New insights in ferroptosis: Potential therapeutic targets for the treatment of ischemic stroke
Stroke is a common disease in clinical practice, which seriously endangers people’s physical and mental health. The neurovascular unit (NVU) plays a key role in the occurrence and development of ischemic stroke. Different from other classical types of cell death such as apoptosis, necrosis, autophag...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.1020918/full |
| _version_ | 1818469277456400384 |
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| author | Ziqing Wei Ziqing Wei Ziqing Wei Yi Xie Yi Xie Mingze Wei Huijuan Zhao Kaidi Ren Kaidi Ren Kaidi Ren Qi Feng Qi Feng Qi Feng Yuming Xu Yuming Xu |
| author_facet | Ziqing Wei Ziqing Wei Ziqing Wei Yi Xie Yi Xie Mingze Wei Huijuan Zhao Kaidi Ren Kaidi Ren Kaidi Ren Qi Feng Qi Feng Qi Feng Yuming Xu Yuming Xu |
| author_sort | Ziqing Wei |
| collection | DOAJ |
| description | Stroke is a common disease in clinical practice, which seriously endangers people’s physical and mental health. The neurovascular unit (NVU) plays a key role in the occurrence and development of ischemic stroke. Different from other classical types of cell death such as apoptosis, necrosis, autophagy, and pyroptosis, ferroptosis is an iron-dependent lipid peroxidation-driven new form of cell death. Interestingly, the function of NVU and stroke development can be regulated by activating or inhibiting ferroptosis. This review systematically describes the NVU in ischemic stroke, provides a comprehensive overview of the regulatory mechanisms and key regulators of ferroptosis, and uncovers the role of ferroptosis in the NVU and the progression of ischemic stroke. We further discuss the latest progress in the intervention of ferroptosis as a therapeutic target for ischemic stroke and summarize the research progress and regulatory mechanism of ferroptosis inhibitors on stroke. In conclusion, ferroptosis, as a new form of cell death, plays a key role in ischemic stroke and is expected to become a new therapeutic target for this disease. |
| first_indexed | 2024-04-13T21:21:50Z |
| format | Article |
| id | doaj.art-c8a3db74d9d6435f985008039505dac0 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-13T21:21:50Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-c8a3db74d9d6435f985008039505dac02022-12-22T02:29:28ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-11-011310.3389/fphar.2022.10209181020918New insights in ferroptosis: Potential therapeutic targets for the treatment of ischemic strokeZiqing Wei0Ziqing Wei1Ziqing Wei2Yi Xie3Yi Xie4Mingze Wei5Huijuan Zhao6Kaidi Ren7Kaidi Ren8Kaidi Ren9Qi Feng10Qi Feng11Qi Feng12Yuming Xu13Yuming Xu14Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaHenan Key Laboratory of Cerebrovascular Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaClinical Systems Biology Laboratories, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaHenan Key Laboratory of Cerebrovascular Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaThe Second Clinical Medical College, Harbin Medical University, Harbin, ChinaHenan International Joint Laboratory of Thrombosis and Hemostasis, Basic Medical College, Henan University of Science and Technology, Luoyang, ChinaDepartment of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaHenan Key Laboratory of Precision Clinical Pharmacy, Zhengzhou, ChinaHenan Engineering Research Center for Application & Translation of Precision Clinical Pharmacy, Zhengzhou University, Zhengzhou, ChinaResearch Institute of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China0Department of Integrated Traditional and Western Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China1Henan Province Research Center for Kidney Disease, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaHenan Key Laboratory of Cerebrovascular Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaStroke is a common disease in clinical practice, which seriously endangers people’s physical and mental health. The neurovascular unit (NVU) plays a key role in the occurrence and development of ischemic stroke. Different from other classical types of cell death such as apoptosis, necrosis, autophagy, and pyroptosis, ferroptosis is an iron-dependent lipid peroxidation-driven new form of cell death. Interestingly, the function of NVU and stroke development can be regulated by activating or inhibiting ferroptosis. This review systematically describes the NVU in ischemic stroke, provides a comprehensive overview of the regulatory mechanisms and key regulators of ferroptosis, and uncovers the role of ferroptosis in the NVU and the progression of ischemic stroke. We further discuss the latest progress in the intervention of ferroptosis as a therapeutic target for ischemic stroke and summarize the research progress and regulatory mechanism of ferroptosis inhibitors on stroke. In conclusion, ferroptosis, as a new form of cell death, plays a key role in ischemic stroke and is expected to become a new therapeutic target for this disease.https://www.frontiersin.org/articles/10.3389/fphar.2022.1020918/fullstrokeneurovascular unit (NVU)ferroptosisinhibitorstherapeutic target |
| spellingShingle | Ziqing Wei Ziqing Wei Ziqing Wei Yi Xie Yi Xie Mingze Wei Huijuan Zhao Kaidi Ren Kaidi Ren Kaidi Ren Qi Feng Qi Feng Qi Feng Yuming Xu Yuming Xu New insights in ferroptosis: Potential therapeutic targets for the treatment of ischemic stroke Frontiers in Pharmacology stroke neurovascular unit (NVU) ferroptosis inhibitors therapeutic target |
| title | New insights in ferroptosis: Potential therapeutic targets for the treatment of ischemic stroke |
| title_full | New insights in ferroptosis: Potential therapeutic targets for the treatment of ischemic stroke |
| title_fullStr | New insights in ferroptosis: Potential therapeutic targets for the treatment of ischemic stroke |
| title_full_unstemmed | New insights in ferroptosis: Potential therapeutic targets for the treatment of ischemic stroke |
| title_short | New insights in ferroptosis: Potential therapeutic targets for the treatment of ischemic stroke |
| title_sort | new insights in ferroptosis potential therapeutic targets for the treatment of ischemic stroke |
| topic | stroke neurovascular unit (NVU) ferroptosis inhibitors therapeutic target |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.1020918/full |
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