analysis, and the odds ratios of increasing cytokines for breast cancer were evaluated by Logistic regression. <b>Results:</b> Women with obesity, T2D, and HTN elevated specific groups of cytokines. EGF, MCP1, MDC, MIP-1b, and Groα were independent of T2D and HTN significantly associated with obesity. TGFβ1 and TGFβ2 were T2D-associated cytokines, and MIB-1b, TNFα, and VEGFα were HTN-associated cytokines. Among those comorbidity-associated cytokines, CXCL1, CCL4, CXCL10, TNFα, TGFβ1, and TGFβ2 were also significantly associated with breast cancer diagnosed at age < 50. Two or more comorbidities further increased the levels of Groα, MIP-1b, TNFα, and TGFβs. <b>Conclusions:</b> Comorbidity-associate cytokines could augment the risk of breast cancer for AA and LA women.https://www.mdpi.com/2077-0383/13/6/1687comorbiditybreast cancercytokinesAfrican AmericanLatin American |
| spellingShingle | Yanyuan Wu Eduard Karapetyan Pranabananda Dutta Magda Shaheen Jaydutt V. Vadgama Inflammatory Cytokines Associated with Obesity, Type-2 Diabetes, and Hypertension Exacerbate Breast Cancer Risk in Underserved African American and Latin American Women Journal of Clinical Medicine comorbidity breast cancer cytokines African American Latin American |
| title | Inflammatory Cytokines Associated with Obesity, Type-2 Diabetes, and Hypertension Exacerbate Breast Cancer Risk in Underserved African American and Latin American Women |
| title_full | Inflammatory Cytokines Associated with Obesity, Type-2 Diabetes, and Hypertension Exacerbate Breast Cancer Risk in Underserved African American and Latin American Women |
| title_fullStr | Inflammatory Cytokines Associated with Obesity, Type-2 Diabetes, and Hypertension Exacerbate Breast Cancer Risk in Underserved African American and Latin American Women |
| title_full_unstemmed | Inflammatory Cytokines Associated with Obesity, Type-2 Diabetes, and Hypertension Exacerbate Breast Cancer Risk in Underserved African American and Latin American Women |
| title_short | Inflammatory Cytokines Associated with Obesity, Type-2 Diabetes, and Hypertension Exacerbate Breast Cancer Risk in Underserved African American and Latin American Women |
| title_sort | inflammatory cytokines associated with obesity type 2 diabetes and hypertension exacerbate breast cancer risk in underserved african american and latin american women |
| topic | comorbidity breast cancer cytokines African American Latin American |
| url | https://www.mdpi.com/2077-0383/13/6/1687 |
| work_keys_str_mv | AT yanyuanwu inflammatorycytokinesassociatedwithobesitytype2diabetesandhypertensionexacerbatebreastcancerriskinunderservedafricanamericanandlatinamericanwomen AT eduardkarapetyan inflammatorycytokinesassociatedwithobesitytype2diabetesandhypertensionexacerbatebreastcancerriskinunderservedafricanamericanandlatinamericanwomen AT pranabanandadutta inflammatorycytokinesassociatedwithobesitytype2diabetesandhypertensionexacerbatebreastcancerriskinunderservedafricanamericanandlatinamericanwomen AT magdashaheen inflammatorycytokinesassociatedwithobesitytype2diabetesandhypertensionexacerbatebreastcancerriskinunderservedafricanamericanandlatinamericanwomen AT jayduttvvadgama inflammatorycytokinesassociatedwithobesitytype2diabetesandhypertensionexacerbatebreastcancerriskinunderservedafricanamericanandlatinamericanwomen |