The anti-sigma factor RsrA responds to oxidative stress by reburying its hydrophobic core
Counteracting oxidative stress is essential in all organisms. Here, the authors outline a mechanism used by actinomycete bacteria in which oxidation of zinc-binding RsrA blocks its interaction with σR by sequestering hydrophobic residues used to bind σRwithin its own core.
Bibliographic Details
| Main Authors: |
Karthik V. Rajasekar,
Konrad Zdanowski,
Jun Yan,
Jonathan T. S. Hopper,
Marie-Louise R. Francis,
Colin Seepersad,
Connor Sharp,
Ludovic Pecqueur,
Jörn M. Werner,
Carol V. Robinson,
Shabaz Mohammed,
Jennifer R. Potts,
Colin Kleanthous |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2016-07-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/ncomms12194
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