Systematic analysis of RNA-binding proteins identifies targetable therapeutic vulnerabilities in osteosarcoma

Systematic analysis of RNA-binding proteins identifies targetable therapeutic vulnerabilities in osteosarcoma

Abstract Osteosarcoma is the most common primary malignant bone tumor with a strong tendency to metastasize, limiting the prognosis of affected patients. Genomic, epigenomic and transcriptomic analyses have demonstrated the exquisite molecular complexity of this tumor, but have not sufficiently defi...

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Bibliographic Details
Main Authors: Yang Zhou, Partho Sarothi Ray, Jianguo Zhu, Frank Stein, Mandy Rettel, Thileepan Sekaran, Sudeep Sahadevan, Joel I. Perez-Perri, Eva K. Roth, Ola Myklebost, Leonardo A. Meza-Zepeda, Andreas von Deimling, Chuli Fu, Annika N. Brosig, Kjetil Boye, Michaela Nathrath, Claudia Blattmann, Burkhard Lehner, Matthias W. Hentze, Andreas E. Kulozik
Format: Article
Language:English
Published: Nature Portfolio 2024-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-47031-y

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